Format

Send to:

Choose Destination

PPP2R5C protein phosphatase 2 regulatory subunit B'gamma [ Homo sapiens (human) ]

Gene ID: 5527, updated on 5-Sep-2020

Summary

Official Symbol
PPP2R5Cprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit B'gammaprovided by HGNC
Primary source
HGNC:HGNC:9311
See related
Ensembl:ENSG00000078304 MIM:601645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B56G; PR61G; B56gamma
Summary
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 21.8), testis (RPKM 19.2) and 25 other tissues See more
Orthologs

Genomic context

See PPP2R5C in Genome Data Viewer
Location:
14q32.31
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (101760573..101927992)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102226910..102394329)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2320 Neighboring gene ribosomal protein L26 pseudogene 4 Neighboring gene long intergenic non-protein coding RNA 239 Neighboring gene uncharacterized LOC107984658 Neighboring gene RNA, U6 small nuclear 790, pseudogene Neighboring gene uncharacterized LOC107984659 Neighboring gene nucleophosmin 1 pseudogene 20 Neighboring gene dynein cytoplasmic 1 heavy chain 1 Neighboring gene uncharacterized LOC107984661 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide scan for common alleles affecting risk for autism.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23064

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Names
B' alpha regulatory subunit
protein phosphatase 2 regulatory subunit B', gamma
renal carcinoma antigen NY-REN-29

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047069.1 RefSeqGene

    Range
    6226..172420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161725.2NP_001155197.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AA487513, AI282996, AI692258, AK131391, AK302470, AL137779
    Consensus CDS
    CCDS53912.1
    UniProtKB/Swiss-Prot
    Q13362
    Related
    ENSP00000412324.2, ENST00000422945.6
    Conserved Domains (2) summary
    PLN00122
    Location:373473
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:65468
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  2. NM_001161726.2NP_001155198.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform f

    See identical proteins and their annotated locations for NP_001155198.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (f) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AA487513, AI282996, AI692258, AK131391, AL137779
    Consensus CDS
    CCDS53911.1
    UniProtKB/Swiss-Prot
    Q13362
    Related
    ENSP00000329009.5, ENST00000328724.9
    Conserved Domains (1) summary
    pfam01603
    Location:87492
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  3. NM_001352912.1NP_001339841.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    Consensus CDS
    CCDS9965.1
    Conserved Domains (1) summary
    pfam01603
    Location:32437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  4. NM_001352913.2NP_001339842.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform g

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    Conserved Domains (1) summary
    pfam01603
    Location:87492
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  5. NM_001352914.2NP_001339843.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform h

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    Conserved Domains (1) summary
    pfam01603
    Location:92497
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  6. NM_001352915.2NP_001339844.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform j

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    Conserved Domains (1) summary
    pfam01603
    Location:1362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  7. NM_001352916.2NP_001339845.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform i

    Status: REVIEWED

    Source sequence(s)
    AL118558, AL137779
    Conserved Domains (1) summary
    pfam01603
    Location:1362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  8. NM_002719.4NP_002710.2  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a

    See identical proteins and their annotated locations for NP_002710.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (a), also known as B' alpha 1 and gamma 3.
    Source sequence(s)
    AA487513, AI282996, AK131391, DA853338, U37352
    Consensus CDS
    CCDS9964.1
    UniProtKB/Swiss-Prot
    Q13362
    Related
    ENSP00000333905.4, ENST00000334743.9
    Conserved Domains (2) summary
    PLN00122
    Location:342442
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:34437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  9. NM_178586.3NP_848701.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b

    See identical proteins and their annotated locations for NP_848701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), also known as gamma 2.
    Source sequence(s)
    AA487513, AI282996, AK131391, D26445, DA853338
    Consensus CDS
    CCDS9965.1
    UniProtKB/Swiss-Prot
    Q13362
    Related
    ENSP00000262239.5, ENST00000350249.7
    Conserved Domains (1) summary
    pfam01603
    Location:32437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  10. NM_178587.3NP_848702.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform c

    See identical proteins and their annotated locations for NP_848702.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and the 3' coding region, compared to variant 1. It encodes an isoform (c), also known as gamma 1, that is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA716736, DA853338, L42375
    Consensus CDS
    CCDS45163.1
    UniProtKB/Swiss-Prot
    Q13362
    Related
    ENSP00000408389.3, ENST00000445439.7
    Conserved Domains (2) summary
    PLN00122
    Location:342443
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:34437
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    101760573..101927992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267827.1XP_005267884.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7

    See identical proteins and their annotated locations for XP_005267884.1

    UniProtKB/Swiss-Prot
    Q13362
    Conserved Domains (1) summary
    pfam01603
    Location:1362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  2. XM_005267819.1XP_005267876.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_005267876.1

    Conserved Domains (2) summary
    PLN00122
    Location:402502
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:94497
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  3. XM_005267824.1XP_005267881.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

    Conserved Domains (2) summary
    PLN00122
    Location:402486
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:94481
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  4. XM_005267822.3XP_005267879.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

    See identical proteins and their annotated locations for XP_005267879.1

    Conserved Domains (2) summary
    PLN00122
    Location:402502
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:94497
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  5. XM_017021423.2XP_016876912.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6

  6. XM_011536920.1XP_011535222.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7

    See identical proteins and their annotated locations for XP_011535222.1

    UniProtKB/Swiss-Prot
    Q13362
    Conserved Domains (1) summary
    pfam01603
    Location:1362
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  7. XM_011536918.1XP_011535220.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

    See identical proteins and their annotated locations for XP_011535220.1

    Conserved Domains (2) summary
    PLN00122
    Location:326426
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:18421
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  8. XM_005267826.1XP_005267883.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

    Conserved Domains (2) summary
    PLN00122
    Location:318418
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:10413
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178588.1: Suppressed sequence

    Description
    NM_178588.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center