Conserved Protein Domain Family
APG6

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pfam04111: APG6 (this model, PSSM-Id:282029 is obsolete and has been replaced by 397986)
Autophagy protein Apg6
In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.
Statistics
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PSSM-Id: 282029
View PSSM: pfam04111
Aligned: 147 rows
Threshold Bit Score: 169.277
Threshold Setting Gi: 459656705
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6CLQ7        137 PVCQGCCDTLLEKLKEEYNQELKKRDTYHDFMKRIQEHknvngin-------------------------igdnralE-- 189  Kluyveromyces...
Q5CPI7        103 sLCVDCMNCSISQFSMALNKEISLLDKYKEISDSLISSecydedq--------------------------------med 150  Cryptosporidi...
A0DRK9         19 mYCEKCLQQQMKKEEEEVKQLENEINELQIQLKQVRDEmy---------------------------------------- 58   Paramecium te...
XP_002177919  101 hLCLECIQRVEQALLADTERLKYETKRYDEAVRDERDRqrslh-----------------------------qalnaV-- 149  Phaeodactylum...
XP_003291506  776 ilCGSCLSRFKTILDEFDQEESLESQMYKNFFLTKQKKqekdeneedeeln--------------------qdddtdeed 835  Dictyostelium...
EFA86429      525 tLCGPCISTLKEYLERMNQELQRDYTTYTQFIQDHNINikqdnnnndnnnnnsnntnnittfnsnntnkqsftpsihKsk 604  Polysphondyli...
XP_004027370   36 yYCFEC-KQKLEQGTKEIEQLEKQINEIQINLTEINS------------------------------------------- 71   Ichthyophthir...
XP_012655476   42 yLCEPCLKIQLKNEFQDIEIIGQEITETQKKLQLVDENmis--------------------------------------- 82   Tetrahymena t...
XP_002140137   94 sVCVECIDKLIMQFELNLNKTIDETKTLNLLIGNIDYSve---------------------------------------- 133  Cryptosporidi...
EKD01414      144 PLCMECTGLFQKELQRELEDLTRERDAYINFERTIRKRaegseg---------------------------------iig 190  Trichosporon ...
Q6CLQ7        190 ---E-----------LS---------------S----LK-----KEKEQLLRELQRLEDED----EKLQKETILL----- 222  Kluyveromyces...
Q5CPI7        151 sevNfeptskeyleiMN---------------IynefIKmeqynQEKTIINDENDNDEIDCtetdKDIKEGYGKC----- 210  Cryptosporidi...
A0DRK9         59 -kmEtnqi----ekkND---------------K----IE-----LDKKNLDKEIYQLEQDE----QQQKKELIKL----- 100  Paramecium te...
XP_002177919  150 ---Sfagl----gdnFQpefmsqsadadssspL----LQ-----RAEEAFRNEIEALQQCC----DQQEDEIGHLrslvk 209  Phaeodactylum...
XP_003291506  836 lknEllni----ekeIN---------------D----LE-----KEEKELIQEYLELENQN----QINLDIKIKL----- 878  Dictyostelium...
EFA86429      605 eweDlsnl---sneeLD---------------AqiklIE-----LEEIELMNEYLQLERNN----NDVIDIRNKL----- 652  Polysphondyli...
XP_004027370   72 ---Kishv----theIN---------------LiktsEQ-----KNETEIEQEYKQLEQEE----EELNQKIFEL----- 115  Ichthyophthir...
XP_012655476   83 iknKieen----eklIN---------------Q-----------SQQQKQKLEIEELKMKE----QQLNQEFEKL----- 123  Tetrahymena t...
XP_002140137  134 --------------dIS---------------IidslIK--------DSLFDNEKDLPDKCnf-nQCIHDNLDYF----- 170  Cryptosporidi...
EKD01414      191 edeEwdal----lkrKE---------------E----LA-----AEEEQLRKQLKEKEDEL----DAVREEERRV----- 233  Trichosporon ...
Q6CLQ7        223 QEEL--A-------KKKDQYIVRLQKQNI-QELEQLTFIKDVQSLKNQRVVTLNHI-DKLRKLNIYNETF----RI---S 284  Kluyveromyces...
