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NAGK N-acetylglucosamine kinase [ Homo sapiens (human) ]

Gene ID: 55577, updated on 31-Dec-2018

Summary

Official Symbol
NAGKprovided by HGNC
Official Full Name
N-acetylglucosamine kinaseprovided by HGNC
Primary source
HGNC:HGNC:17174
See related
Ensembl:ENSG00000124357 MIM:606828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNK; HSA242910
Summary
This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in spleen (RPKM 27.6), esophagus (RPKM 26.3) and 25 other tissues See more
Orthologs

Genomic context

See NAGK in Genome Data Viewer
Location:
2p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (71068278..71078868)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71295408..71305998)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tRNA-Glu (CTC) 15-1 Neighboring gene olfactory receptor family 7 subfamily E member 62 pseudogene Neighboring gene methylmalonyl-CoA epimerase Neighboring gene M-phase phosphoprotein 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
N-acetylglucosamine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
N-acetylglucosamine kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process TAS
Traceable Author Statement
more info
PubMed 
N-acetylmannosamine metabolic process TAS
Traceable Author Statement
more info
PubMed 
N-acetylneuraminate catabolic process IEA
Inferred from Electronic Annotation
more info
 
N-acetylneuraminate catabolic process TAS
Traceable Author Statement
more info
PubMed 
UDP-N-acetylglucosamine biosynthetic process TAS
Traceable Author Statement
more info
 
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
N-acetyl-D-glucosamine kinase
Names
epididymis secretory sperm binding protein
glcNAc kinase
NP_001317354.1
NP_001317355.1
XP_005264470.1
XP_011531259.1
XP_016859929.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330425.2NP_001317354.1  N-acetyl-D-glucosamine kinase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007881
    Consensus CDS
    CCDS82466.1
    UniProtKB/TrEMBL
    C9JEV6
    Related
    ENSP00000396070.3, ENST00000418807.7
    Conserved Domains (1) summary
    cl17037
    Location:2228
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_001330426.1NP_001317355.1  N-acetyl-D-glucosamine kinase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007881
    Consensus CDS
    CCDS82466.1
    UniProtKB/TrEMBL
    C9JEV6
    Conserved Domains (1) summary
    cl17037
    Location:2228
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_001365466.1NP_001352395.1  N-acetyl-D-glucosamine kinase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007881
    Conserved Domains (1) summary
    cl17037
    Location:2228
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. NM_017567.6NP_060037.4  N-acetyl-D-glucosamine kinase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC007881, AK297224, BC001029
    Consensus CDS
    CCDS33220.2
    Related
    ENSP00000477639.1, ENST00000613852.4
    Conserved Domains (1) summary
    cl17037
    Location:1279
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    71068278..71078868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004440.1XP_016859929.1  N-acetyl-D-glucosamine kinase isoform X2

  2. XM_005264413.1XP_005264470.1  N-acetyl-D-glucosamine kinase isoform X1

    UniProtKB/TrEMBL
    C9JEV6
    Conserved Domains (1) summary
    cl17037
    Location:2228
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_011532957.1XP_011531259.1  N-acetyl-D-glucosamine kinase isoform X1

    See identical proteins and their annotated locations for XP_011531259.1

    UniProtKB/TrEMBL
    C9JEV6
    Conserved Domains (1) summary
    cl17037
    Location:2228
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RNA

  1. XR_939694.1 RNA Sequence

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