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Ric8b RIC8 guanine nucleotide exchange factor B [ Mus musculus (house mouse) ]

Gene ID: 237422, updated on 12-May-2024

Summary

Official Symbol
Ric8bprovided by MGI
Official Full Name
RIC8 guanine nucleotide exchange factor Bprovided by MGI
Primary source
MGI:MGI:2682307
See related
Ensembl:ENSMUSG00000035620 AllianceGenome:MGI:2682307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ric-8; Ric-8b
Summary
Predicted to enable G-protein alpha-subunit binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human RIC8B (RIC8 guanine nucleotide exchange factor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 7.7), CNS E18 (RPKM 7.5) and 28 other tissues See more
Orthologs
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Genomic context

See Ric8b in Genome Data Viewer
Location:
10 C1; 10 41.63 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84753136..84854201)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (84917268..85018337)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene regulatory factor X, 4 (influences HLA class II expression) Neighboring gene STARR-positive B cell enhancer ABC_E6894 Neighboring gene predicted gene, 53596 Neighboring gene predicted gene, 40728 Neighboring gene STARR-seq mESC enhancer starr_27430 Neighboring gene STARR-seq mESC enhancer starr_27432 Neighboring gene STARR-positive B cell enhancer ABC_E2956 Neighboring gene predicted gene, 34633 Neighboring gene STARR-seq mESC enhancer starr_27436 Neighboring gene STARR-seq mESC enhancer starr_27437 Neighboring gene STARR-seq mESC enhancer starr_27438 Neighboring gene predicted gene, 51826 Neighboring gene four and a half LIM domains 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC58970

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
synembryn-B
Names
resistance to inhibitors of cholinesterase 8 homolog B
resistance to inhibitors of cholinesterase 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013441.2NP_001013459.1  synembryn-B isoform 1

    See identical proteins and their annotated locations for NP_001013459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AY940667, BC040762, BY272676
    Consensus CDS
    CCDS24084.1
    UniProtKB/Swiss-Prot
    Q58L65, Q80XE1
    Related
    ENSMUSP00000093032.4, ENSMUST00000095385.5
    Conserved Domains (1) summary
    pfam10165
    Location:66483
    Ric8; Guanine nucleotide exchange factor synembryn
  2. NM_183172.2NP_898995.1  synembryn-B isoform 2

    See identical proteins and their annotated locations for NP_898995.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is longer than isoform 1.
    Source sequence(s)
    BC040762, BC051080, BY272676
    Consensus CDS
    CCDS24085.1
    UniProtKB/Swiss-Prot
    Q80XE1
    Related
    ENSMUSP00000046981.8, ENSMUST00000038523.15
    Conserved Domains (1) summary
    pfam10165
    Location:66537
    Ric8; Guanine nucleotide exchange factor synembryn

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    84753136..84854201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155776.1XP_036011669.1  synembryn-B isoform X2

    Conserved Domains (1) summary
    pfam10165
    Location:66493
    Ric8; Guanine nucleotide exchange factor synembryn
  2. XM_036155777.1XP_036011670.1  synembryn-B isoform X3

    Conserved Domains (1) summary
    pfam10165
    Location:66451
    Ric8; Guanine nucleotide exchange factor synembryn
  3. XM_006513625.4XP_006513688.1  synembryn-B isoform X1

    Conserved Domains (1) summary
    pfam10165
    Location:66524
    Ric8; Guanine nucleotide exchange factor synembryn

RNA

  1. XR_380392.4 RNA Sequence

  2. XR_380394.5 RNA Sequence

  3. XR_004936177.1 RNA Sequence

  4. XR_380393.4 RNA Sequence