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MAPK1 mitogen-activated protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 5594, updated on 20-Jun-2021

Summary

Official Symbol
MAPK1provided by HGNC
Official Full Name
mitogen-activated protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:6871
See related
Ensembl:ENSG00000100030 MIM:176948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERK; p38; p40; p41; ERK2; ERT1; NS13; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK
Summary
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in brain (RPKM 63.3), thyroid (RPKM 32.9) and 25 other tissues See more
Orthologs
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Genomic context

See MAPK1 in Genome Data Viewer
Location:
22q11.22
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (21759657..21867680, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22113946..22221970, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 2 Neighboring gene yippee like 1 Neighboring gene RNA, 7SL, cytoplasmic 280, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 493 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1F Neighboring gene PPM1F antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 76 Neighboring gene DNA topoisomerase III beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Noonan syndrome 13
MedGen: C5436773 OMIM: 619087 GeneReviews: Not available
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HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ERK2 by siRNA decreases incorporation of ERK2 into virions, leading to the decreased infectivity of the ERK2-defective virus in TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) binds to CD209 (DC-SIGN), which activates NFKB1 (NF-kB), MAPK1 (ERK1/2), and MAPK14 (p38) PubMed
env HIV-1 CN54 Env (gp120) induces phosphorylation of RELA (p65), IRF3, MAPK14 (p38), and MAPK1 (ERK1/2) through TLR4 induction in monocyte derived macrophages; anti-TLR4 antibodies could inhibit this activation PubMed
env HIV-1 gp120 induces activation of the ERK1/2 MAPK signaling pathway in polarized oral epithelial cells PubMed
env HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38 PubMed
env HIV-1 gp120 induces nuclear localization of the phosphoinositide-specific phospholipase C (PI-PLC) beta 1 isozyme in MDMs, which requires activation of the MAPK ERK1/2 pathway PubMed
env HIV-1 gp120-induced phosphatidylcholine-specific phospholipase D (PLD) activity is dependent on the activation of ERK1/2 PubMed
env Treatment of cells with HIV-1 gp120 induces increased levels of endogenous c-fos and c-jun mRNA and proteins, an activation of both c-fos and c-jun promoters, and a very rapid stimulation of the MAPK/ERK pathway PubMed
env NHERF1 increases ERK1/2 phosphorylation levels following HIV-1 gp120 stimulation in cells PubMed
env HIV-1 X4-tropic gp120 upregulates alpha-SMA (ACTA2) and collagen I alpha 1 expression via the ERK1/2 pathway in a CXCR4-dependent manner in activated human hepatic stellate cells PubMed
env Stimulation of human monocyte-derived macrophages with HIV-1 gp120 results in the CCR5-mediated activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2, which leads to production of TNF-alpha PubMed
env HIV-1 gp120 induces IL-10 expression in monocyte-derived dendritic cells via a mannose C-type lectin receptor and an ERK signaling pathway PubMed
env HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in macrophages and primary human central nervous system (CNS) cells PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK PubMed
Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
env Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin PubMed
Envelope transmembrane glycoprotein gp41 env The HIV-1 gp41 transmembrane domain inhibits TLR2-induced activation of ERK1/2, and secretion of TNF-alpha, MCP-1, and IL-6 PubMed
env HIV-1 gp41 is able to activate the ERK/MAPK pathway by binding to CD74 PubMed
Nef nef HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 PubMed
nef HIV-1 Nef induces phosphorylation of MAPK1 (ERK2) in M2-type macrophages PubMed
nef HIV-1 Nef expression in a human astrocytic cell line inhibits the endothelin-1 mediated activation of ERK1 and ERK2 activity PubMed
nef The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation PubMed
nef HIV-1 Nef causes the FMS N-glycosylation defect and induces relocalization of the GM130 by activating the p56Hck/MEK/ERK/GRASP65 phosphorylation cascade in the Golgi PubMed
nef HIV-1 Nef-induced relocalization of LCK increases phosphorylated ERK1/2 induction in infected and trasduced primary T cells PubMed
nef Formation of the Nef-associated kinase complex (NAKC) is sufficient to activate LCK and ERK1/2 and causes a strong Tat-dependent increase of HIV-1 transcription in T cells PubMed
nef The formation of Nef/LCK/PKCtheta complex activates the ERK MAPK signaling pathway PubMed
