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Zcwpw1 zinc finger, CW type with PWWP domain 1 [ Mus musculus (house mouse) ]

Gene ID: 381678, updated on 8-Feb-2024

Summary

Official Symbol
Zcwpw1provided by MGI
Official Full Name
zinc finger, CW type with PWWP domain 1provided by MGI
Primary source
MGI:MGI:2685899
See related
Ensembl:ENSMUSG00000037108 AllianceGenome:MGI:2685899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1053
Summary
Enables methylated histone binding activity. Involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Acts upstream of or within homologous chromosome pairing at meiosis. Located in XY body and nucleus. Is expressed in brain; lung; reproductive system; and thymus. Orthologous to human ZCWPW1 (zinc finger CW-type and PWWP domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 4.2), testis adult (RPKM 3.8) and 22 other tissues See more
Orthologs
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Genomic context

See Zcwpw1 in Genome Data Viewer
Location:
5 G2; 5 76.71 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137785593..137820883)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137787157..137822621)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57848 Neighboring gene sperm acrosome developmental regulator Neighboring gene STARR-positive B cell enhancer ABC_E4797 Neighboring gene STARR-positive B cell enhancer ABC_E857 Neighboring gene STARR-positive B cell enhancer ABC_E1312 Neighboring gene protein phosphatase 1, regulatory subunit 35 Neighboring gene STARR-positive B cell enhancer ABC_E4798 Neighboring gene methylphosphate capping enzyme Neighboring gene STARR-seq mESC enhancer starr_14656 Neighboring gene paired immunoglobin-like type 2 receptor alpha Neighboring gene STARR-seq mESC enhancer starr_14658 Neighboring gene paired immunoglobin-like type 2 receptor beta 1 Neighboring gene predicted gene, 36551 Neighboring gene paired immunoglobin-like type 2 receptor beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Clone Names

  • MGC76794

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone reader activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger CW-type PWWP domain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005426.2NP_001005426.2  zinc finger CW-type PWWP domain protein 1

    See identical proteins and their annotated locations for NP_001005426.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK080079, BC071186, CF982070
    Consensus CDS
    CCDS19779.1
    UniProtKB/Swiss-Prot
    Q2YFS4, Q6IR42
    Related
    ENSMUSP00000048730.8, ENSMUST00000035852.14
    Conserved Domains (3) summary
    pfam07496
    Location:247292
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:304406
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    cl25732
    Location:76228
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001360023.1NP_001346952.1  zinc finger CW-type PWWP domain protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC125063
    Consensus CDS
    CCDS19779.1
    UniProtKB/Swiss-Prot
    Q2YFS4, Q6IR42
    Conserved Domains (3) summary
    pfam07496
    Location:247292
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:304406
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    cl25732
    Location:76228
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137785593..137820883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254625.2XP_030110485.1  zinc finger CW-type PWWP domain protein 1 isoform X3

    Conserved Domains (3) summary
    pfam05483
    Location:76228
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam07496
    Location:247292
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:304375
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  2. XM_036165244.1XP_036021137.1  zinc finger CW-type PWWP domain protein 1 isoform X1

    Conserved Domains (2) summary
    pfam07496
    Location:247292
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:304406
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  3. XM_036165243.1XP_036021136.1  zinc finger CW-type PWWP domain protein 1 isoform X1

    Conserved Domains (2) summary
    pfam07496
    Location:247292
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:304406
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  4. XM_036165245.1XP_036021138.1  zinc finger CW-type PWWP domain protein 1 isoform X2

    Conserved Domains (2) summary
    pfam07496
    Location:247292
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:304375
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  5. XM_006504585.4XP_006504648.1  zinc finger CW-type PWWP domain protein 1 isoform X3

    Conserved Domains (3) summary
    pfam05483
    Location:76228
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam07496
    Location:247292
    zf-CW; CW-type Zinc Finger
    cl02554
    Location:304375
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  6. XM_036165246.1XP_036021139.1  zinc finger CW-type PWWP domain protein 1 isoform X4

    Conserved Domains (1) summary
    cl02554
    Location:182
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...