Conserved Protein Domain Family
MSH6_like

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cd05837: MSH6_like 
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The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been linked to increased cancer susceptibility, particularly in hereditary nonpolyposis colorectal cancer in humans. The role of the PWWP domain in MSH6 is not clear; MSH6 orthologs found in S. cerevisiae, Caenorhabditis elegans and Arabidopsis thaliana lack the PWWP domain. Histone methyltransferases (HMTases) induce the posttranslational methylation of lysine residues in histones and play a role in apoptosis. In the HMTase Whistle, the PWWP domain is necessary for HMTase activity. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
BioAssay Targets and Results
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CID: 13817
AID: 624260
GI: 109633019
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NSD2 Inhibitors Measured in Biochemical System Using Plate Reader - 2115-01_Inhibitor_SinglePoint_HTS_Activity
Chemical Name: Fast Scarlet
CID: 481747
AID: 624260
GI: 109633019
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NSD2 Inhibitors Measured in Biochemical System Using Plate Reader - 2115-01_Inhibitor_SinglePoint_HTS_Activity
Chemical Name: Cdk4 Inhibitor III
CID: 3032583
AID: 624260
GI: 109633019
more
NSD2 Inhibitors Measured in Biochemical System Using Plate Reader - 2115-01_Inhibitor_SinglePoint_HTS_Activity
Chemical Name: cis-Tamoxifen
Statistics
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PSSM-Id: 99898
View PSSM: cd05837
Aligned: 14 rows
Threshold Bit Score: 144.451
Threshold Setting Gi: 51702190
Created: 27-Nov-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

cd05837 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd05837 is a member of the superfamily cl02554.
cd05162:PWWPcd05834:HDGF_relatedcd05835:Dnmt3b_relatedcd05836:N_Pac_NP60cd05837:MSH6_likecd05838:WHSC1_relatedcd05839:BR140_relatedcd05840:SPBC215_ISWI_likecd05841:BS69_relatedcd06080:MUM1_like156545191294278332GFU A14823686311808763411590840551702190156383864324697697470609614822908211810138874761342115768291156545191294278332GFU A14823686311808763411590840551702190156383864324697697470609614822908211810138874761342115768291
cd05837 Sequence Cluster
cd05837 Sequence Cluster
Sub-family Hierarchy
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 cd05837 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #  #  #                                     #   # #                 
2GFU_A         21 SDFSPGDLVWAKMEGYPWWPSLVYNHPfdgtfi-----------rekgkSVRVHVQFFDDSPTRGWVSKRLLKPytgsks 89
gi 118087634  203 GVYSPGDLVWAKMEGYPWWPCLIYNHPtegtiv-----------rgkgsSARIHVQFFDVSPTRGWVSIKYLRPykgssd 271
gi 115908405   60 QTFAPGDLVWARLEGYPWWPSLVCNHPtlekct-----------kkegrKGLVHVQFFDDPPSRAWISDKFIEGyngsra 128
gi 148236863   77 CDFNPGDLVWAKMLGHPWWPSLVYNHPkegthl-----------rgkgkSLHVHVQFFDDSPTRGWTGAKYIKPfsgsta 145
gi 156545191   72 STWELGTLAWARMSIYPFWPCMITHDPnspmiyqk------vqtvgkskTLMIHVHFFNDNGRHSWIPSHHMLHfdngie 145
gi 29427833   391 PTYQVGDLFWGKVFSYCFWPCMVCPDPlgqivgnmpshpqrssldnanvPIQVHVRFFADNGRRNWIKPENLLTfaglka 470
gi 118101388  266 IKFQVGDLVWSKVGTYPWWPCMVSCDPqldvht----------kintrgAREYHVQFFSNQPERAWVHEKRVREykghkq 335
gi 51702190   313 ASYIPGSIIWAKQYGYPWWPGMIESDPdlgeyflf-------tshldslPSKYHVTFFGETVSRAWIPVNMLKNfqels- 384
gi 115768291  332 CEWLVGDLVWSKVSGHPWWPCMVAYDPnlgiytrm-------kgsigktYRMYHVQFFGEVPERGWVSGSSMKKfsgrdq 404
gi 74761342   266 VKFQVGDLVWSKVGTYPWWPCMVSSDPqlevht----------kintrgAREYHVQFFSNQPERAWVHEKRVREykghkq 335
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                              
2GFU_A         90 ke--------------aqkgghfySAKPEILRAMQRADEALnkdkIKRLELAV 128
gi 118087634  272 re--------------vlkggmfySMKPEIKKAMELADDAMskdkTKRLELAV 310
gi 115908405  129 ke--------------cqfgckfhTTKPDVRRGMDQADEALkkdrEERMELVV 167
gi 148236863  146 ae--------------tqkggmffSTKPEIKKAMKMADDAVtldkQKRLELAV 184
gi 156545191  146 dfrkraslvtdiirkkepkfaaalTIKPNIYGTWQKAVAEAmd-vLYEIDMSP 197
gi 29427833   471 fd--------------dmreelriKHGPKSAKYRQMVPKRTkv-vIWRQAIEE 508
gi 118101388  336 yeqllae----aakqasnhsekqkIRKPRPQRERAQWDIGIah-aEKALKMTR 383
gi 51702190   385 --------------------lelsVMKKRRNDCSQKLGVALmm-aQEAEQISI 416
gi 115768291  405 ydslveemvskvrkaersrmlsklAVKPCRRNAWDAAISEC----EKALPMSR 453
gi 74761342   336 yeellae----atkqasnhsekqkIRKPRPQRERAQWDIGIah-aEKALKMTR 383

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