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PPP3R1 protein phosphatase 3 regulatory subunit B, alpha [ Homo sapiens (human) ]

Gene ID: 5534, updated on 1-Aug-2020

Summary

Official Symbol
PPP3R1provided by HGNC
Official Full Name
protein phosphatase 3 regulatory subunit B, alphaprovided by HGNC
Primary source
HGNC:HGNC:9317
See related
Ensembl:ENSG00000221823 MIM:601302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNB; CNB1; CALNB1
Expression
Ubiquitous expression in brain (RPKM 81.4), fat (RPKM 34.1) and 24 other tissues See more
Orthologs

Genomic context

See PPP3R1 in Genome Data Viewer
Location:
2p14
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (68178857..68252532, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68405979..68483392, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 92 Neighboring gene partner of NOB1 homolog Neighboring gene VISTA enhancer hs2040 Neighboring gene uncharacterized LOC107985892 Neighboring gene cannabinoid receptor interacting protein 1 Neighboring gene uncharacterized LOC102724389

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat HIV-1 Tat 47-59 peptide upregulates gene expression of protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (PPP3R1) in U-937 macrophages PubMed
tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: WDR92

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
calcium-dependent protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
calcineurin complex IDA
Inferred from Direct Assay
more info
PubMed 
calcineurin complex NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcineurin subunit B type 1
Names
calcineurin B, type I (19kDa)
protein phosphatase 2B regulatory subunit 1
protein phosphatase 2B regulatory subunit B alpha
protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)
protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
NP_000936.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000945.4NP_000936.1  calcineurin subunit B type 1

    See identical proteins and their annotated locations for NP_000936.1

    Status: VALIDATED

    Source sequence(s)
    AC017083, BC027913, BM468705, BQ228635
    Consensus CDS
    CCDS46310.1
    UniProtKB/Swiss-Prot
    P63098
    Related
    ENSP00000234310.3, ENST00000234310.8
    Conserved Domains (1) summary
    COG5126
    Location:13157
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    68178857..68252532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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