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PPP2CB protein phosphatase 2 catalytic subunit beta [ Homo sapiens (human) ]

Gene ID: 5516, updated on 7-Jun-2020

Summary

Official Symbol
PPP2CBprovided by HGNC
Official Full Name
protein phosphatase 2 catalytic subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9300
See related
Ensembl:ENSG00000104695 MIM:176916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2CB; PP2Abeta
Summary
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in brain (RPKM 83.4), thyroid (RPKM 78.1) and 24 other tissues See more
Orthologs

Genomic context

See PPP2CB in Genome Data Viewer
Location:
8p12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30785616..30812818, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30643126..30670352, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene glutathione-disulfide reductase Neighboring gene uncharacterized LOC105379356 Neighboring gene uncharacterized LOC105379355 Neighboring gene UBX domain protein 8 Neighboring gene testis expressed 15, meiosis and synapsis associated Neighboring gene uncharacterized LOC105379357 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1136

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with protein phosphatase 2, catalytic subunit, beta isozyme (PPP2CB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
Vpu vpu IFN-alpha and IFN-beta increases SCYL2 expression and the increase induces PP2A-mediated dephosphorylation of Vpu, suggesting that SCYL2 affects Vpu function through a phosphorylation-dependent mechanism PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic mitochondrial changes IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
peptidyl-threonine dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to lead ion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase type 2A complex TAS
Traceable Author Statement
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Names
PP2A-beta
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
protein phosphatase 2, catalytic subunit, beta isoform
protein phosphatase 2, catalytic subunit, beta isozyme
protein phosphatase 2A catalytic subunit, beta isoform
protein phosphatase type 2A catalytic subunit
serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform
testicular tissue protein Li 146
NP_001009552.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009552.2NP_001009552.1  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

    See identical proteins and their annotated locations for NP_001009552.1

    Status: REVIEWED

    Source sequence(s)
    AC009314, BC012022, BG716837, CA419001, CF594136
    Consensus CDS
    CCDS6079.1
    UniProtKB/Swiss-Prot
    P62714
    UniProtKB/TrEMBL
    A0A140VJS0
    Related
    ENSP00000221138.4, ENST00000221138.9
    Conserved Domains (1) summary
    cd07415
    Location:9293
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    30785616..30812818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004156.2: Suppressed sequence

    Description
    NM_004156.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support a splice pattern with non-consensus splice sites in the 5' UTR.
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