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PRCC proline rich mitotic checkpoint control factor [ Homo sapiens (human) ]

Gene ID: 5546, updated on 8-Jul-2021

Summary

Official Symbol
PRCCprovided by HGNC
Official Full Name
proline rich mitotic checkpoint control factorprovided by HGNC
Primary source
HGNC:HGNC:9343
See related
Ensembl:ENSG00000143294 MIM:179755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPRC; RCCP1
Summary
This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in brain (RPKM 14.8), spleen (RPKM 14.1) and 25 other tissues See more
Orthologs
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Genomic context

See PRCC in Genome Data Viewer
Location:
1q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156767535..156800815)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156737327..156770607)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene heparin binding growth factor Neighboring gene Sharpr-MPRA regulatory region 3718 Neighboring gene SH2 domain containing 2A Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene insulin receptor related receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of papillary renal cell carcinoma protein (PRCC) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4723, MGC17178

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proline-rich protein PRCC
Names
PRCC, proline rich mitotic checkpoint control factor
papillary renal cell carcinoma (translocation-associated)
papillary renal cell carcinoma translocation-associated gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008138.1 RefSeqGene

    Range
    5054..38334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005973.5NP_005964.3  proline-rich protein PRCC

    See identical proteins and their annotated locations for NP_005964.3

    Status: REVIEWED

    Source sequence(s)
    BC004913, BC010450, BM423590
    Consensus CDS
    CCDS1157.1
    UniProtKB/Swiss-Prot
    Q92733
    UniProtKB/TrEMBL
    A0A0S2Z456, Q96FT4
    Related
    ENSP00000271526.4, ENST00000271526.9
    Conserved Domains (1) summary
    pfam10253
    Location:370491
    PRCC; Mitotic checkpoint regulator, MAD2B-interacting

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156767535..156800815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199416.1: Suppressed sequence

    Description
    NM_199416.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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