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PI4K2A phosphatidylinositol 4-kinase type 2 alpha [ Homo sapiens (human) ]

Gene ID: 55361, updated on 15-Jun-2019

Summary

Official Symbol
PI4K2Aprovided by HGNC
Official Full Name
phosphatidylinositol 4-kinase type 2 alphaprovided by HGNC
Primary source
HGNC:HGNC:30031
See related
Ensembl:ENSG00000155252 MIM:609763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI4KII; PIK42A
Summary
Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in placenta (RPKM 11.9), gall bladder (RPKM 10.1) and 25 other tissues See more
Orthologs

Genomic context

See PI4K2A in Genome Data Viewer
Location:
10q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (97640686..97676434)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99400443..99436187)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene chromosome 10 open reading frame 62 Neighboring gene 4-hydroxy-2-oxoglutarate aldolase 1 Neighboring gene MORN repeat containing 4 Neighboring gene arginine vasopressin induced 1 Neighboring gene MARVEL domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Rab27a is required for plasma membrane delivery of PI4K2A and HIV-1 Gag assembly in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761G1923

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
AP-3 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with BLOC-1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
growing cell tip ISS
Inferred from Sequence or Structural Similarity
more info
 
host cell presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane HDA PubMed 
membrane HDA PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol 4-kinase type 2-alpha
Names
phosphatidylinositol 4-kinase type II (PI4KII)
phosphatidylinositol 4-kinase type II-alpha
NP_060895.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018425.3NP_060895.1  phosphatidylinositol 4-kinase type 2-alpha

    See identical proteins and their annotated locations for NP_060895.1

    Status: VALIDATED

    Source sequence(s)
    AF070611, AJ303098, BC003167
    Consensus CDS
    CCDS7469.1
    UniProtKB/Swiss-Prot
    Q9BTU6
    Related
    ENSP00000359665.3, ENST00000370631.3
    Conserved Domains (1) summary
    pfam00454
    Location:133429
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    97640686..97676434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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