Q5CPI7        211 RFQV--IntievddIVELRQNQNLESN---LKHELIQYELKREGMKNHLDFLRGYL-ERLKRSDFLNLSF----YI---- 276  Cryptosporidi...
A0DRK9        101 KNSI--L-------EQEHNEDNLWEHINK-FTRKLYSLFESNQIADNKLSQLNNEL-DRLSKLDVLNDLF----KI---- 161  Paramecium te...
XP_002177919  210 EQELikQ-------ELQATELLVAAERNS-LEVEARAFDNDHEQLCDHLLSIQKEV-ETLSSSQIRWPAFfldvRI---D 277  Phaeodactylum...
XP_003291506  879 EDIL--K-------EIKQEEKTHYDSVNN-YYQEYYDLKQEDEIWDNYISSIKDQI-ERVTQIDIKKAFF----KIagsE 943  Dictyostelium...
EFA86429      653 EDIR--G-------EIKSEEKQHYNNVNH-FYQEYFNLLGQKKSLESQIATMKDDL-DSLSDLNIVKEVF----QItfeK 717  Polysphondyli...
XP_004027370  116 KEKI--L-------TYEQQENEYWDEVNI-FEKNLYQVLEKKQIAENQEKHYNEQL-IKLNTYNTLNQVF----NI---- 176  Ichthyophthir...
XP_012655476  124 KKNV--L-------DFEIRESKYWVEVNS-FEKRLQTLLNKKQIADNLEQYYNDKLnNKLNKYNTINSVF----FI---- 185  Tetrahymena t...
XP_002140137  171 EI------------LVKRQEKEI--RLNNiFKLEYIQRL--IDGTNSDIKFLQYHV-DLLRKINIFNTTF----YI---- 225  Cryptosporidi...
EKD01414      234 KEEE--E-------AIDQEESEFLRTHTA-LSTQLAHLSHTLSTAKTQLLLSSSLL-EHLENTNVYNDAF----QI---G 295  Trichosporon ...
Q6CLQ7        285 H------D--G---PFGTINDLKLGSVPNASVPWSEINSALGQVVLLLSLIAEKLSVSFTDYKLIP-MGSTSSI---EK- 348  Kluyveromyces...
Q5CPI7        277 -------QviE---GGACINGLRPALFEADFDNWNEVNAALGVSAMLLYTILERHKL---PLSIYP-NGSYSTI------ 336  Cryptosporidi...
A0DRK9        162 -------SvqD---EVATINGLQIGKKGEQPVDWDDISAGVGHLTLLLVYLMKKFMYTYQKIESIElNGSFSKIkikDEy 231  Paramecium te...
XP_002177919  278 T------R--Gl--RYPLINDLRLAYRAKGDLSWNEIQTAWSLAAQLLLIVGTIFEFASQEWKIVP-LSHCAKL---IQ- 342  Phaeodactylum...
XP_003291506  944 -------DsnG----IASINGFRLGTLQNLKVDWDEINSAWGETSLLLHVLATQLEYNFLNFKLIP-MGNKSII---QS- 1007 Dictyostelium...
EFA86429      718 I------DehT----IVKINDLRLGTLPKNKVEWDEINGAMGQIVLLVHTIAKQLNYTFTKHKLIP-MGNKPLI---QS- 782  Polysphondyli...
XP_004027370  177 -------QcdE---QAGTINNIIIGKKLNQEIVWDETNAGLGQIAMLFSYLVKKYGYEMKFIKDINlCANESQIc----- 241  Ichthyophthir...
XP_012655476  186 -------EvsE---QVGLINNLMIGKKLNEDINWDETNAGLGQVILLFLYLMNKFGYQSSYIKDIQvCGNESYIc----- 250  Tetrahymena t...
XP_002140137  226 -------NqiN---GIGTINNLRLGLLDNSDENWREINGALGYTSLLLCCIAEKLNI---EVTLNP-YGNYSTItdrCIp 291  Cryptosporidi...
