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PPP3R2 protein phosphatase 3 regulatory subunit B, beta [ Homo sapiens (human) ]

Gene ID: 5535, updated on 26-Oct-2022

Summary

Official Symbol
PPP3R2provided by HGNC
Official Full Name
protein phosphatase 3 regulatory subunit B, betaprovided by HGNC
Primary source
HGNC:HGNC:9318
See related
Ensembl:ENSG00000188386 MIM:613821; AllianceGenome:HGNC:9318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP3RL
Summary
Predicted to enable calcium ion binding activity and calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within penetration of zona pellucida. Predicted to be located in sperm mitochondrial sheath. Predicted to be part of calcineurin complex. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See PPP3R2 in Genome Data Viewer
Location:
9q31.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (101591604..101594969, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (113766356..113769721, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (104353886..104357251, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene TMEM246 antisense RNA 1 Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 Neighboring gene ring finger protein 20 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3A Neighboring gene uncharacterized LOC105376186 Neighboring gene Sharpr-MPRA regulatory region 1857

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent protein serine/threonine phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of calcineurin complex IC
Inferred by Curator
more info
PubMed 
located_in cytosol IC
Inferred by Curator
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
part_of protein serine/threonine phosphatase complex IC
Inferred by Curator
more info
PubMed 
located_in sperm mitochondrial sheath IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcineurin subunit B type 2
Names
CBLP
CNBII
calcineurin B, type II (19kDa)
calcineurin B-like protein
calcineurin BII
protein phosphatase 2B regulatory subunit 2
NP_671709.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147180.4NP_671709.2  calcineurin subunit B type 2

    Status: VALIDATED

    Source sequence(s)
    AA904764, AL591377, BC030595
    Consensus CDS
    CCDS6759.2
    UniProtKB/Swiss-Prot
    Q8WYJ4
    Related
    ENSP00000363939.2, ENST00000374806.2
    Conserved Domains (1) summary
    COG5126
    Location:13159
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    101591604..101594969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    113766356..113769721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)