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Wsb2 WD repeat and SOCS box-containing 2 [ Mus musculus (house mouse) ]

Gene ID: 59043, updated on 26-Sep-2022

Summary

Official Symbol
Wsb2provided by MGI
Official Full Name
WD repeat and SOCS box-containing 2provided by MGI
Primary source
MGI:MGI:2144041
See related
Ensembl:ENSMUSG00000029364 AllianceGenome:MGI:2144041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Swip2; WSB-2
Summary
Predicted to be involved in intracellular signal transduction. Is expressed in several structures, including central nervous system; gonad; lung; stomach; and urinary system. Orthologous to human WSB2 (WD repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 87.6), cortex adult (RPKM 80.5) and 28 other tissues See more
Orthologs
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Genomic context

See Wsb2 in Genome Data Viewer
Location:
5; 5 F
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117495370..117516666)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117357305..117378601)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene 60S ribosomal protein L27a pseudogene Neighboring gene predicted gene, 42012 Neighboring gene replication factor C (activator 1) 5 Neighboring gene predicted gene 15728

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
WD repeat and SOCS box-containing protein 2
Names
SOCS box-containing WD protein SWiP-2
WD-40-repeat-containing protein with a SOCS box 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021539.5NP_067514.2  WD repeat and SOCS box-containing protein 2

    See identical proteins and their annotated locations for NP_067514.2

    Status: VALIDATED

    Source sequence(s)
    AC110234, AC113299
    Consensus CDS
    CCDS19604.1
    UniProtKB/Swiss-Prot
    O54929, Q9R1M8
    UniProtKB/TrEMBL
    A0A6P5PNM2
    Related
    ENSMUSP00000031309.10, ENSMUST00000031309.16
    Conserved Domains (4) summary
    cd00200
    Location:121360
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd03733
    Location:364402
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:157195
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:30182
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    117495370..117516666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254744.2XP_030110604.1  WD repeat and SOCS box-containing protein 2 isoform X1

    Conserved Domains (3) summary
    cd03733
    Location:154192
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:3273
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:1150
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...