Format

Send to:

Choose Destination

PPP3R1 protein phosphatase 3 regulatory subunit B, alpha [ Homo sapiens (human) ]

Gene ID: 5534, updated on 6-May-2021

Summary

Official Symbol
PPP3R1provided by HGNC
Official Full Name
protein phosphatase 3 regulatory subunit B, alphaprovided by HGNC
Primary source
HGNC:HGNC:9317
See related
Ensembl:ENSG00000221823 MIM:601302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNB; CNB1; CALNB1
Expression
Ubiquitous expression in brain (RPKM 81.4), fat (RPKM 34.1) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PPP3R1 in Genome Data Viewer
Location:
2p14
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (68178857..68252532, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68405989..68479664, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 10 Neighboring gene partner of NOB1 homolog Neighboring gene VISTA enhancer hs2040 Neighboring gene uncharacterized LOC107985892 Neighboring gene cannabinoid receptor interacting protein 1 Neighboring gene uncharacterized LOC102724389

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat HIV-1 Tat 47-59 peptide upregulates gene expression of protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (PPP3R1) in U-937 macrophages PubMed
tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium-dependent protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium-dependent protein serine/threonine phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
involved_in branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in lung epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of calcineurin complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcineurin subunit B type 1
Names
calcineurin B, type I (19kDa)
protein phosphatase 2B regulatory subunit 1
protein phosphatase 2B regulatory subunit B alpha
NP_000936.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000945.4NP_000936.1  calcineurin subunit B type 1

    See identical proteins and their annotated locations for NP_000936.1

    Status: VALIDATED

    Source sequence(s)
    AC017083, BC027913, BM468705, BQ228635
    Consensus CDS
    CCDS46310.1
    UniProtKB/Swiss-Prot
    P63098
    Related
    ENSP00000234310.3, ENST00000234310.8
    Conserved Domains (1) summary
    COG5126
    Location:13157
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    68178857..68252532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center