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RIC8B RIC8 guanine nucleotide exchange factor B [ Homo sapiens (human) ]

Gene ID: 55188, updated on 24-Nov-2020

Summary

Official Symbol
RIC8Bprovided by HGNC
Official Full Name
RIC8 guanine nucleotide exchange factor Bprovided by HGNC
Primary source
HGNC:HGNC:25555
See related
Ensembl:ENSG00000111785 MIM:609147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIC8; hSyn
Expression
Ubiquitous expression in thyroid (RPKM 2.6), gall bladder (RPKM 2.0) and 25 other tissues See more
Orthologs

Genomic context

See RIC8B in Genome Data Viewer
Location:
12q23.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (106774621..106889316)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (107168077..107283094)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit B Neighboring gene uncharacterized LOC100287944 Neighboring gene regulatory factor X4 Neighboring gene uncharacterized LOC100505978 Neighboring gene uncharacterized LOC105369961 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 4 Neighboring gene ribosomal protein L30 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of autistic-like traits in a general population study of young adults.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of resistance to inhibitors of cholinesterase 8 homolog B (C. elegans, RIC8B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10620, MGC39476

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
synembryn-B
Names
brain synembrin
brain synembryn
resistance to inhibitors of cholinesterase 8 homolog B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330145.2NP_001317074.1  synembryn-B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC007695, AW896637, BC034220, BX105894, DA325821
    Consensus CDS
    CCDS81734.1
    UniProtKB/Swiss-Prot
    Q9NVN3
    UniProtKB/TrEMBL
    B7WPL0
    Related
    ENSP00000376582.4, ENST00000392837.9
    Conserved Domains (1) summary
    pfam10165
    Location:66537
    Ric8; Guanine nucleotide exchange factor synembryn
  2. NM_001330146.2NP_001317075.1  synembryn-B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC007695, AW896637, BC034220, BX105894, DA325821
    UniProtKB/Swiss-Prot
    Q9NVN3
    Conserved Domains (1) summary
    pfam10165
    Location:50521
    Ric8; Guanine nucleotide exchange factor synembryn
  3. NM_001330147.2NP_001317076.1  synembryn-B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC007695, BC034220, BX105894, DA325821
    Consensus CDS
    CCDS81733.1
    UniProtKB/Swiss-Prot
    Q9NVN3
    UniProtKB/TrEMBL
    A0A024RBG9
    Related
    ENSP00000435301.1, ENST00000462949.5
    Conserved Domains (1) summary
    pfam10165
    Location:66524
    Ric8; Guanine nucleotide exchange factor synembryn
  4. NM_001351361.2NP_001338290.1  synembryn-B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
    Conserved Domains (1) summary
    pfam10165
    Location:58529
    Ric8; Guanine nucleotide exchange factor synembryn
  5. NM_001351362.2NP_001338291.1  synembryn-B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
    Conserved Domains (1) summary
    pfam10165
    Location:58476
    Ric8; Guanine nucleotide exchange factor synembryn
  6. NM_001351363.2NP_001338292.1  synembryn-B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
    Conserved Domains (1) summary
    pfam10165
    Location:50468
    Ric8; Guanine nucleotide exchange factor synembryn
  7. NM_001351364.2NP_001338293.1  synembryn-B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC007695, BC034220
    Consensus CDS
    CCDS86331.1
    Related
    ENSP00000347662.2, ENST00000355478.6
    Conserved Domains (1) summary
    pfam10165
    Location:26484
    Ric8; Guanine nucleotide exchange factor synembryn
  8. NM_001351366.2NP_001338295.1  synembryn-B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
    Conserved Domains (1) summary
    pfam10165
    Location:1449
    Ric8; Guanine nucleotide exchange factor synembryn
  9. NM_001351367.2NP_001338296.1  synembryn-B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
    Conserved Domains (1) summary
    pfam10165
    Location:1396
    Ric8; Guanine nucleotide exchange factor synembryn
  10. NM_018157.4NP_060627.2  synembryn-B isoform 4

    See identical proteins and their annotated locations for NP_060627.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) shorter than isoform 1.
    Source sequence(s)
    AC007695, BX105894, CB215722, DA014333, DA118965, DA534432
    Consensus CDS
    CCDS9109.2
    UniProtKB/Swiss-Prot
    Q9NVN3
    Related
    ENSP00000376583.2, ENST00000392839.6
    Conserved Domains (1) summary
    pfam10165
    Location:66483
    Ric8; Guanine nucleotide exchange factor synembryn

RNA

  1. NR_147131.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
  2. NR_147132.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
  3. NR_147133.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
  4. NR_147134.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
  5. NR_147135.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
  6. NR_147136.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
  7. NR_147137.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
  8. NR_147138.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011
  9. NR_147139.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007695, AC079385, AC090011

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    106774621..106889316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001748786.2 RNA Sequence

  2. XR_001748785.2 RNA Sequence

  3. XR_002957347.1 RNA Sequence

  4. XR_002957348.1 RNA Sequence

  5. XR_002957345.1 RNA Sequence

  6. XR_002957346.1 RNA Sequence

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