Format

Send to:

Choose Destination

Mapk1 mitogen-activated protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 26413, updated on 7-Oct-2018

Summary

Official Symbol
Mapk1provided by MGI
Official Full Name
mitogen-activated protein kinase 1provided by MGI
Primary source
MGI:MGI:1346858
See related
Ensembl:ENSMUSG00000063358 Vega:OTTMUSG00000020203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERK; Erk2; MAPK2; PRKM2; Prkm1; C78273; p41mapk; p42mapk; AA407128; AU018647; 9030612K14Rik
Expression
Ubiquitous expression in frontal lobe adult (RPKM 69.7), cortex adult (RPKM 53.9) and 28 other tissues See more
Orthologs

Genomic context

See Mapk1 in Genome Data Viewer
Location:
16 A3; 16 10.53 cM
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (16983379..17047453)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (16983475..17047546)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S21, mitochondrial pseudogene Neighboring gene predicted gene 6438 Neighboring gene yippee like 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 Neighboring gene RIKEN cDNA 2610318N02 gene Neighboring gene microRNA 130b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II CTD heptapeptide repeat kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Bergmann glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
ERBB signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
animal organ morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cardiac neural crest cell development involved in heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
caveolin-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to dopamine ISO
Inferred from Sequence Orthology
more info
 
cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor IGI
Inferred from Genetic Interaction
more info
PubMed 
cytosine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
diadenosine tetraphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
face development IGI
Inferred from Genetic Interaction
more info
PubMed 
face development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
mammary gland epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
neural crest cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
outer ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
regulation of cellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ossification IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
response to epidermal growth factor ISO
Inferred from Sequence Orthology
more info
 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
response to nicotine IGI
Inferred from Genetic Interaction
more info
PubMed 
response to nicotine ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
trachea formation IGI
Inferred from Genetic Interaction
more info
PubMed 
transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
caveola TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
early endosome TAS
Traceable Author Statement
more info
PubMed 
focal adhesion TAS
Traceable Author Statement
more info
PubMed 
late endosome TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 1
Names
ERK-2
ERT1
MAP kinase 1
MAP kinase 2
MAP kinase isoform p42
MAPK 1
MAPK 2
extracellular signal-regulated kinase 2
mitogen-activated protein kinase 2
p42-MAPK
NP_001033752.1
NP_036079.1
XP_006522210.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038663.1NP_001033752.1  mitogen-activated protein kinase 1

    See identical proteins and their annotated locations for NP_001033752.1

    Status: VALIDATED

    Source sequence(s)
    BB648734, D10939
    Consensus CDS
    CCDS27992.1
    UniProtKB/Swiss-Prot
    P63085
    Related
    ENSMUSP00000111396.1, OTTMUSP00000022010, ENSMUST00000115731.9, OTTMUST00000048169
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  2. NM_001357115.1NP_001344044.1  mitogen-activated protein kinase 1

    Status: VALIDATED

    Source sequence(s)
    AC166346, AC166832
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  3. NM_011949.3NP_036079.1  mitogen-activated protein kinase 1

    See identical proteins and their annotated locations for NP_036079.1

    Status: VALIDATED

    Source sequence(s)
    AC154667, AK132241, BB648734
    Consensus CDS
    CCDS27992.1
    UniProtKB/Swiss-Prot
    P63085
    Related
    ENSMUSP00000065983.7, OTTMUSP00000021888, ENSMUST00000069107.13, OTTMUST00000047990
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    16983379..17047453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522147.3XP_006522210.1  mitogen-activated protein kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    P63085
    Related
    ENSMUSP00000156154.1, OTTMUSP00000022009, ENSMUST00000232611.1, OTTMUST00000048168
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
Support Center