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NEIL3 nei like DNA glycosylase 3 [ Homo sapiens (human) ]

Gene ID: 55247, updated on 11-Sep-2019

Summary

Official Symbol
NEIL3provided by HGNC
Official Full Name
nei like DNA glycosylase 3provided by HGNC
Primary source
HGNC:HGNC:24573
See related
Ensembl:ENSG00000109674 MIM:608934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3
Summary
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in bone marrow (RPKM 2.5), lymph node (RPKM 1.9) and 13 other tissues See more
Orthologs

Genomic context

See NEIL3 in Genome Data Viewer
Location:
4q34.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (177309871..177362936)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (178230991..178284092)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 136 Neighboring gene uncharacterized LOC105377557 Neighboring gene uncharacterized LOC105377558 Neighboring gene Sharpr-MPRA regulatory region 1546 Neighboring gene uncharacterized LOC285500 Neighboring gene aspartylglucosaminidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nei endonuclease VIII-like 3 (NEIL3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Base excision repair, organism-specific biosystem (from KEGG)
    Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • Base excision repair, conserved biosystem (from KEGG)
    Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10858

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA N-glycosylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
bubble DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
base-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
base-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endonuclease 8-like 3
Names
DNA glycosylase FPG2
DNA glycosylase hFPG2
DNA glycosylase/AP lyase Neil3
endonuclease VIII-like 3
nei endonuclease VIII-like 3
nei-like protein 3
zinc finger, GRF-type containing 3
NP_060718.3
XP_016863849.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018248.3NP_060718.3  endonuclease 8-like 3

    Status: VALIDATED

    Source sequence(s)
    AC027627
    Consensus CDS
    CCDS3828.1
    Related
    ENSP00000264596.3, ENST00000264596.4
    Conserved Domains (5) summary
    cd08969
    Location:1151
    MeNeil3_N; N-terminal domain of metazoan Nei-like glycosylase 3 (NEIL3)
    sd00029
    Location:321340
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:317345
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam06839
    Location:552596
    zf-GRF; GRF zinc finger
    cl26942
    Location:61281
    H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    177309871..177362936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008360.1XP_016863849.1  endonuclease 8-like 3 isoform X1

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