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ZCWPW1 zinc finger CW-type and PWWP domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55063, updated on 10-Dec-2019

Summary

Official Symbol
ZCWPW1provided by HGNC
Official Full Name
zinc finger CW-type and PWWP domain containing 1provided by HGNC
Primary source
HGNC:HGNC:23486
See related
Ensembl:ENSG00000078487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZCW1
Expression
Broad expression in testis (RPKM 25.2), thyroid (RPKM 2.9) and 16 other tissues See more
Orthologs

Genomic context

See ZCWPW1 in Genome Data Viewer
Location:
7q22.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100400816..100429996, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99998449..100027037, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene STAG3L5P-PVRIG2P-PILRB readthrough Neighboring gene paired immunoglobin like type 2 receptor beta Neighboring gene paired immunoglobin like type 2 receptor alpha Neighboring gene PPP1R35 antisense RNA 1 Neighboring gene methylphosphate capping enzyme Neighboring gene protein phosphatase 1 regulatory subunit 35 Neighboring gene chromosome 7 open reading frame 61

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10057, DKFZp434N0510

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger CW-type PWWP domain protein 1
Names
zinc finger CW-type and PWWP domain 1
zinc finger, CW-type with PWWP domain 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258008.2NP_001244937.1  zinc finger CW-type PWWP domain protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001244937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon and lacks two 3' coding exons compared to variant 1, that causes a frameshift. The resulting isoform (2) lacks a 1 aa internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC005071, AK300745, AL136735, DB447154, DC413605
    Consensus CDS
    CCDS59067.1
    UniProtKB/Swiss-Prot
    Q9H0M4
    Related
    ENSP00000354210.4, ENST00000360951.8
    Conserved Domains (2) summary
    pfam07496
    Location:257302
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:314417
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  2. NM_017984.5NP_060454.3  zinc finger CW-type PWWP domain protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060454.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC005071, AL136735, DB447154
    Consensus CDS
    CCDS43623.1
    UniProtKB/Swiss-Prot
    Q9H0M4
    Related
    ENSP00000381109.2, ENST00000398027.6
    Conserved Domains (2) summary
    cd05837
    Location:313416
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:256301
    zf-CW; CW-type Zinc Finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100400816..100429996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716038.4XP_006716101.1  zinc finger CW-type PWWP domain protein 1 isoform X3

    Conserved Domains (2) summary
    cd05837
    Location:314417
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:256302
    zf-CW; CW-type Zinc Finger
  2. XM_024446815.1XP_024302583.1  zinc finger CW-type PWWP domain protein 1 isoform X5

    Conserved Domains (2) summary
    pfam07496
    Location:257302
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:314385
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  3. XM_006716037.4XP_006716100.1  zinc finger CW-type PWWP domain protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006716100.1

    Conserved Domains (2) summary
    cd05837
    Location:314417
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:257302
    zf-CW; CW-type Zinc Finger
  4. XM_006716040.4XP_006716103.1  zinc finger CW-type PWWP domain protein 1 isoform X4

    Conserved Domains (2) summary
    pfam07496
    Location:257303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315386
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  5. XM_006716035.4XP_006716098.1  zinc finger CW-type PWWP domain protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006716098.1

    Conserved Domains (2) summary
    cd05837
    Location:315418
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:257303
    zf-CW; CW-type Zinc Finger
  6. XM_006716036.3XP_006716099.1  zinc finger CW-type PWWP domain protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006716099.1

    Conserved Domains (2) summary
    cd05837
    Location:315418
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    pfam07496
    Location:257303
    zf-CW; CW-type Zinc Finger
  7. XM_017012379.2XP_016867868.1  zinc finger CW-type PWWP domain protein 1 isoform X8

  8. XM_005250480.3XP_005250537.1  zinc finger CW-type PWWP domain protein 1 isoform X7

    Conserved Domains (2) summary
    pfam07496
    Location:257303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315386
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  9. XM_005250479.3XP_005250536.1  zinc finger CW-type PWWP domain protein 1 isoform X6

    Conserved Domains (2) summary
    pfam07496
    Location:257303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315418
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  10. XM_017012380.2XP_016867869.1  zinc finger CW-type PWWP domain protein 1 isoform X8

  11. XM_024446816.1XP_024302584.1  zinc finger CW-type PWWP domain protein 1 isoform X6

    Conserved Domains (2) summary
    pfam07496
    Location:257303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315418
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  12. XM_024446818.1XP_024302586.1  zinc finger CW-type PWWP domain protein 1 isoform X10

    Conserved Domains (2) summary
    pfam07496
    Location:257302
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:314330
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  13. XM_024446817.1XP_024302585.1  zinc finger CW-type PWWP domain protein 1 isoform X9

    Conserved Domains (2) summary
    pfam07496
    Location:257303
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:315331
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
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