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Lins1 lines homolog 1 [ Mus musculus (house mouse) ]

Gene ID: 72635, updated on 5-Mar-2024

Summary

Official Symbol
Lins1provided by MGI
Official Full Name
lines homolog 1provided by MGI
Primary source
MGI:MGI:1919885
See related
Ensembl:ENSMUSG00000053091 AllianceGenome:MGI:1919885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lins; Lins2; Wins2; 2700083B01Rik
Summary
Predicted to be involved in cognition. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human LINS1 (lines homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.6), CNS E14 (RPKM 3.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 C; 7 36.08 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (66339565..66367004)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (66689817..66717256)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19085 Neighboring gene STARR-seq mESC enhancer starr_19088 Neighboring gene predicted gene, 53392 Neighboring gene predicted gene, 33570 Neighboring gene STARR-seq mESC enhancer starr_19090 Neighboring gene STARR-positive B cell enhancer ABC_E11356 Neighboring gene STARR-positive B cell enhancer ABC_E1735 Neighboring gene ankyrin repeat and SOCS box-containing 7 Neighboring gene STARR-seq mESC enhancer starr_19091 Neighboring gene ceramide synthase 3 Neighboring gene predicted gene, 33627 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 17

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
protein Lines homolog 1
Names
Wins2 protein with Drosophila Lin homologous domain
lines homolog 2
protein Lines homolog 2
protein with Drosophila Lines homologous domain
wnt-signaling molecule Lines homolog 1
wnt-signaling molecule Lines homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191001.1NP_001177930.1  protein Lines homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001177930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC120791
    Consensus CDS
    CCDS57555.1
    UniProtKB/Swiss-Prot
    Q3U1D0
    Related
    ENSMUSP00000077117.7, ENSMUST00000077967.13
    Conserved Domains (2) summary
    pfam14694
    Location:205553
    LINES_N; Lines N-terminus
    pfam14695
    Location:718754
    LINES_C; Lines C-terminus
  2. NM_152815.2NP_690028.2  protein Lines homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_690028.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC120791
    Consensus CDS
    CCDS21348.2
    UniProtKB/Swiss-Prot
    Q3TBL8, Q3U1D0, Q6PCP6, Q8K4P9
    Related
    ENSMUSP00000112404.3, ENSMUST00000121777.9
    Conserved Domains (2) summary
    pfam14694
    Location:211558
    LINES_N; Lines N-terminus
    pfam14695
    Location:723758
    LINES_C; Lines C-terminus

RNA

  1. NR_034030.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC120791, BC058648
    Related
    ENSMUST00000130161.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    66339565..66367004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541219.4XP_006541282.1  protein Lines homolog 1 isoform X2

    Conserved Domains (2) summary
    pfam14694
    Location:175523
    LINES_N; Lines N-terminus
    pfam14695
    Location:688724
    LINES_C; Lines C-terminus
  2. XM_006541218.5XP_006541281.1  protein Lines homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006541281.1

    UniProtKB/Swiss-Prot
    Q3U1D0
    Conserved Domains (2) summary
    pfam14694
    Location:205553
    LINES_N; Lines N-terminus
    pfam14695
    Location:718754
    LINES_C; Lines C-terminus
  3. XM_036153460.1XP_036009353.1  protein Lines homolog 1 isoform X6

    Conserved Domains (2) summary
    pfam14694
    Location:1292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457493
    LINES_C; Lines C-terminus
  4. XM_030243014.1XP_030098874.1  protein Lines homolog 1 isoform X6

    Conserved Domains (2) summary
    pfam14694
    Location:1292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457493
    LINES_C; Lines C-terminus
  5. XM_006541217.5XP_006541280.1  protein Lines homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006541280.1

    UniProtKB/Swiss-Prot
    Q3U1D0
    Conserved Domains (2) summary
    pfam14694
    Location:205553
    LINES_N; Lines N-terminus
    pfam14695
    Location:718754
    LINES_C; Lines C-terminus
  6. XM_030243012.2XP_030098872.1  protein Lines homolog 1 isoform X4

    Conserved Domains (2) summary
    pfam14694
    Location:144492
    LINES_N; Lines N-terminus
    pfam14695
    Location:657693
    LINES_C; Lines C-terminus
  7. XM_006541220.5XP_006541283.1  protein Lines homolog 1 isoform X3

    Conserved Domains (2) summary
    pfam14694
    Location:174522
    LINES_N; Lines N-terminus
    pfam14695
    Location:687723
    LINES_C; Lines C-terminus
  8. XM_011250905.4XP_011249207.1  protein Lines homolog 1 isoform X6

    See identical proteins and their annotated locations for XP_011249207.1

    UniProtKB/Swiss-Prot
    Q3U1D0
    Conserved Domains (2) summary
    pfam14694
    Location:1292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457493
    LINES_C; Lines C-terminus
  9. XM_036153457.1XP_036009350.1  protein Lines homolog 1 isoform X4

    Conserved Domains (2) summary
    pfam14694
    Location:144492
    LINES_N; Lines N-terminus
    pfam14695
    Location:657693
    LINES_C; Lines C-terminus
  10. XM_036153458.1XP_036009351.1  protein Lines homolog 1 isoform X5

    Conserved Domains (2) summary
    pfam14694
    Location:146452
    LINES_N; Lines N-terminus
    pfam14695
    Location:617653
    LINES_C; Lines C-terminus
  11. XM_036153459.1XP_036009352.1  protein Lines homolog 1 isoform X6

    Conserved Domains (2) summary
    pfam14694
    Location:1292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457493
    LINES_C; Lines C-terminus
  12. XM_017312329.1XP_017167818.1  protein Lines homolog 1 isoform X6

    UniProtKB/Swiss-Prot
    Q3U1D0
    Conserved Domains (2) summary
    pfam14694
    Location:1292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457493
    LINES_C; Lines C-terminus
  13. XM_036153461.1XP_036009354.1  protein Lines homolog 1 isoform X6

    Conserved Domains (2) summary
    pfam14694
    Location:1292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457493
    LINES_C; Lines C-terminus