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LINS1 lines homolog 1 [ Homo sapiens (human) ]

Gene ID: 55180, updated on 13-Mar-2020

Summary

Official Symbol
LINS1provided by HGNC
Official Full Name
lines homolog 1provided by HGNC
Primary source
HGNC:HGNC:30922
See related
Ensembl:ENSG00000140471 MIM:610350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINS; MRT27; WINS1
Summary
The Drosophila segment polarity gene lin encodes a protein, lines, which plays important roles in development of the epidermis and hindgut. This gene encodes a protein containing a lines-like domain. This gene is located on chromosome 15 and clustered with the gene encoding ankyrin repeat and SOCS box-containing protein 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]
Expression
Ubiquitous expression in lymph node (RPKM 3.7), spleen (RPKM 2.8) and 25 other tissues See more
Orthologs

Genomic context

See LINS1 in Genome Data Viewer
Location:
15q26.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (100566914..100603032, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (101109428..101142445, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723335 Neighboring gene PRKX pseudogene 1 Neighboring gene RNA, U6 small nuclear 181, pseudogene Neighboring gene ankyrin repeat and SOCS box containing 7 Neighboring gene WD repeat domain 12 pseudogene Neighboring gene uncharacterized LOC105371024 Neighboring gene protein enabled homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of lines homolog (LINS) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10583

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
protein Lines homolog 1
Names
WINS1 protein with Drosophila Lines (Lin) homologous domain
mental retardation, non-syndromic, autosomal recessive, 27
truncated LINS1
wnt-signaling molecule Lines homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034076.2 RefSeqGene

    Range
    5849..41109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040616.3NP_001035706.2  protein Lines homolog 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC027020, AC090695
    Consensus CDS
    CCDS10385.1
    Related
    ENSP00000318423.8, ENST00000314742.13
    Conserved Domains (2) summary
    pfam14694
    Location:194542
    LINES_N; Lines N-terminus
    pfam14695
    Location:712747
    LINES_C; Lines C-terminus
  2. NM_001352507.2NP_001339436.1  protein Lines homolog 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC027020, AC090695
    Conserved Domains (2) summary
    pfam14694
    Location:1293
    LINES_N; Lines N-terminus
    pfam14695
    Location:463498
    LINES_C; Lines C-terminus
  3. NM_001352508.2NP_001339437.1  protein Lines homolog 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC027020, AC090695
    Conserved Domains (2) summary
    pfam14694
    Location:179491
    LINES_N; Lines N-terminus
    pfam14695
    Location:661696
    LINES_C; Lines C-terminus

RNA

  1. NR_148017.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC027020, AC090695
  2. NR_148018.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC027020, AC090695
  3. NR_148019.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC027020, AC090695

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    100566914..100603032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449979.1XP_024305747.1  protein Lines homolog 1 isoform X1

    Conserved Domains (2) summary
    pfam14694
    Location:194542
    LINES_N; Lines N-terminus
    pfam14695
    Location:712747
    LINES_C; Lines C-terminus
  2. XM_005254943.2XP_005255000.1  protein Lines homolog 1 isoform X2

    Conserved Domains (2) summary
    pfam14694
    Location:194506
    LINES_N; Lines N-terminus
    pfam14695
    Location:676711
    LINES_C; Lines C-terminus
  3. XM_017022400.2XP_016877889.1  protein Lines homolog 1 isoform X4

  4. XM_024449980.1XP_024305748.1  protein Lines homolog 1 isoform X1

    Conserved Domains (2) summary
    pfam14694
    Location:194542
    LINES_N; Lines N-terminus
    pfam14695
    Location:712747
    LINES_C; Lines C-terminus
  5. XM_017022399.2XP_016877888.1  protein Lines homolog 1 isoform X3

    Conserved Domains (2) summary
    pfam14694
    Location:1293
    LINES_N; Lines N-terminus
    pfam14695
    Location:463498
    LINES_C; Lines C-terminus
  6. XM_005254941.2XP_005254998.1  protein Lines homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_005254998.1

    UniProtKB/Swiss-Prot
    Q8NG48
    Conserved Domains (2) summary
    pfam14694
    Location:194542
    LINES_N; Lines N-terminus
    pfam14695
    Location:712747
    LINES_C; Lines C-terminus

RNA

  1. XR_001751348.2 RNA Sequence

  2. XR_001751346.2 RNA Sequence

  3. XR_002957655.1 RNA Sequence

  4. XR_001751347.2 RNA Sequence

  5. XR_931862.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040614.1: Suppressed sequence

    Description
    NM_001040614.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NM_001040615.1: Suppressed sequence

    Description
    NM_001040615.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  3. NM_018148.4: Suppressed sequence

    Description
    NM_018148.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  4. NM_181739.1: Suppressed sequence

    Description
    NM_181739.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  5. NM_181740.1: Suppressed sequence

    Description
    NM_181740.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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