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USE1 unconventional SNARE in the ER 1 [ Homo sapiens (human) ]

Gene ID: 55850, updated on 8-Jul-2021

Summary

Official Symbol
USE1provided by HGNC
Official Full Name
unconventional SNARE in the ER 1provided by HGNC
Primary source
HGNC:HGNC:30882
See related
Ensembl:ENSG00000053501 MIM:610675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D12; P31; SLT1; MDS032
Expression
Ubiquitous expression in brain (RPKM 7.1), fat (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

See USE1 in Genome Data Viewer
Location:
19p13.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17215346..17219831)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17326166..17330638)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene HAUS augmin like complex subunit 8 Neighboring gene myosin IXB Neighboring gene small nucleolar RNA, H/ACA box 118 Neighboring gene occludin/ELL domain containing 1 Neighboring gene nuclear receptor subfamily 2 group F member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of unconventional SNARE in the ER 1 homolog (USE1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in lysosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in secretion by cell ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in COPI-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
NOT located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
vesicle transport protein USE1
Names
Q-SNARE
SNARE-like tail-anchored protein 1 homolog
USE1-like protein
protein p31
putative MAPK activating protein PM26
unconventional SNARE in the ER 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018467.4NP_060937.2  vesicle transport protein USE1

    Status: VALIDATED

    Source sequence(s)
    AC020913
    Consensus CDS
    CCDS46011.1
    Related
    ENSP00000263897.4, ENST00000263897.10
    Conserved Domains (1) summary
    pfam09753
    Location:6255
    Use1; Membrane fusion protein Use1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17215346..17219831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026976.1XP_016882465.1  vesicle transport protein USE1 isoform X1

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