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ZNF823 zinc finger protein 823 [ Homo sapiens (human) ]

Gene ID: 55552, updated on 9-Jun-2025
Official Symbol
ZNF823provided by HGNC
Official Full Name
zinc finger protein 823provided by HGNC
Primary source
HGNC:HGNC:30936
See related
Ensembl:ENSG00000197933 AllianceGenome:HGNC:30936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSZFP36
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in esophagus (RPKM 2.9), colon (RPKM 2.7) and 25 other tissues See more
Orthologs
all
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See ZNF823 in Genome Data Viewer
Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11721265..11738946, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11849432..11867152, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11832080..11849761, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11785131-11785688 Neighboring gene zinc finger protein 833, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr19.1989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14032 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11849745-11849939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10130 Neighboring gene uncharacterized LOC124904639 Neighboring gene zinc finger protein 441 Neighboring gene MPRA-validated peak3359 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10131 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11908593-11909104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14035 Neighboring gene zinc finger protein 491

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
  2. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
  3. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 823
Names
ZFP 36 for a zinc finger protein
zinc finger protein ZFP-36

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080493.4 → NP_001073962.1  zinc finger protein 823 isoform 1

    See identical proteins and their annotated locations for NP_001073962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC052597, DA519419
    Consensus CDS
    CCDS45981.1
    UniProtKB/Swiss-Prot
    A0PJL4, B7Z8D4, P16415, Q6P4A9
    Related
    ENSP00000340683.5, ENST00000341191.11
    Conserved Domains (5) summary
    smart00349
    Location:4 → 40
    KRAB; krueppel associated box
    COG5048
    Location:109 → 546
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 40
    KRAB; KRAB box
    pfam13465
    Location:513 → 537
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001297610.2 → NP_001284539.1  zinc finger protein 823 isoform 3

    See identical proteins and their annotated locations for NP_001284539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1
    Source sequence(s)
    AK303213, BC052597
    UniProtKB/Swiss-Prot
    P16415
    Conserved Domains (3) summary
    COG5048
    Location:9 → 392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331 → 355
    zf-H2C2_2; Zinc-finger double domain

  3. NM_017507.2 → NP_059977.1  zinc finger protein 823 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK308189, BC052597, DA519419
    UniProtKB/Swiss-Prot
    P16415
    Related
    ENSP00000410654.1, ENST00000431998.1
    Conserved Domains (3) summary
    COG5048
    Location:65 → 502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:457 → 477
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:469 → 493
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11721265..11738946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026942.2 → XP_016882431.1  zinc finger protein 823 isoform X2

    UniProtKB/Swiss-Prot
    P16415
    Conserved Domains (3) summary
    COG5048
    Location:9 → 392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331 → 355
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017026941.2 → XP_016882430.1  zinc finger protein 823 isoform X2

    UniProtKB/Swiss-Prot
    P16415
    Conserved Domains (3) summary
    COG5048
    Location:9 → 392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331 → 355
    zf-H2C2_2; Zinc-finger double domain

  3. XM_024451586.2 → XP_024307354.1  zinc finger protein 823 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:77 → 514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:469 → 489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:510 → 534
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11849432..11867152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321398.1 → XP_054177373.1  zinc finger protein 823 isoform X2

  2. XM_054321397.1 → XP_054177372.1  zinc finger protein 823 isoform X2

  3. XM_054321396.1 → XP_054177371.1  zinc finger protein 823 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16415.2 GenPept UniProtKB/Swiss-Prot:P16415

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