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PPP3CA protein phosphatase 3 catalytic subunit alpha [ Homo sapiens (human) ]

Gene ID: 5530, updated on 9-Aug-2020

Summary

Official Symbol
PPP3CAprovided by HGNC
Official Full Name
protein phosphatase 3 catalytic subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:9314
See related
Ensembl:ENSG00000138814 MIM:114105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CALN; CCN1; CNA1; CALNA; IECEE; PPP2B; ACCIID; CALNA1; IECEE1
Expression
Broad expression in brain (RPKM 54.0), prostate (RPKM 42.7) and 24 other tissues See more
Orthologs

Genomic context

See PPP3CA in Genome Data Viewer
Location:
4q24
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (101023418..101348295, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (101944587..102268655, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1216 Neighboring gene long intergenic non-protein coding RNA 1218 Neighboring gene microRNA 8066 Neighboring gene microRNA 1255a Neighboring gene uncharacterized LOC90024 Neighboring gene uncharacterized LOC107986297 Neighboring gene RNA, U6 small nuclear 462, pseudogene Neighboring gene B cell scaffold protein with ankyrin repeats 1 Neighboring gene MT-ND5 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
ARTHROGRYPOSIS, CLEFT PALATE, CRANIOSYNOSTOSIS, AND IMPAIRED INTELLECTUAL DEVELOPMENT
MedGen: C4748872 OMIM: 618265 GeneReviews: Not available
not available
Epileptic encephalopathy, infantile or early childhood 1
MedGen: C4540199 OMIM: 617711 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries.
NHGRI GWA Catalog
A genome-wide association study of anorexia nervosa.
NHGRI GWA Catalog
Genome-wide linkage and association scans for pulse pressure in Chinese twins.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin-dependent protein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
T cell activation TAS
Traceable Author Statement
more info
PubMed 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal response to stress IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chromatin binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of connective tissue replacement IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue regeneration TAS
Traceable Author Statement
more info
PubMed 
transition between fast and slow fiber IEA
Inferred from Electronic Annotation
more info
 
wound healing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
Z disc IEA
Inferred from Electronic Annotation
more info
 
calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcineurin complex IDA
Inferred from Direct Assay
more info
PubMed 
calcineurin complex NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of plasma membrane IC
Inferred by Curator
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
slit diaphragm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Names
CAM-PRP catalytic subunit
calcineurin A alpha
calmodulin-dependent calcineurin A subunit alpha isoform
protein phosphatase 2B, catalytic subunit, alpha isoform
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
protein phosphatase 3 catalytic subunit alpha isozyme
NP_000935.1
NP_001124163.1
NP_001124164.1
XP_016863854.1
XP_024309895.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000944.5NP_000935.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 1

    See identical proteins and their annotated locations for NP_000935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL353950, AP001816, AP001870, AW973358, EU192652
    Consensus CDS
    CCDS34037.1
    UniProtKB/Swiss-Prot
    Q08209
    UniProtKB/TrEMBL
    A0A0S2Z4C6
    Related
    ENSP00000378323.3, ENST00000394854.8
    Conserved Domains (1) summary
    cd07416
    Location:41345
    MPP_PP2B; PP2B, metallophosphatase domain
  2. NM_001130691.2NP_001124163.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 2

    See identical proteins and their annotated locations for NP_001124163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AP001816, AP001870, AW973358, BC025714, EU192652
    Consensus CDS
    CCDS47114.1
    UniProtKB/Swiss-Prot
    Q08209
    UniProtKB/TrEMBL
    A0A0S2Z4B5
    Related
    ENSP00000378322.4, ENST00000394853.8
    Conserved Domains (1) summary
    cd07416
    Location:41345
    MPP_PP2B; PP2B, metallophosphatase domain
  3. NM_001130692.2NP_001124164.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 3

    See identical proteins and their annotated locations for NP_001124164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple in-frame exons in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AP001816, AP001870, AW973358, EU192652
    Consensus CDS
    CCDS47113.1
    UniProtKB/Swiss-Prot
    Q08209
    Related
    ENSP00000320580.6, ENST00000323055.10
    Conserved Domains (1) summary
    cd07416
    Location:41329
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    101023418..101348295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454127.1XP_024309895.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2

    Related
    ENSP00000422990.1, ENST00000507176.5
    Conserved Domains (1) summary
    cd07416
    Location:1295
    MPP_PP2B; PP2B, metallophosphatase domain
  2. XM_017008365.1XP_016863854.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1

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