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PPP1R7 protein phosphatase 1 regulatory subunit 7 [ Homo sapiens (human) ]

Gene ID: 5510, updated on 24-Nov-2020

Summary

Official Symbol
PPP1R7provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 7provided by HGNC
Primary source
HGNC:HGNC:9295
See related
Ensembl:ENSG00000115685 MIM:602877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDS22
Summary
This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Broad expression in testis (RPKM 40.9), brain (RPKM 18.7) and 25 other tissues See more
Orthologs

Genomic context

See PPP1R7 in Genome Data Viewer
Location:
2q37.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (241149573..241183652)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242089012..242122439)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SNED1 antisense RNA 1 Neighboring gene sushi, nidogen and EGF like domains 1 Neighboring gene mitochondrial transcription termination factor 4 Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene uncharacterized LOC105373971 Neighboring gene anoctamin 7 Neighboring gene uncharacterized LOC105376810 Neighboring gene high density lipoprotein binding protein Neighboring gene uncharacterized LOC101927509

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 7
Names
protein phosphatase 1 regulatory subunit 22
protein phosphatase 1, regulatory (inhibitor) subunit 7
testis secretory sperm-binding protein Li 210a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282409.1NP_001269338.1  protein phosphatase 1 regulatory subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001269338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 2, also known as sds22alpha2) is shorter compared to isoform 1.
    Source sequence(s)
    AC005237, BC051689, BM676947
    Consensus CDS
    CCDS63194.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000272983.8, ENST00000272983.12
    Conserved Domains (3) summary
    smart00446
    Location:293311
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:5778
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:44274
    internalin_A; class 1 internalin InlA
  2. NM_001282410.1NP_001269339.1  protein phosphatase 1 regulatory subunit 7 isoform 3

    See identical proteins and their annotated locations for NP_001269339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded protein (isoform 3, also known as sds22beta1) is shorter compared to isoform 1.
    Source sequence(s)
    AC005237, BC013001, BC051689
    Consensus CDS
    CCDS63192.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000385022.3, ENST00000406106.7
    Conserved Domains (2) summary
    COG4886
    Location:108272
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:100121
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_001282411.1NP_001269340.1  protein phosphatase 1 regulatory subunit 7 isoform 4

    See identical proteins and their annotated locations for NP_001269340.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks alternate exons in the coding region and uses an alternate 3' terminal exon compared to variant 1. The encoded protein (isoform 4, also known as sds22beta2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC005237, BC013001, BC051689, BG684153
    Consensus CDS
    CCDS63193.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000385466.1, ENST00000401987.5
    Conserved Domains (3) summary
    sd00033
    Location:5778
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:165207
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:165221
    LRR_8; Leucine rich repeat
  4. NM_001282412.1NP_001269341.1  protein phosphatase 1 regulatory subunit 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 5) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC005237, AK308015, BC000910, BM676947, DA787059
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000392373.1, ENST00000450367.1
    Conserved Domains (3) summary
    smart00446
    Location:320338
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:84105
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:71301
    internalin_A; class 1 internalin InlA
  5. NM_001282413.1NP_001269342.1  protein phosphatase 1 regulatory subunit 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 6) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC005237, AK308015, BC000910, BI256145, BM676947, DA787059
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000412092.1, ENST00000423280.5
    Conserved Domains (4) summary
    smart00446
    Location:277295
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:4162
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:149191
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:171227
    LRR_8; Leucine rich repeat
  6. NM_001282414.1NP_001269343.1  protein phosphatase 1 regulatory subunit 7 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and has multiple coding region differences compared to variant 1. The encoded protein (isoform 7) is shorter and has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC005237, BC013001, BQ212238, DA787059
    Consensus CDS
    CCDS63190.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000385012.1, ENST00000402734.5
    Conserved Domains (3) summary
    sd00033
    Location:4162
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:149191
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:149205
    LRR_8; Leucine rich repeat
  7. NM_002712.3NP_002703.1  protein phosphatase 1 regulatory subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_002703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as sds22alpha1).
    Source sequence(s)
    AC005237, BC000910, BC051689, BM676947
    Consensus CDS
    CCDS2546.1
    UniProtKB/Swiss-Prot
    Q15435
    UniProtKB/TrEMBL
    A0A140VK83
    Related
    ENSP00000234038.6, ENST00000234038.11
    Conserved Domains (3) summary
    smart00446
    Location:336354
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:100121
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:87317
    internalin_A; class 1 internalin InlA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    241149573..241183652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511388.2XP_011509690.1  protein phosphatase 1 regulatory subunit 7 isoform X1

    Conserved Domains (3) summary
    smart00446
    Location:268286
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:3253
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:19249
    internalin_A; class 1 internalin InlA
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