nef HIV-1 Nef and ALK are capable of cumulatively influencing the MAP-K phosphorylation in astrocytic glioma cells PubMed
nef HIV-1 Nef upregulates ICAM-1 expression on endothelial cells via Erk /Mapk signaling pathway PubMed
nef A proline-rich repeat sequence [(Pxx)4] in HIV-1 Nef occurring between amino acid residues 69 to 78 binds to MAPK and significantly decreases its kinase activity in vitro PubMed
nef HIV-1 Nef, through its PxxP and RR106 motifs, upregulates Src kinase activity and signal transducer and activator of transcription 3 (Stat3) phosphorylation, and activates the Ras-c-Raf-MAPK1,2 pathway in podocytes PubMed
nef HIV-1 Nef induces ERK/MAPK signaling, which is essential for Nef-mediated Bcl-XL upregulation and cell survival in TF-1 macrophages cells PubMed
nef In human and murine monocyte-macrophages, HIV-1 Nef induces both DNA binding and transcriptional activities of the activator protein-1 (AP-1) through an association with ERK1 and 2 signaling pathways PubMed
nef HIV-1 Nef-induced Fas ligand transcription is regulated by p38 MAPK-mediated activator protein-1 (AP-1) activation PubMed
nef HIV-1 Nef expression in primary CD4 T cells upregulates ERK, MEK, and Elk induction in a T cell receptor stimulation dependent manner, leading to enhanced viral replication and infectivity PubMed
nef Phospho-MAPK1,2 and phospho-Stat3 staining increase in podocytes of kidneys from HIV-associated nephropathy patients, suggesting HIV-1 Nef-induced activation of these pathways is responsible for podocyte proliferation and dedifferentiation PubMed
nef MAPK and JNK activities are activated in the presence of HIV-1 Nef after TNF-alpha treatment in human glial cells PubMed
nef The activation of extracellular signal-regulated kinase 2 (ERK2) by endothelin-1 (ET-1) is inhibited by HIV-1 Nef in human astrocytes; a similar inhibitory action of Nef on ERK2 activation was observed after direct stimulation of G proteins PubMed
Pr55(Gag) gag ERK2 phosphorylates HIV-1 CA at position Ser16 residue after the initiation of HIV-1 Gag processing by HIV-1 PR PubMed
gag The CA region of HIV-1 Gag interacts with MAPK/ERK2 and sequentially encapsidates MAPK/ERK2 into virus particles. A domain comprising amino acids 56-110 in CA is critical for Gag interaction with MAPK/ERK2 PubMed
gag The p6 protein of HIV-1 Gag is phosphorylated by cellular kinases with ERK1 and ERK2 being the most likely kinases involved in p6 phosphorylation PubMed
gag Phosphorylation of the Matrix protein of HIV-1 Gag on tyrosine and serine facilitates dissociation of Matrix from the cellular membrane, thus allowing it to translocate to the nucleus and participate in HIV-1 nuclear import PubMed
gag Recombinant MAPK phosphorylates the Matrix protein of HIV-1 Gag on serine and threonine residues, whereas immunoprecipitated MAPK predominantly phosphorylates Matrix on serine residues PubMed
Rev rev MAPK has been shown to phosphorylate Rev in vitro PubMed
Tat tat HIV-1 Tat protein activates RELA (p65), MAP kinases ERK1/2 and p38, and PKC-bII in a TLR4-dependent manner in human monocytes PubMed
tat HIV-1 Tat activates PRKCQ (PKC-theta) kinase activity, which leads to RELA (NFkB), NRAS, RAF1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK3 (ERK1), and MAPK1 (ERK2) activation, in Jurkat T cells that stably express Tat PubMed
tat HIV-1 Tat induces phosphorylation of MAPK1 (ERK2) in CRT-MG human astroglioma cells PubMed
tat HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes PubMed
tat Treatment with HIV-1 Tat induces phosphorylation of ERK1/2 and JNK in brain micro vascular endothelial cells (BMEC) and astrocytes, which mediates Tat-induced multidrug resistance-associated protein 1 (MRP1) expression PubMed
tat Blocking HIV-1 Tat and cocaine-mediated Erk activation reverses ZO-1 downregulation in human pulmonary artery endothelial cells PubMed
tat Treatment with HIV-1 Tat and cocaine activates Ras/Erk pathway in human pulmonary artery endothelial cells PubMed
tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
tat The basic domain (49RKKRRQRRR57) of HIV-1 Tat is essential for enhancing the FGF-induced activation of ERK, Rho-A, and MLC2 and upregulates the expression of MMP-9 in human podocytes PubMed
tat HIV-1 Tat induces activation of the ERK1/2 MAPK signaling pathway in polarized oral epithelial cells PubMed
tat HIV-1 Tat- and oxovanadate-treated microglial cells synergistically induce release of TNF-alpha and IL-1beta proteins, which involves CD45 and ERK1/2 signaling pathways PubMed
tat HIV-1 Tat induces ERK phosphorylation by the activation of the small GTPase Ras, but not the small GTPase Rac, in human endothelial cells PubMed
tat Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38 PubMed
tat HIV-1 Tat-induced upregulation of B7-H1 protein expression requires activation of the ERK/MAPK signaling pathway in human endothelial cells PubMed
tat HIV-1 Tat and morphine-induced apoptosis in human neuroblastoma cells involves ERK1/2 and JNK activation PubMed
