Wsb2 WD repeat and SOCS box-containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wsb2provided by MGI
Official Full Name: WD repeat and SOCS box-containing 2provided by MGI
Primary source: MGI:MGI:2144041
See related: Ensembl:ENSMUSG00000029364 AllianceGenome:MGI:2144041
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Swip2; WSB-2
Summary: Predicted to be involved in intracellular signal transduction. Is expressed in several structures, including central nervous system; gonad; lung; stomach; and urinary system. Orthologous to human WSB2 (WD repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 87.6), cortex adult (RPKM 80.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.88 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (117495370..117516666)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (117357305..117378601)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wsb-2 binding to the G-CSF-R reduced its cell surface expression and inhibited proliferation signaling.
Title: Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124346 (e-PCR)
- UniSTS:161168

RH135831 (e-PCR)
- UniSTS:209829

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: WD repeat and SOCS box-containing protein 2

Names: SOCS box-containing WD protein SWiP-2; WD-40-repeat-containing protein with a SOCS box 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021539.5 → NP_067514.2 WD repeat and SOCS box-containing protein 2

See identical proteins and their annotated locations for NP_067514.2

Status: VALIDATED

Source sequence(s)

AC110234, AC113299

Consensus CDS

CCDS19604.1

UniProtKB/Swiss-Prot

O54929, Q6GTI7, Q9R1M8

UniProtKB/TrEMBL

E9Q8J9

Related

ENSMUSP00000031309.10, ENSMUST00000031309.16

Conserved Domains (4) summary

cd00200
Location:121 → 360

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd03733
Location:364 → 402

SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...

sd00039
Location:157 → 195

7WD40; WD40 repeat [structural motif]

cl25539
Location:30 → 182

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

117495370..117516666

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254744.2 → XP_030110604.1 WD repeat and SOCS box-containing protein 2 isoform X1

Conserved Domains (3) summary

cd03733
Location:154 → 192

SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...

sd00039
Location:32 → 73

7WD40; WD40 repeat [structural motif]

cl29593
Location:1 → 150

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...