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PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha [ Homo sapiens (human) ]

Gene ID: 5576, updated on 23-Nov-2021

Summary

Official Symbol
PRKAR2Aprovided by HGNC
Official Full Name
protein kinase cAMP-dependent type II regulatory subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:9391
See related
Ensembl:ENSG00000114302 MIM:176910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKR2; PRKAR2
Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 11.3), colon (RPKM 10.8) and 25 other tissues See more
Orthologs
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Genomic context

See PRKAR2A in Genome Data Viewer
Location:
3p21.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (48744601..48847874, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48784019..48885307, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 90 Neighboring gene NCK interacting protein with SH3 domain Neighboring gene inositol hexakisphosphate kinase 2 Neighboring gene PRKAR2A antisense RNA 1 Neighboring gene solute carrier family 25 member 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The exposure of CD4+ T cells to HIV gp120 results in a long-lasting hyporesponsiveness to antigen stimulation through protein kinase A-mediated signaling PubMed
env Treatment of normal human fibroblasts with HIV-1 gp120 protein results in a significant decrease in the levels of 8-azido-[32P]cAMP binding to RI and RII domains of protein kinase A (PKA) and in PKA activity PubMed
Nef nef Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells PubMed
Tat tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3606

Gene Ontology Provided by GOA

General protein information

Preferred Names
cAMP-dependent protein kinase type II-alpha regulatory subunit
Names
cAMP-dependent protein kinase regulatory subunit RII alpha
protein kinase A, RII-alpha subunit
protein kinase, cAMP-dependent, regulatory subunit type II alpha
NP_001308911.1
NP_001308912.1
NP_001308918.1
NP_004148.1
XP_005265372.1
XP_011532244.1
XP_011532245.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321982.2NP_001308911.1  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a

    Status: REVIEWED

    Source sequence(s)
    AA774111, AC141002, AC144546, AK026351, AK293042, DB040049
    Consensus CDS
    CCDS2778.1
    UniProtKB/Swiss-Prot
    P13861
    UniProtKB/TrEMBL
    A0A024R2W3, A8KAH7
    Related
    ENSP00000394041.1, ENST00000454963.5
    Conserved Domains (3) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:255371
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:261382
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. NM_001321983.2NP_001308912.1  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform b

    Status: REVIEWED

    Source sequence(s)
    AA774111, AC141002, AC144546, BC002763, DB040049
    Consensus CDS
    CCDS82771.1
    UniProtKB/Swiss-Prot
    P13861
    UniProtKB/TrEMBL
    A0A0S2Z472
    Related
    ENSP00000296446.8, ENST00000296446.12
    Conserved Domains (2) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:139251
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  3. NM_001321989.2NP_001308918.1  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform c

    Status: REVIEWED

    Source sequence(s)
    AC141002, AC144546
    Conserved Domains (3) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:227343
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:233354
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  4. NM_004157.4NP_004148.1  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a

    See identical proteins and their annotated locations for NP_004148.1

    Status: REVIEWED

    Source sequence(s)
    AA774111, AC141002, AC144546, BC002763, CF994284, DB040049, X14968
    Consensus CDS
    CCDS2778.1
    UniProtKB/Swiss-Prot
    P13861
    UniProtKB/TrEMBL
    A0A024R2W3
    Related
    ENSP00000265563.8, ENST00000265563.13
    Conserved Domains (3) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:255371
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:261382
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    48744601..48847874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533942.3XP_011532244.1  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X1

    See identical proteins and their annotated locations for XP_011532244.1

    UniProtKB/Swiss-Prot
    P13861
    UniProtKB/TrEMBL
    A0A024R2W3
    Conserved Domains (3) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:255371
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:261382
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. XM_005265315.4XP_005265372.1  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X3

    Conserved Domains (3) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:135244
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:139251
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  3. XM_011533943.2XP_011532245.1  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X2

    Conserved Domains (3) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:135244
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:139251
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RNA

  1. XR_002959546.1 RNA Sequence

  2. XR_002959547.1 RNA Sequence

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