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KIF26B kinesin family member 26B [ Homo sapiens (human) ]

Gene ID: 55083, updated on 5-Nov-2019

Summary

Official Symbol
KIF26Bprovided by HGNC
Official Full Name
kinesin family member 26Bprovided by HGNC
Primary source
HGNC:HGNC:25484
See related
Ensembl:ENSG00000162849 MIM:614026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]
Expression
Broad expression in placenta (RPKM 1.6), endometrium (RPKM 0.9) and 19 other tissues See more
Orthologs

Genomic context

See KIF26B in Genome Data Viewer
Location:
1q44
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (245154985..245709432)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (245318287..245866428)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 2 Neighboring gene RNA, U6 small nuclear 999, pseudogene Neighboring gene RNA, U1 small nuclear 132, pseudogene Neighboring gene KIF26B antisense RNA 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 8 Neighboring gene uncharacterized LOC105373266 Neighboring gene uncharacterized LOC105373265 Neighboring gene uncharacterized LOC105373270 Neighboring gene uncharacterized LOC105373269 Neighboring gene SET and MYND domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV Vif interacts with KIF26B PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10157, MGC35030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
NOT microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
ureteric bud invasion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF26B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053061.1 RefSeqGene

    Range
    5001..559448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018012.4NP_060482.2  kinesin-like protein KIF26B

    See identical proteins and their annotated locations for NP_060482.2

    Status: REVIEWED

    Source sequence(s)
    AC104462, AY923834
    Consensus CDS
    CCDS44342.1
    UniProtKB/Swiss-Prot
    Q2KJY2
    Related
    ENSP00000385545.2, ENST00000407071.7
    Conserved Domains (2) summary
    smart00129
    Location:451798
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00106
    Location:450798
    KISc; Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    245154985..245709432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187516.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    46764..407457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017030182.1XP_016885671.1  kinesin-like protein KIF26B isoform X1

    Conserved Domains (2) summary
    smart00129
    Location:251598
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00106
    Location:250598
    KISc; Kinesin motor domain
  2. XM_017030183.1XP_016885672.1  kinesin-like protein KIF26B isoform X2

    UniProtKB/TrEMBL
    B7WPD9
    Conserved Domains (2) summary
    smart00129
    Location:70417
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00106
    Location:69417
    KISc; Kinesin motor domain
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