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PPP3R2 protein phosphatase 3 regulatory subunit B, beta [ Homo sapiens (human) ]

Gene ID: 5535, updated on 23-Nov-2021

Summary

Official Symbol
PPP3R2provided by HGNC
Official Full Name
protein phosphatase 3 regulatory subunit B, betaprovided by HGNC
Primary source
HGNC:HGNC:9318
See related
Ensembl:ENSG00000188386 MIM:613821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP3RL
Orthologs
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Genomic context

See PPP3R2 in Genome Data Viewer
Location:
9q31.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (101591604..101594969, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (104353886..104357251, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene TMEM246 antisense RNA 1 Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 Neighboring gene ring finger protein 20 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3A Neighboring gene uncharacterized LOC105376186 Neighboring gene Sharpr-MPRA regulatory region 1857

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein serine/threonine phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcineurin subunit B type 2
Names
CBLP
CNBII
calcineurin B, type II (19kDa)
calcineurin B-like protein
calcineurin BII
protein phosphatase 2B regulatory subunit 2
NP_671709.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147180.4NP_671709.2  calcineurin subunit B type 2

    Status: VALIDATED

    Source sequence(s)
    AA904764, AL591377, BC030595
    Consensus CDS
    CCDS6759.1
    Related
    ENSP00000363939.2, ENST00000374806.2
    Conserved Domains (1) summary
    COG5126
    Location:13159
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    101591604..101594969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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