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MAPK7 mitogen-activated protein kinase 7 [ Homo sapiens (human) ]

Gene ID: 5598, updated on 12-Sep-2020

Summary

Official Symbol
MAPK7provided by HGNC
Official Full Name
mitogen-activated protein kinase 7provided by HGNC
Primary source
HGNC:HGNC:6880
See related
Ensembl:ENSG00000166484 MIM:602521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMK1; ERK4; ERK5; PRKM7
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues See more
Orthologs

Genomic context

See MAPK7 in Genome Data Viewer
Location:
17p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (19377721..19383544)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19281034..19286857)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene B9 domain containing 1 Neighboring gene microRNA 1180 Neighboring gene uncharacterized LOC105371573 Neighboring gene microfibril associated protein 4 Neighboring gene ring finger protein 112 Neighboring gene uncharacterized LOC105371574 Neighboring gene long intergenic non-protein coding RNA 2094

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
cAMP-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to laminar fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to laminar fluid shear stress TAS
Traceable Author Statement
more info
PubMed 
cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cyclic-nucleotide phosphodiesterase activity NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of heterotypic cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of response to cytokine stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 7
Names
BMK-1
BMK1 kinase
ERK-5
MAP kinase 7
MAPK 7
big MAP kinase 1
extracellular-signal-regulated kinase 5
NP_002740.2
NP_620601.1
NP_620602.2
NP_620603.2
XP_006721620.1
XP_006721621.1
XP_006721622.1
XP_011522259.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002749.4NP_002740.2  mitogen-activated protein kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_002740.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is also known as BMK1 gamma. It differs in the 5' UTR, as compared to variant 1. Variants 1, 3 and 4 encode the same isoform.
    Source sequence(s)
    BC009963, BC030134, DA452383
    Consensus CDS
    CCDS11206.1
    UniProtKB/Swiss-Prot
    Q13164
    UniProtKB/TrEMBL
    A0A024QZ20
    Related
    ENSP00000378968.3, ENST00000395604.8
    Conserved Domains (2) summary
    smart00220
    Location:55347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
  2. NM_139032.3NP_620601.1  mitogen-activated protein kinase 7 isoform 2

    See identical proteins and their annotated locations for NP_620601.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' region, which includes the translation start codon, when compared to variant 1. The translation of this transcript begins at a downstream in-frame start codon, and thus results in an N-terminal truncated isoform (2), as compared to isoform 1.
    Source sequence(s)
    BC007404, BC030134, DB133227
    Consensus CDS
    CCDS11207.1
    UniProtKB/Swiss-Prot
    Q13164
    Related
    ENSP00000299612.7, ENST00000299612.11
    Conserved Domains (2) summary
    smart00220
    Location:4208
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1245
    PKc_like; Protein Kinases, catalytic domain
  3. NM_139033.3NP_620602.2  mitogen-activated protein kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_620602.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is also known as BMK1 alpha. It encodes a longer isoform (1), as compared to variant 2. Variants 1, 3 and 4 encode the same isoform.
    Source sequence(s)
    BC030134, DB133227, U29725
    Consensus CDS
    CCDS11206.1
    UniProtKB/Swiss-Prot
    Q13164
    UniProtKB/TrEMBL
    A0A024QZ20
    Related
    ENSP00000311005.5, ENST00000308406.9
    Conserved Domains (2) summary
    smart00220
    Location:55347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
  4. NM_139034.3NP_620603.2  mitogen-activated protein kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_620603.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is also known as BMK1 beta. It differs in the 5' UTR, as compared to variant 1. Variants 1, 3 and 4 encode the same isoform.
    Source sequence(s)
    BC030134, U29726
    Consensus CDS
    CCDS11206.1
    UniProtKB/Swiss-Prot
    Q13164
    UniProtKB/TrEMBL
    A0A024QZ20
    Related
    ENSP00000378966.4, ENST00000395602.8
    Conserved Domains (2) summary
    smart00220
    Location:55347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    19377721..19383544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721558.3XP_006721621.1  mitogen-activated protein kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_006721621.1

    Conserved Domains (2) summary
    smart00220
    Location:55353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49390
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
  2. XM_011523957.3XP_011522259.1  mitogen-activated protein kinase 7 isoform X2

    See identical proteins and their annotated locations for XP_011522259.1

    UniProtKB/Swiss-Prot
    Q13164
    Conserved Domains (2) summary
    smart00220
    Location:4208
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1245
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006721559.3XP_006721622.1  mitogen-activated protein kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_006721622.1

    Conserved Domains (2) summary
    smart00220
    Location:55353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49390
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
  4. XM_006721557.3XP_006721620.1  mitogen-activated protein kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_006721620.1

    Conserved Domains (2) summary
    smart00220
    Location:55353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:49390
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
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