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KIF26B kinesin family member 26B [ Homo sapiens (human) ]

Gene ID: 55083, updated on 17-Jun-2024

Summary

Official Symbol
KIF26Bprovided by HGNC
Official Full Name
kinesin family member 26Bprovided by HGNC
Primary source
HGNC:HGNC:25484
See related
Ensembl:ENSG00000162849 MIM:614026; AllianceGenome:HGNC:25484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]
Expression
Broad expression in placenta (RPKM 1.6), endometrium (RPKM 0.9) and 19 other tissues See more
Orthologs
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Genomic context

See KIF26B in Genome Data Viewer
Location:
1q44
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (245154985..245709432)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (244572450..245130184)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (245318287..245872734)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245316423-245317098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245317099-245317774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245343249-245343749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245342748-245343248 Neighboring gene RNA, U1 small nuclear 132, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:245358334-245359141 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:245366003-245366213 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:245376557-245377756 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:245397844-245398363 Neighboring gene KIF26B antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:245419187-245420056 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245420057-245420924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245421793-245422660 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:245474556-245474731 Neighboring gene Sharpr-MPRA regulatory region 12100 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 8 Neighboring gene NANOG hESC enhancer GRCh37_chr1:245629563-245630064 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:245630817-245632016 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:245647215-245647978 Neighboring gene uncharacterized LOC124904571 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:245746285-245747484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245769345-245770175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245774720-245775220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245775221-245775721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245786008-245786527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245811797-245812310 Neighboring gene uncharacterized LOC105373265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245874821-245875320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245874319-245874820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:245878266-245878766 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:245926173-245926700 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245937857-245938697 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245938698-245939538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245979520-245980135 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:245980136-245980750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246016290-246016790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246016791-246017291 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:246032999-246034198 Neighboring gene SET and MYND domain containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:246111472-246111972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:246226795-246227321 Neighboring gene NANOG hESC enhancer GRCh37_chr1:246228833-246229369 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246273353-246273854 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:246273855-246274354 Neighboring gene Sharpr-MPRA regulatory region 4643 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:246302792-246303991 Neighboring gene CRISPRi-validated SMYD3 hub enhancer Neighboring gene SMYD3 antisense RNA 1 Neighboring gene CRISPRi-validated SMYD3 non-hub enhancer Neighboring gene CRISPR perturbation-validated SMYD3 cis-regulatory element TAD4.SE2.HS8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2030 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV Vif interacts with KIF26B PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10157, MGC35030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in ureteric bud invasion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin-like protein KIF26B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053061.1 RefSeqGene

    Range
    5001..559448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018012.4NP_060482.2  kinesin-like protein KIF26B

    See identical proteins and their annotated locations for NP_060482.2

    Status: REVIEWED

    Source sequence(s)
    AC104462, AY923834
    Consensus CDS
    CCDS44342.1
    UniProtKB/Swiss-Prot
    Q2KJY2, Q6ZQR9, Q6ZUZ0, Q8IUN3, Q8IVR1, Q9NWB4
    UniProtKB/TrEMBL
    A0A0G2JR66
    Related
    ENSP00000385545.2, ENST00000407071.7
    Conserved Domains (2) summary
    smart00129
    Location:451798
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00106
    Location:450798
    KISc; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    245154985..245709432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187516.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    46767..407457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017030182.2XP_016885671.1  kinesin-like protein KIF26B isoform X1

    UniProtKB/TrEMBL
    A0A0G2JR66
    Conserved Domains (2) summary
    smart00129
    Location:251598
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00106
    Location:250598
    KISc; Kinesin motor domain
  2. XM_017030183.1XP_016885672.1  kinesin-like protein KIF26B isoform X2

    UniProtKB/TrEMBL
    A0A0G2JR66, B7WPD9
    Conserved Domains (2) summary
    smart00129
    Location:70417
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00106
    Location:69417
    KISc; Kinesin motor domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    244572450..245130184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)