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Ppp3r2 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [ Mus musculus (house mouse) ]

Gene ID: 19059, updated on 18-Sep-2024

Summary

Official Symbol
Ppp3r2provided by MGI
Official Full Name
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)provided by MGI
Primary source
MGI:MGI:107171
See related
Ensembl:ENSMUSG00000028310 AllianceGenome:MGI:107171
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CnB2; CaNB2
Summary
Predicted to enable calcium-dependent protein serine/threonine phosphatase activity. Predicted to act upstream of or within defense response; glycogen metabolic process; and sperm displacement. Is expressed in brain; heart; lung; male reproductive gland or organ; and renal vasculature. Orthologous to human PPP3R2 (protein phosphatase 3 regulatory subunit B, beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 63.5) See more
Orthologs
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Genomic context

See Ppp3r2 in Genome Data Viewer
Location:
4 B1; 4 26.75 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49678747..49681983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49678747..49681983, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2112 Neighboring gene predicted gene, 45952 Neighboring gene ring finger protein 20 Neighboring gene glutamate receptor ionotropic, NMDA3A Neighboring gene STARR-seq mESC enhancer starr_10189 Neighboring gene STARR-seq mESC enhancer starr_10190 Neighboring gene predicted gene, 25485 Neighboring gene STARR-seq mESC enhancer starr_10191 Neighboring gene STARR-seq mESC enhancer starr_10192 Neighboring gene STARR-seq mESC enhancer starr_10193 Neighboring gene STARR-seq mESC enhancer starr_10194 Neighboring gene predicted gene, 42288 Neighboring gene predicted gene, 42287

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of calcineurin complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of calcineurin complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
part_of protein serine/threonine phosphatase complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm mitochondrial sheath IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcineurin subunit B type 2
Names
PP2B beta 2
calcineurin B subunit
protein phosphatase 2B regulatory subunit 2
NP_001004025.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004025.4NP_001004025.1  calcineurin subunit B type 2

    See identical proteins and their annotated locations for NP_001004025.1

    Status: PROVISIONAL

    Source sequence(s)
    AL732521
    Consensus CDS
    CCDS18179.1
    UniProtKB/Swiss-Prot
    Q63811
    UniProtKB/TrEMBL
    Q497S1
    Related
    ENSMUSP00000029991.3, ENSMUST00000029991.3
    Conserved Domains (2) summary
    PTZ00184
    Location:17153
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:91158
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    49678747..49681983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)