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Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [ Mus musculus (house mouse) ]

Gene ID: 19053, updated on 6-Jun-2024

Summary

Official Symbol
Ppp2cbprovided by MGI
Official Full Name
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformprovided by MGI
Primary source
MGI:MGI:1321161
See related
Ensembl:ENSMUSG00000009630 AllianceGenome:MGI:1321161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PP2Ac; D8Ertd766e
Summary
Predicted to enable protein C-terminus binding activity and protein serine/threonine phosphatase activity. Acts upstream of or within several processes, including apoptotic mitochondrial changes; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to hydrogen peroxide. Located in cytoplasm. Part of protein phosphatase type 2A complex. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; gut; and nervous system. Orthologous to human PPP2CB (protein phosphatase 2 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 44.0), testis adult (RPKM 44.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ppp2cb in Genome Data Viewer
Location:
8 A4; 8 20.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34089672..34109831)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33599621..33619804)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 1, related sequence 17 Neighboring gene STARR-seq mESC enhancer starr_21108 Neighboring gene testis expressed gene 15 meiosis and synapsis associated Neighboring gene STARR-seq mESC enhancer starr_21109 Neighboring gene UBX domain protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E4996 Neighboring gene STARR-seq mESC enhancer starr_21112 Neighboring gene predicted gene, 33433 Neighboring gene glutathione reductase Neighboring gene predicted gene, 24727

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Names
PP2A-beta
NP_001411800.1
NP_059070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424871.1NP_001411800.1  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139025
    UniProtKB/TrEMBL
    Q8BN07
  2. NM_017374.4NP_059070.1  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform 1

    See identical proteins and their annotated locations for NP_059070.1

    Status: VALIDATED

    Source sequence(s)
    AC139025
    Consensus CDS
    CCDS22233.1
    UniProtKB/Swiss-Prot
    P62715
    UniProtKB/TrEMBL
    Q8BN07
    Related
    ENSMUSP00000009774.10, ENSMUST00000009774.11
    Conserved Domains (1) summary
    cd07415
    Location:9293
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34089672..34109831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)