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PPP3R1 protein phosphatase 3 regulatory subunit B, alpha [ Homo sapiens (human) ]

Gene ID: 5534, updated on 27-Nov-2024

Summary

Official Symbol
PPP3R1provided by HGNC
Official Full Name
protein phosphatase 3 regulatory subunit B, alphaprovided by HGNC
Primary source
HGNC:HGNC:9317
See related
Ensembl:ENSG00000221823 MIM:601302; AllianceGenome:HGNC:9317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNB; CNB1; CALNB1
Summary
Enables phosphatase binding activity and protein domain specific binding activity. Involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Part of calcineurin complex. Implicated in Alzheimer's disease and dilated cardiomyopathy. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 81.4), fat (RPKM 34.1) and 24 other tissues See more
Orthologs
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Genomic context

See PPP3R1 in Genome Data Viewer
Location:
2p14
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (68178857..68252532, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (68189412..68263096, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68405989..68479664, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 10 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:68383902-68384834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59016 Neighboring gene partner of NOB1 homolog Neighboring gene VISTA enhancer hs2040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:68432700-68433200 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59162 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59182 Neighboring gene uncharacterized LOC107985892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:68480114-68480783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11589 Neighboring gene cannabinoid receptor interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 10638 Neighboring gene uncharacterized LOC102724389

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat HIV-1 Tat 47-59 peptide upregulates gene expression of protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (PPP3R1) in U-937 macrophages PubMed
tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium-dependent protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in lung epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of calcium ion import across plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of calcineurin-NFAT signaling cascade NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of calcium ion import across plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of calcineurin complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
part_of protein serine/threonine phosphatase complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcineurin subunit B type 1
Names
calcineurin B, type I (19kDa)
protein phosphatase 2B regulatory subunit 1
protein phosphatase 2B regulatory subunit B alpha
NP_000936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000945.4NP_000936.1  calcineurin subunit B type 1

    See identical proteins and their annotated locations for NP_000936.1

    Status: VALIDATED

    Source sequence(s)
    AC017083, BC027913, BM468705, BQ228635
    Consensus CDS
    CCDS46310.1
    UniProtKB/Swiss-Prot
    B2RC10, B5MDU4, P06705, P15117, P63098, Q08044, Q53SL0
    Related
    ENSP00000234310.3, ENST00000234310.8
    Conserved Domains (1) summary
    COG5126
    Location:13157
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    68178857..68252532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    68189412..68263096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)