tat Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2 PubMed
tat HIV-1 Tat-linked intracellular third loop of the endothelin-1 type B receptor markedly enhances the endothelin-1 activation of ERK in the bone morphogenetic protein-2 receptor human pulmonary artery smooth muscle cells PubMed
tat The NADPH oxidase inhibitors DPI and apocynin abrogate HIV-1 Tat-stimulated ERK1/2 activation in human microglia-like cells PubMed
tat HIV-1 Tat inhibits the LPS-activation of ERK1/2 but not the p38 mitogen-activated protein kinases in primary blood monocytes/macrophages PubMed
tat Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat PubMed
tat Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3 PubMed
tat Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor PubMed
tat Formation of the Nef-associated kinase complex (NAKC) is sufficient to activate LCK and ERK1/2 and causes a strong Tat-dependent increase of HIV-1 transcription in T cells PubMed
tat HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1) PubMed
tat Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 PubMed
tat Sulfated polymannuroguluronate (SPMG) blocks the Tat-induced extracellular-signal regulated kinase 1/2- and c-jun amino-terminal kinase-mediated signalling pathways PubMed
tat The binding between HIV-1 Tat and Grb2 is mediated by the proline-rich sequence (residues 1-18) of Tat and the SH3 domain (residues 160-212) of Grb2, which impairs activation of the Raf/MAPK pathway and increases the PKA/Raf inhibitory pathway PubMed
tat HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
tat HIV-1 Tat alters the properties of human neural precursor cells via attenuation of the cell cycle regulatory unit cyclin D1 and the mitogen-activated protein kinase (MAPK) pathway, particularly extracellular signal-related kinase 1/2 (ERK1/2) PubMed
tat HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT) PubMed
tat HIV-1 Tat activates ERK1 and ERK2 through the activation of MEK1 and MEK2, leading to induction of IL-8, IL-10, IP-10, iNOS, superoxide and TNF-alpha, as well as suppression of p35 activator of cdk5, activation of CREB and increased albumin permeability PubMed
tat Expression of HIV-1 Tat in human SK-N-MC cells inhibits the NGF-signaling pathway leading to suppression of MAPK and reduction of Puralpha binding to the Egr-1 promoter PubMed
tat HIV-1 Tat is phosphorylated by MAPK in vitro PubMed
tat The interaction of HIV-1 Tat with KDR/VEGFR2 is implicated in the activation of ERK1 and ERK2 signaling pathways PubMed
Vif vif MAPK phosphorylates HIV-1 Vif on Thr96 and Ser165 and is important in the regulation of HIV-1 infectivity by Vif PubMed
Vpr vpr HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation PubMed
capsid gag ERK2 is incorporated into newly formed viral particles via its interaction with HIV-1 Gag and phosphorylates HIV-1 CA at Ser16 residue in virions. ERK2-packaging-defective virus exhibits lower infectivity than control virus PubMed
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that MAPK1 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with MAPK1 PubMed
matrix gag HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways PubMed
gag HIV-1 p17 variant S75X shows a similar activity to p17delta36 in modulating ERK1/2 signalling pathway in Raji and human primary B cells PubMed
gag Expression of Pokeweed antiviral protein (PAP), a plant-derived N-glycosidase, activates the ERK1/2 MAPK pathway to a limited extent, resulting in increased phosphorylation of HIV-1 MA PubMed
gag HIV-1 p17 induces phosphorylation of ERK1/ERK2 in human endothelial cells PubMed
gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed
gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
gag Phosphorylation of HIV-1 Matrix on tyrosine and serine prior to and during virus infection facilitates dissociation of Matrix from the cellular membrane, thus allowing it to translocate to the nucleus and participate in HIV-1 nuclear import PubMed
gag Recombinant MAPK phosphorylates HIV-1 Matrix on serine and threonine residues, whereas immunoprecipitated MAPK predominantly phosphorylates HIV-1 Matrix on serine residues PubMed
p6 gag HIV-1 p6-Gag is phosphorylated by cellular kinases with ERK1 and ERK2 being the most likely kinases involved in p6 phosphorylation PubMed
reverse transcriptase gag-pol MEK1 in HIV-1 producer cells is able to activate virion-associated MAPK in trans, and the activated MAPK facilitates efficient disengagement of the HIV-1 reverse transcription complex from the cell membrane and subsequent nuclear translocation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mitogen-activated protein kinase kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Bergmann glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in ERBB signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ERK1 and ERK2 cascade TAS
Traceable Author Statement
more info
 
