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ZNF331 zinc finger protein 331 [ Homo sapiens (human) ]

Gene ID: 55422, updated on 1-Aug-2020

Summary

Official Symbol
ZNF331provided by HGNC
Official Full Name
zinc finger protein 331provided by HGNC
Primary source
HGNC:HGNC:15489
See related
Ensembl:ENSG00000130844 MIM:606043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RITA; ZNF361; ZNF463
Summary
This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]
Expression
Broad expression in adrenal (RPKM 22.0), placenta (RPKM 9.5) and 20 other tissues See more
Orthologs

Genomic context

See ZNF331 in Genome Data Viewer
Location:
19q13.42
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (53503819..53580269)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54024177..54083523)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 813 Neighboring gene tropomyosin 3 pseudogene 6 Neighboring gene ribosomal protein L39 pseudogene 37 Neighboring gene vomeronasal 1 receptor 103 pseudogene Neighboring gene solute carrier family 7 member 3 pseudogene Neighboring gene solute carrier family 7 member 3 pseudogene Neighboring gene divergent-paired related homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686L0787

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 331
Names
C2H2-like zinc finger protein rearranged in thyroid adenomas
KRAB zinc finger protein
zinc finger protein 361
zinc finger protein 463

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_045232.1 RefSeqGene

    Range
    5092..64347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001079906.2NP_001073375.1  zinc finger protein 331

    See identical proteins and their annotated locations for NP_001073375.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as e) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF412402, BF057584, CR749560
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63, Q71QC5
    Related
    ENSP00000393336.2, ENST00000411977.6
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  2. NM_001079907.1NP_001073376.1  zinc finger protein 331

    See identical proteins and their annotated locations for NP_001073376.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as b) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF412401, CR749560
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63, Q71QC6
    Related
    ENSP00000497726.1, ENST00000648397.1
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  3. NM_001253798.2NP_001240727.1  zinc finger protein 331

    See identical proteins and their annotated locations for NP_001240727.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, BQ003434, DA060280
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  4. NM_001253799.2NP_001240728.1  zinc finger protein 331

    See identical proteins and their annotated locations for NP_001240728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as d) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, BQ003434, DA237659
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5
    Related
    ENSP00000496977.1, ENST00000648122.1
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  5. NM_001253800.1NP_001240729.1  zinc finger protein 331

    See identical proteins and their annotated locations for NP_001240729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as ZNF463) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF251515, BQ003434
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5
    Related
    ENSP00000423156.1, ENST00000513999.5
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  6. NM_001253801.2NP_001240730.1  zinc finger protein 331

    See identical proteins and their annotated locations for NP_001240730.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF272148, BQ003434, DB115273
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5
    Related
    ENSP00000421728.1, ENST00000512387.6
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  7. NM_001317113.2NP_001304042.1  zinc finger protein 331

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF251515, AK312889, BF057584, CR749560
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63
    Related
    ENSP00000421014.1, ENST00000511154.5
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  8. NM_001317114.2NP_001304043.1  zinc finger protein 331

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF251515, CR749560, DB173646
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  9. NM_001317115.2NP_001304044.1  zinc finger protein 331

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF251515, BF057584, CR749560, DA160574
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  10. NM_001317116.2NP_001304045.1  zinc finger protein 331

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63
    Related
    ENSP00000497652.1, ENST00000648511.1
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  11. NM_001317117.1NP_001304046.1  zinc finger protein 331

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF251515, CR749560, DB115273, HY038040
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  12. NM_001317118.1NP_001304047.1  zinc finger protein 331

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF251515, CD639405, CR749560, DA150963
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  13. NM_001317119.1NP_001304048.1  zinc finger protein 331

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF251515, AF412401, BP369529, CR749560
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63, Q71QC6
    Related
    ENSP00000425517.2, ENST00000504493.6
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  14. NM_001317120.2NP_001304049.1  zinc finger protein 331

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15, also known as f) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF251515, AF412403, AK128736, CR749560, DA123838
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63, Q71QC4
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  15. NM_001317121.1NP_001304050.1  zinc finger protein 331

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16, also known as a) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC011487, AF251515, AF412400, CR749560
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63, Q71QC5
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  16. NM_018555.6NP_061025.5  zinc finger protein 331

    See identical proteins and their annotated locations for NP_061025.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as g) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AC011487, AK128736, CR749560, DA123838
    Consensus CDS
    CCDS33102.1
    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5, Q68D63
    Related
    ENSP00000253144.9, ENST00000253144.13
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    53503819..53580269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026937.1XP_016882426.1  zinc finger protein 331 isoform X1

    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  2. XM_024451577.1XP_024307345.1  zinc finger protein 331 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  3. XM_024451583.1XP_024307351.1  zinc finger protein 331 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  4. XM_024451582.1XP_024307350.1  zinc finger protein 331 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  5. XM_017026936.1XP_016882425.1  zinc finger protein 331 isoform X1

    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  6. XM_024451584.1XP_024307352.1  zinc finger protein 331 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  7. XM_024451578.1XP_024307346.1  zinc finger protein 331 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  8. XM_024451579.1XP_024307347.1  zinc finger protein 331 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  9. XM_024451580.1XP_024307348.1  zinc finger protein 331 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  10. XM_024451581.1XP_024307349.1  zinc finger protein 331 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  11. XM_011527076.3XP_011525378.1  zinc finger protein 331 isoform X1

    See identical proteins and their annotated locations for XP_011525378.1

    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  12. XM_011527078.3XP_011525380.1  zinc finger protein 331 isoform X1

    See identical proteins and their annotated locations for XP_011525380.1

    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5
    Related
    ENSP00000427439.1, ENST00000511593.6
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  13. XM_017026940.1XP_016882429.1  zinc finger protein 331 isoform X1

    UniProtKB/Swiss-Prot
    Q9NQX6
    UniProtKB/TrEMBL
    A0A024R4J5
    Conserved Domains (3) summary
    COG5048
    Location:185441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
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