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FEBS Lett. 1995 Nov 13;375(1-2):75-8.

Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1.

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  • 1Afdeling Biochemie, Faculteit Geneeskunde, Katholicke Universiteit Leuven, Belgium.


sds22 is a regulatory polypeptide of protein phosphatase-1 that is required for the completion of mitosis in both fission and budding yeast. We report here the cDNA cloning of a human polypeptide that is 46% identical to yeast sds22. The human homolog of sds22 consists of 360 residues, has a calculated molecular mass of 41.6 kDa and shows a tandem array of 11 leucine-rich repeat structures of 22 residues. Northern analysis revealed a major transcript of 1.39 kb in all 8 investigated human tissues. sds22 was detected by western analysis in both the cytoplasm and the nucleus of rat liver cells as a polypeptide of 44 kDa.

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