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PPP3CA protein phosphatase 3 catalytic subunit alpha [ Homo sapiens (human) ]

Gene ID: 5530, updated on 28-May-2022

Summary

Official Symbol
PPP3CAprovided by HGNC
Official Full Name
protein phosphatase 3 catalytic subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:9314
See related
Ensembl:ENSG00000138814 MIM:114105; AllianceGenome:HGNC:9314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CALN; CCN1; CNA1; CALNA; DEE91; IECEE; PPP2B; ACCIID; CALNA1; IECEE1
Summary
Enables several functions, including ATPase binding activity; calmodulin binding activity; and calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; peptidyl-serine dephosphorylation; and response to calcium ion. Located in several cellular components, including cytosol; dendritic spine; and nucleoplasm. Part of calcineurin complex. Colocalizes with cytoplasmic side of plasma membrane. Implicated in developmental and epileptic encephalopathy 91. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 54.0), prostate (RPKM 42.7) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PPP3CA in Genome Data Viewer
Location:
4q24
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (101023418..101347526, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (104338695..104662217, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (101944575..102268683, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1216 Neighboring gene long intergenic non-protein coding RNA 1217 Neighboring gene Sharpr-MPRA regulatory region 8198 Neighboring gene Sharpr-MPRA regulatory region 422 Neighboring gene Sharpr-MPRA regulatory region 14793 Neighboring gene microRNA 8066 Neighboring gene microRNA 1255a Neighboring gene uncharacterized LOC90024 Neighboring gene uncharacterized LOC124900741

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries.
EBI GWAS Catalog
A genome-wide association study of anorexia nervosa.
EBI GWAS Catalog
Genome-wide linkage and association scans for pulse pressure in Chinese twins.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcineurin-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in epidermis development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in modulation of chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in multicellular organismal response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of calcium ion import across plasma membrane IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of chromatin binding IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of miRNA maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of voltage-gated calcium channel activity IC
Inferred by Curator
more info
PubMed 
involved_in peptidyl-serine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of activated T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of calcineurin-NFAT signaling cascade IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of calcium ion import across plasma membrane IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of connective tissue replacement IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glomerulus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of saliva secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of voltage-gated calcium channel activity IC
Inferred by Curator
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell proliferation involved in kidney morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in renal filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in skeletal muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in skeletal muscle tissue regeneration TAS
Traceable Author Statement
more info
PubMed 
involved_in transition between fast and slow fiber IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of calcineurin complex IC
Inferred by Curator
more info
PubMed 
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of calcineurin complex NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IC
Inferred by Curator
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein serine/threonine phosphatase complex IC
Inferred by Curator
more info
PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
located_in slit diaphragm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 3 catalytic subunit alpha
Names
CAM-PRP catalytic subunit
CNA alpha
calcineurin A alpha
protein phosphatase 3 catalytic subunit alpha isozyme
NP_000935.1
NP_001124163.1
NP_001124164.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000944.5NP_000935.1  protein phosphatase 3 catalytic subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_000935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL353950, AP001816, AP001870, AW973358, EU192652
    Consensus CDS
    CCDS34037.1
    UniProtKB/Swiss-Prot
    Q08209
    UniProtKB/TrEMBL
    A0A0S2Z4C6
    Related
    ENSP00000378323.3, ENST00000394854.8
    Conserved Domains (1) summary
    cd07416
    Location:41345
    MPP_PP2B; PP2B, metallophosphatase domain
  2. NM_001130691.2NP_001124163.1  protein phosphatase 3 catalytic subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_001124163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AP001816, AP001870, AW973358, BC025714, EU192652
    Consensus CDS
    CCDS47114.1
    UniProtKB/Swiss-Prot
    Q08209
    UniProtKB/TrEMBL
    A0A0S2Z4B5
    Related
    ENSP00000378322.4, ENST00000394853.8
    Conserved Domains (1) summary
    cd07416
    Location:41345
    MPP_PP2B; PP2B, metallophosphatase domain
  3. NM_001130692.2NP_001124164.1  protein phosphatase 3 catalytic subunit alpha isoform 3

    See identical proteins and their annotated locations for NP_001124164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple in-frame exons in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AP001816, AP001870, AW973358, EU192652
    Consensus CDS
    CCDS47113.1
    UniProtKB/Swiss-Prot
    Q08209
    Related
    ENSP00000320580.6, ENST00000323055.10
    Conserved Domains (1) summary
    cd07416
    Location:41329
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    101023418..101347526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    104338695..104662217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)