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Prkar2a protein kinase, cAMP dependent regulatory, type II alpha [ Mus musculus (house mouse) ]

Gene ID: 19087, updated on 1-Mar-2024

Summary

Official Symbol
Prkar2aprovided by MGI
Official Full Name
protein kinase, cAMP dependent regulatory, type II alphaprovided by MGI
Primary source
MGI:MGI:108025
See related
Ensembl:ENSMUSG00000032601 AllianceGenome:MGI:108025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RII(alpha); 1110061A24Rik
Summary
Predicted to enable several functions, including beta-2 adrenergic receptor binding activity; cAMP binding activity; and enzyme binding activity. Involved in modulation of chemical synaptic transmission. Located in cytoplasm and glutamatergic synapse. Part of cAMP-dependent protein kinase complex. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 25.1), large intestine adult (RPKM 25.1) and 28 other tissues See more
Orthologs
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Genomic context

See Prkar2a in Genome Data Viewer
Location:
9 F2; 9 59.63 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108569342..108627643)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108692143..108750444)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ariadne RBR E3 ubiquitin protein ligase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:108551788-108551897 Neighboring gene STARR-seq mESC enhancer starr_25220 Neighboring gene STARR-positive B cell enhancer ABC_E8317 Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene STARR-seq mESC enhancer starr_25223 Neighboring gene STARR-seq mESC enhancer starr_25226 Neighboring gene predicted gene, 24259 Neighboring gene STARR-positive B cell enhancer ABC_E2307 Neighboring gene inositol hexaphosphate kinase 2 Neighboring gene predicted gene, 23034 Neighboring gene NCK interacting protein with SH3 domain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-2 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables cAMP-dependent protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A catalytic subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with axoneme ISO
Inferred from Sequence Orthology
more info
 
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cAMP-dependent protein kinase type II-alpha regulatory subunit
NP_032950.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008924.3NP_032950.1  cAMP-dependent protein kinase type II-alpha regulatory subunit

    See identical proteins and their annotated locations for NP_032950.1

    Status: VALIDATED

    Source sequence(s)
    AC173341, CT571271
    Consensus CDS
    CCDS23536.1
    UniProtKB/Swiss-Prot
    P12367
    UniProtKB/TrEMBL
    Q8K1M3
    Related
    ENSMUSP00000035220.7, ENSMUST00000035220.12
    Conserved Domains (2) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    cd00038
    Location:259380
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108569342..108627643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)