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MAP2K5 mitogen-activated protein kinase kinase 5 [ Homo sapiens (human) ]

Gene ID: 5607, updated on 8-Jul-2018
Official Symbol
MAP2K5provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase 5provided by HGNC
Primary source
HGNC:HGNC:6845
See related
Ensembl:ENSG00000137764 MIM:602520; Vega:OTTHUMG00000133264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEK5; MAPKK5; PRKMK5; HsT17454
Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in ovary (RPKM 2.0), testis (RPKM 1.9) and 25 other tissues See more
Orthologs
See MAP2K5 in Genome Data Viewer
Location:
15q23
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (67542683..67807117)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (67835021..68099455)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene IQ motif containing H Neighboring gene VISTA enhancer hs358 Neighboring gene IQCH antisense RNA 1 Neighboring gene chromosome 15 open reading frame 61 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 5 Neighboring gene uncharacterized LOC107984718 Neighboring gene heart enhancer 7 Neighboring gene uncharacterized LOC105370870 Neighboring gene uncharacterized LOC101929076 Neighboring gene SKI family transcriptional corepressor 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
NHGRI GWA Catalog
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Meta-analysis identifies common variants associated with body mass index in east Asians.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
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  • Cardiac Hypertrophic Response, organism-specific biosystem (from WikiPathways)
    Cardiac Hypertrophic Response, organism-specific biosystemIntegrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response. During development and in response to physiolo...
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  • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
    ErbB1 downstream signaling, organism-specific biosystem
    ErbB1 downstream signaling
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
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    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
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    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • MAPK (ERK5) signaling, organism-specific biosystem (from KEGG)
    MAPK (ERK5) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
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    MAPK (ERK5) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
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  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
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    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
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    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ERK5 cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to laminar fluid shear stress TAS
Traceable Author Statement
more info
PubMed 
heart development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of chemokine (C-X-C motif) ligand 2 production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of heterotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of interleukin-8 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dual specificity mitogen-activated protein kinase kinase 5
Names
MAP kinase kinase 5
MAP kinase kinase MEK5b
MAPK/ERK kinase 5
MAPKK 5
MEK 5
NP_001193733.1
NP_002748.1
NP_660143.1
XP_011520089.1
XP_011520090.1
XP_016877903.1
XP_024305756.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029143.1 RefSeqGene

    Range
    5001..269435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206804.1NP_001193733.1  dual specificity mitogen-activated protein kinase kinase 5 isoform C

    See identical proteins and their annotated locations for NP_001193733.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (C) has a shorter and distinct N-terminus compared to isoform A.
    Source sequence(s)
    AK293459, BC008838, BM682675
    Consensus CDS
    CCDS55970.1
    UniProtKB/Swiss-Prot
    Q13163
    Related
    ENSP00000346493.5, OTTHUMP00000247935, ENST00000354498.9, OTTHUMT00000417498
    Conserved Domains (2) summary
    cd06619
    Location:128406
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    cl02720
    Location:1071
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
  2. NM_002757.3NP_002748.1  dual specificity mitogen-activated protein kinase kinase 5 isoform B

    See identical proteins and their annotated locations for NP_002748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (B) has the same N- and C-termini but is shorter compared to isoform A.
    Source sequence(s)
    AC016355, BC008838, BM682675, DN998338, U71088
    Consensus CDS
    CCDS42051.1
    UniProtKB/Swiss-Prot
    Q13163
    UniProtKB/TrEMBL
    A0A024R5X5
    Related
    ENSP00000378859.2, OTTHUMP00000258033, ENST00000395476.6, OTTHUMT00000439665
    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164432
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
  3. NM_145160.2NP_660143.1  dual specificity mitogen-activated protein kinase kinase 5 isoform A

    See identical proteins and their annotated locations for NP_660143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AC016355, BC008838, BM682675, DN998338
    Consensus CDS
    CCDS10224.1
    UniProtKB/Swiss-Prot
    Q13163
    UniProtKB/TrEMBL
    A0A024R5Y2
    Related
    ENSP00000178640.5, OTTHUMP00000164363, ENST00000178640.9, OTTHUMT00000257041
    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164442
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    67542683..67807117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449988.1XP_024305756.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X1

    Conserved Domains (2) summary
    cd06619
    Location:87365
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    cl02720
    Location:130
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
  2. XM_011521788.3XP_011520090.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X3

    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164282
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011521787.3XP_011520089.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X2

    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164282
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017022414.2XP_016877903.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X4

RNA

  1. XR_001751355.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145161.1: Suppressed sequence

    Description
    NM_145161.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_145162.1: Suppressed sequence

    Description
    NM_145162.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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