EKD01414      296 HaplaseG--GrsiTVGTINGLRLGGRPN--VDWDEINAAWGLVALCIDRLAAKVGYTFESYKIVP-LGSFSRI---ED- 366  Trichosporon ...
Q6CLQ7        349 ------FDPKTNQwf-vHKAFSG-DEF-S-------FgslFH--KESAIDKALTCIL-EIISLLSAKV---SS-----Ds 401  Kluyveromyces...
Q5CPI7        337 ------KDSESSi----WPLHGNtLCNsD-------Yn------ECTNFDKGILSFV-FLIDTVYNIIpgtNEt------ 386  Cryptosporidi...
A0DRK9        232 qntlctKT---------LNLYLNnKTSqK---------------DEEEFSDAFLQLY-FEFQQFCKYLqdgDIlrkrkIn 286  Paramecium te...
XP_002177919  343 ------YPGGKKQpptvYNIGCS-GKQ-TslallawN---AL--LH------------EIIKDTSEKL---NQ-----Ah 389  Phaeodactylum...
XP_003291506 1008 ------KNDKVS-----YSLYGGdNIQfS-------RsflWFgaSDQRFDNGMEAFL-SCVNEISSFVltkKNi------ 1062 Dictyostelium...
EFA86429      783 ------KSDKEA-----YPLYGGdDIYfR-------S---FIwsREHKFDIGMEAFL-GCINEMCSLF------------ 828  Polysphondyli...
XP_004027370  242 -----eIEKNQI-----LQLYGPlNYQs----------------EYSRFDQAIKLLL-KEFYCFYEFLinqVKigdyvEe 294  Ichthyophthir...
XP_012655476  251 -----eANKSEQ-----LYLRGPfSNKg----------------DEAKFNRAMKMIL-DEFSLFVDYLqqtYL------- 296  Tetrahymena t...
XP_002140137  292 eylsnfVKEEYSi----LPLYGNtSANsN-------Yn------QCIKFDSAIKALL-SNISNIAKYMncsDk------- 346  Cryptosporidi...
EKD01414      367 ------LPPNKGq----YELYWTtGAR-----------------PAAPGERGILSKLfSCHQRTLADVritKD------- 412  Trichosporon ...
Q6CLQ7        402 qdpasiE----------LPYEIl-GD--KING-------LT-ILLNGATpS---LEWTTSCKFLLTNVKWLLAFSTAH 455  Kluyveromyces l...
Q5CPI7        387 -----------------LPYSVd-QRngTIGG-------IS-LNLLFNEr----ESWNRAMSMNLINLKWLLVRSSES 434  Cryptosporidium...
A0DRK9        287 l---------------nLPFTM---NgmSVDNk-----iLS-LKQPAAQkW---QEWTNSVKKFLANVKALIVANaqf 337  Paramecium tetr...
XP_002177919  390 -----kDglldlsvlppLPFAM---AktTIGD-------LNlLRLSPED-D---VRWSQAIQYTATNLQWLSVCTSAH 448  Phaeodactylum t...
XP_003291506 1063 ----------------nFNYRI---NkdKIGDsn---rfYS-IKIASNS-E---AHWTSALKFMLSTLKKILDNLDSi 1113 Dictyostelium p...
EFA86429      829 ------Knv-------vFPFKI---EkdKIGGnn---gfQS-IRVTGNS-E---VNWTKALKYMVTNIKCILTNLnlf 882  Polysphondylium...
XP_004027370  295 v---------------kLPYNId-IQkcEIDY-------VE-ISIMKNI-----DLWTSGMKKFLINFKYIIYINELy 343  Ichthyophthiriu...
XP_012655476  297 ------Qni-------qLPFKId-QSnsSIDGl-----lLT-TQTAANAqYkglDNWTQAFKKLLINFKFLISFNAQY 354  Tetrahymena the...
XP_002140137  347 -----------------LPFIIn-YDmnTIDG-------VS-YNLLFND-K---QTWNNAMKMLLINLKYLIINLCEi 394  Cryptosporidium...
EKD01414      413 ------Kin-------gHPIRMpgLAlpTISSmsimglgGS-TEERSDSaD---EGWTRACRAVLAVLKRILVVESed 473  Trichosporon as...
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