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Map2k5 mitogen-activated protein kinase kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 23938, updated on 5-Mar-2024

Summary

Official Symbol
Map2k5provided by MGI
Official Full Name
mitogen-activated protein kinase kinase 5provided by MGI
Primary source
MGI:MGI:1346345
See related
Ensembl:ENSMUSG00000058444 AllianceGenome:MGI:1346345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MEK5; Mapkk5; Prkmk5
Summary
Predicted to enable ATP binding activity and MAP kinase kinase activity. Acts upstream of or within MAPK cascade and heart development. Located in spindle. Is expressed in early conceptus; oocyte; and telencephalon. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 10.5), thymus adult (RPKM 8.4) and 28 other tissues See more
Orthologs
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Genomic context

See Map2k5 in Genome Data Viewer
Location:
9 B- C; 9 33.96 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (63071050..63288964, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (63163768..63381682, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E713 Neighboring gene predicted gene, 25064 Neighboring gene SKI family transcriptional corepressor 1 Neighboring gene predicted gene, 39355 Neighboring gene STARR-positive B cell enhancer ABC_E5077 Neighboring gene RIKEN cDNA 2300009A05 gene Neighboring gene STARR-positive B cell enhancer mm9_chr9:63247761-63248062 Neighboring gene predicted gene, 16759 Neighboring gene IQ motif containing H Neighboring gene predicted gene, 25995

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ERK5 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 5
Names
MAP kinase kinase 5
MAPK/ERK kinase 5
NP_001351421.1
NP_001351422.1
NP_001351423.1
NP_035970.1
XP_006511209.1
XP_011241042.1
XP_030100214.1
XP_036010824.1
XP_036010825.1
XP_036010826.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364492.1NP_001351421.1  dual specificity mitogen-activated protein kinase kinase 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124753
    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164186
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001364493.1NP_001351422.1  dual specificity mitogen-activated protein kinase kinase 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124753, AC160392
    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164433
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
  3. NM_001364494.1NP_001351423.1  dual specificity mitogen-activated protein kinase kinase 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124753, AC160392
    Conserved Domains (1) summary
    cd06619
    Location:75353
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
  4. NM_011840.3NP_035970.1  dual specificity mitogen-activated protein kinase kinase 5 isoform 1

    See identical proteins and their annotated locations for NP_035970.1

    Status: VALIDATED

    Source sequence(s)
    AC124753, AC160392
    Consensus CDS
    CCDS23269.1
    UniProtKB/Swiss-Prot
    Q8CFM3, Q8K360, Q9D222, Q9WVS7
    Related
    ENSMUSP00000034920.10, ENSMUST00000034920.11
    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164442
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    63071050..63288964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154933.1XP_036010826.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X5

    Conserved Domains (1) summary
    cd06619
    Location:4282
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
  2. XM_006511146.2XP_006511209.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X1

    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164432
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
  3. XM_036154932.1XP_036010825.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X4

    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164369
    PKc_like; Protein Kinases, catalytic domain
  4. XM_036154931.1XP_036010824.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X3

    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164378
    PKc_like; Protein Kinases, catalytic domain
  5. XM_030244354.1XP_030100214.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X5

    Conserved Domains (1) summary
    cd06619
    Location:4282
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
  6. XM_011242740.4XP_011241042.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X2

    Conserved Domains (2) summary
    cd06395
    Location:17107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164419
    PKc_like; Protein Kinases, catalytic domain