involved_in Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
involved_in MAPK cascade TAS
Traceable Author Statement
more info
 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of MAPK activity TAS
Traceable Author Statement
more info
 
involved_in activation of MAPKK activity TAS
Traceable Author Statement
more info
 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance TAS
Traceable Author Statement
more info
 
involved_in cardiac neural crest cell development involved in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in caveolin-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to dopamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in cytosine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in decidualization IEA
Inferred from Electronic Annotation
more info
 
involved_in diadenosine tetraphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in face development IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
involved_in learning or memory NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation by symbiont of host apoptotic process TAS
Traceable Author Statement
more info
 
involved_in negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in neutrophil degranulation TAS
Traceable Author Statement
more info
 
involved_in outer ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in platelet activation TAS
Traceable Author Statement
more info
 
involved_in positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of macrophage chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of positive regulation of macrophage proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 
involved_in regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cellular pH IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
involved_in regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
involved_in regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in response to epidermal growth factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to estrogen IEA
Inferred from Electronic Annotation
more info
 
involved_in response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nicotine ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thymus development IEA
Inferred from Electronic Annotation
more info
 
involved_in thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in trachea formation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
 
located_in caveola ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in caveola TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in focal adhesion TAS
Traceable Author Statement
more info
PubMed 
located_in late endosome TAS
Traceable Author Statement
more info
PubMed 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
located_in mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
located_in pseudopodium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 1
Names
MAP kinase 1
MAP kinase 2
MAPK 2
extracellular signal-regulated kinase 2
mitogen-activated protein kinase 2
protein tyrosine kinase ERK2
NP_002736.3
NP_620407.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023054.2 RefSeqGene

    Range
    5001..113024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_786

mRNA and Protein(s)

  1. NM_002745.5NP_002736.3  mitogen-activated protein kinase 1

    See identical proteins and their annotated locations for NP_002736.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP000553, AP000554, AP000555, BC017832, BC099905
    Consensus CDS
    CCDS13795.1
    UniProtKB/Swiss-Prot
    P28482
    UniProtKB/TrEMBL
    Q1HBJ4, Q499G7
    Related
    ENSP00000215832.7, ENST00000215832.11
    Conserved Domains (1) summary
    cd07849
    Location:19353
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  2. NM_138957.3NP_620407.1  mitogen-activated protein kinase 1

    See identical proteins and their annotated locations for NP_620407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different 3' UTR region, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC017832, BQ774391
    Consensus CDS
    CCDS13795.1
    UniProtKB/Swiss-Prot
    P28482
    UniProtKB/TrEMBL
    Q1HBJ4
    Related
    ENSP00000381803.3, ENST00000398822.7
    Conserved Domains (1) summary
    cd07849
    Location:19353
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    21759657..21867680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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