Conserved Protein Domain Family
PKc_MKK5

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cd06619: PKc_MKK5 
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK5 (also called MEK5) is a dual-specificity PK that phosphorylates its downstream target, extracellular signal-regulated kinase 5 (ERK5), on specific threonine and tyrosine residues. MKK5 is activated by MEKK2 and MEKK3 in response to mitogenic and stress stimuli. The ERK5 cascade promotes cell proliferation, differentiation, neuronal survival, and neuroprotection. This cascade plays an essential role in heart development. Mice deficient in either ERK5 or MKK5 die around embryonic day 10 due to cardiovascular defects including underdevelopment of the myocardium. In addition, MKK5 is associated with metastasis and unfavorable prognosis in prostate cancer. The MKK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 132950
View PSSM: cd06619
Aligned: 5 rows
Threshold Bit Score: 540.236
Threshold Setting Gi: 156383362
Created: 4-Apr-2007
Updated: 2-Mar-2014
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #####   #                                 # #                           
NP_660143    164 QDIRYRDTLGHGNGGTVYKAYHvp---------------------sgKILAVKVILLDITleLQKQIMSELEILYKCdSS 222 human
BAE48520     164 LDIQCRDILGHGNGGTVYKAYHvp---------------------sgKILAVKVIPLDITveLQRQIMSELEILYKCdSL 222 African clawed ...
CAF99872     114 QDIYYQEQLGHGNGGAVYNLLVplfvptsdieknhhgsvrayhvltrRVFAVKVIPLDITveLQKQIMSELEILYKCdSP 193 Tetraodon nigro...
XP_001632803 151 EQIQHLEILGYGNGGTVYKAIHlt---------------------trRIIAVKVIPLDVTpeVQRQIISEMEISFQCaSP 209 starlet sea ane...
ABQ95653     163 HDLQYQEQLGHGNGGTVYKAYHll---------------------gkRIVAVKVIPLDITveLQKQIMSELEILYKCdSP 221 zebrafish
Feature 1          #               ####  ##  #                               # #### #         ## 
NP_660143    223 YIIGFYGAFFVenRISICTEFMdgGSLDVYRkmPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNtRGQVKLCDF 302 human
BAE48520     223 YIIGFYGAFFVenRISICTEFMdgGSLDVYRkiPEQVLGRIAVAVLKGLTYLWSLKILHRDVKPSNMLVNtRGHVKLCDF 302 African clawed ...
CAF99872     194 YIITFFSAFFVenRISICTEFMdgGSLDVYKkiPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNtRGQVKLCDF 273 Tetraodon nigro...
XP_001632803 210 YIIEFYGAFFVenRISMCTEYMdgGSLDMYGsiPEPVLGRIAVAVVKGLAYLWGLKIMHRDVKPSNILVNtRGQVKLCDF 289 starlet sea ane...
ABQ95653     222 YIIKFYSAFFVenRISICTEFMdgGSLDVYWriPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNtRGQVKLCDF 301 zebrafish
Feature 1         #           #### #                          #        #                         
NP_660143    303 GVSTQLVNSIAKTYVGTNAYMAPERISGeQYGIHSDVWSLGISFMELAlGRFPYPq---------IQKNQGsLMPLQLLQ 373 human
BAE48520     303 GVSTQLVNSIAKTYVGTNAYMAPERIAGeQYGIHSDVWSLGISFMELAlGRFPYPq---------IQKNHGsLMPLQILQ 373 African clawed ...
CAF99872     274 GVSTQLVNSIAKTYVGTNAYMAPERISGeQYGIHADVWSVGISFMELAlGMFPYPq---------IQKNQGsLMPLQLLQ 344 Tetraodon nigro...
XP_001632803 290 GVSRQLVNSIATTYVGTNAYMAPERILGdEYSILSEVWSLGVSLLEMAsGRFPYLkvsiqlasyfFFGNHCfLVPIELLQ 369 starlet sea ane...
ABQ95653     302 GVSTQLVNSIAKTYVGTNAYMAPERISGeQYGIHSDVWSVGISFMELAlGSFPYPq---------IQKNQGsLMPLQLLQ 372 zebrafish
Feature 1                                                                             
NP_660143    374 CIVDEDSPVLPVGeFSEPFVHFITQCMRKqPKERPApEELMGHPFIVQFNDGNAAVVSMWVCRALEERR 442 human
BAE48520     374 CIVDEECPVLPVGeFSESFVHFITQCMRKpPKERPApEMLMDHPFIVQFNDGNTEAVSMWVCRALEERR 442 African clawed frog
CAF99872     345 CIVDEDPPVLPVGqFSDKFIHFITQCMRRqPKERPApNNLMDHSFIVQYNDGNAEVVSMWVCRCLEERR 413 Tetraodon nigroviridis
XP_001632803 370 CIVHEAPPRLPDHlFSPVFVDFVAQCMQKsPSTRLTpEAVLDHIFIRMSDDGNIDMISMWVCRRLEEKR 438 starlet sea anemone
ABQ95653     373 CIVDEDPPVLPVGqFSEKFVHFITQCMRKlPKERPApNNLMDHPFIVQYNDGNTEVVSMWVCRSLEDRK 441 zebrafish

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