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ZNF823 zinc finger protein 823 [ Homo sapiens (human) ]

Gene ID: 55552, updated on 23-Nov-2021

Summary

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Official Symbol
ZNF823provided by HGNC
Official Full Name
zinc finger protein 823provided by HGNC
Primary source
HGNC:HGNC:30936
See related
Ensembl:ENSG00000197933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSZFP36
Expression
Ubiquitous expression in esophagus (RPKM 2.9), colon (RPKM 2.7) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF823 in Genome Data Viewer
Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11721265..11738997, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11832080..11849761, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 833, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr19.1989 Neighboring gene zinc finger protein 441 Neighboring gene zinc finger protein 491

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
  2. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584,
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781,
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 823
Names
ZFP 36 for a zinc finger protein
zinc finger protein ZFP-36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080493.4 → NP_001073962.1  zinc finger protein 823 isoform 1

    See identical proteins and their annotated locations for NP_001073962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC052597, DA519419
    Consensus CDS
    CCDS45981.1
    UniProtKB/Swiss-Prot
    P16415
    Related
    ENSP00000340683.5, ENST00000341191.11
    Conserved Domains (5) summary
    smart00349
    Location:4 → 40
    KRAB; krueppel associated box
    COG5048
    Location:109 → 546
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501 → 521
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 40
    KRAB; KRAB box
    pfam13465
    Location:513 → 537
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001297610.2 → NP_001284539.1  zinc finger protein 823 isoform 3

    See identical proteins and their annotated locations for NP_001284539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1
    Source sequence(s)
    AK303213, BC052597
    UniProtKB/Swiss-Prot
    P16415
    Conserved Domains (3) summary
    COG5048
    Location:9 → 392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331 → 355
    zf-H2C2_2; Zinc-finger double domain

  3. NM_017507.2 → NP_059977.1  zinc finger protein 823 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK308189, BC052597, DA519419
    UniProtKB/Swiss-Prot
    P16415
    Related
    ENSP00000410654.1, ENST00000431998.1
    Conserved Domains (3) summary
    COG5048
    Location:65 → 502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:457 → 477
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:469 → 493
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    11721265..11738997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026942.1 → XP_016882431.1  zinc finger protein 823 isoform X2

    UniProtKB/Swiss-Prot
    P16415
    Conserved Domains (3) summary
    COG5048
    Location:9 → 392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331 → 355
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017026941.1 → XP_016882430.1  zinc finger protein 823 isoform X2

    UniProtKB/Swiss-Prot
    P16415
    Conserved Domains (3) summary
    COG5048
    Location:9 → 392
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:319 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331 → 355
    zf-H2C2_2; Zinc-finger double domain

  3. XM_024451586.1 → XP_024307354.1  zinc finger protein 823 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:77 → 514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:469 → 489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:510 → 534
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16415.2 GenPept UniProtKB/Swiss-Prot:P16415

Gene LinkOut

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