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WSB2 WD repeat and SOCS box containing 2 [ Homo sapiens (human) ]

Gene ID: 55884, updated on 13-Mar-2020

Summary

Official Symbol
WSB2provided by HGNC
Official Full Name
WD repeat and SOCS box containing 2provided by HGNC
Primary source
HGNC:HGNC:19222
See related
Ensembl:ENSG00000176871
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBA2
Summary
This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 28.5) and 25 other tissues See more
Orthologs

Genomic context

See WSB2 in Genome Data Viewer
Location:
12q24.23
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (118032687..118062430, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118470492..118499979, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11046 Neighboring gene kinase suppressor of ras 2 Neighboring gene uncharacterized LOC105370011 Neighboring gene replication factor C subunit 5 Neighboring gene uncharacterized LOC101928274 Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene Sharpr-MPRA regulatory region 576

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of WD repeat and SOCS box containing 2 (WSB2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10210

Gene Ontology Provided by GOA

Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
WD repeat and SOCS box-containing protein 2
Names
CS box-containing WD protein
WSB-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278557.1NP_001265486.1  WD repeat and SOCS box-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001265486.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC131159, AF229181, AK295555, CA443120
    Consensus CDS
    CCDS61252.1
    UniProtKB/Swiss-Prot
    Q9NYS7
    Related
    ENSP00000409131.2, ENST00000441406.6
    Conserved Domains (4) summary
    COG2319
    Location:47384
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:138377
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd03733
    Location:381419
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:174212
    7WD40; WD40 repeat [structural motif]
  2. NM_001278558.1NP_001265487.1  WD repeat and SOCS box-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001265487.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks two internal exons compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC131159, AF229181, AK298513, CA443120, DA772463
    Consensus CDS
    CCDS61251.1
    UniProtKB/Swiss-Prot
    Q9NYS7
    Related
    ENSP00000444431.1, ENST00000544233.5
    Conserved Domains (3) summary
    cd03733
    Location:154192
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:3268
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:1150
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_018639.5NP_061109.1  WD repeat and SOCS box-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_061109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC131159, AF229181, CA443120, DA772463
    Consensus CDS
    CCDS9186.1
    UniProtKB/Swiss-Prot
    Q9NYS7
    Related
    ENSP00000319474.3, ENST00000315436.7
    Conserved Domains (3) summary
    cd00200
    Location:121360
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd03733
    Location:364402
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:157195
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    118032687..118062430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019642.1XP_016875131.1  WD repeat and SOCS box-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NYS7
    Conserved Domains (3) summary
    cd03733
    Location:154192
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:3268
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:1150
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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