Format

Send to:

Choose Destination

PPP1CB protein phosphatase 1 catalytic subunit beta [ Homo sapiens (human) ]

Gene ID: 5500, updated on 24-Nov-2020

Summary

Official Symbol
PPP1CBprovided by HGNC
Official Full Name
protein phosphatase 1 catalytic subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9282
See related
Ensembl:ENSG00000213639 MIM:600590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MP; PP1B; PP1c; NSLH2; PP-1B; PPP1CD; PP1beta; PPP1beta; HEL-S-80p
Summary
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 80.9), prostate (RPKM 58.5) and 25 other tissues See more
Orthologs

Genomic context

See PPP1CB in Genome Data Viewer
Location:
2p23.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (28751604..28802940)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (28974614..29025806)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 89 Neighboring gene uncharacterized LOC100505774 Neighboring gene uncharacterized LOC112267877 Neighboring gene speedy/RINGO cell cycle regulator family member A Neighboring gene tRNA methyltransferase 61B Neighboring gene WD repeat domain 43 Neighboring gene small nucleolar RNA, C/D box 92

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
Tat tat Protein phosphatase 1, catalytic subunit, beta isoform (PPP1CB) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat Small molecular compounds prevent the interaction of HIV-1 Tat with protein phosphatase-1 (PP1) and the shuttling of PP1 to the nucleus PubMed
tat PP1 interacts with Tat in part through the binding of Val(36) and Phe(38) of Tat to PP1, and Tat is involved in the nuclear and subnuclear targeting of PP1 PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat Stimulation of HIV-1 Tat transactivation by protein phosphatase 1 (PP1) is inhibited by nuclear inhibitor of PP1 (NIPP1), indicating Tat function is regulated by PP1/NIPP1 PubMed
tat Protein phosphatase 1 (PP1) associates with HIV-1 Tat and stimulates Tat-mediated transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SPDYA

Homology

Clone Names

  • MGC3672

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
myosin phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
myosin-light-chain-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PTW/PP1 phosphatase complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
glycogen granule IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein phosphatase type 1 complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase PP1-beta catalytic subunit
Names
epididymis secretory sperm binding protein Li 80p
myosin phosphatase
protein phosphatase 1, catalytic subunit, beta isozyme
protein phosphatase 1-beta
protein phosphatase 1-delta
NP_002700.1
NP_996759.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052878.1 RefSeqGene

    Range
    5001..56193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002709.3NP_002700.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_002700.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. It encodes the longer isoform (1).
    Source sequence(s)
    BC002697, BE047402, BM835970, BX477003, BX647295, CD722576, X80910
    Consensus CDS
    CCDS33169.1
    UniProtKB/Swiss-Prot
    P62140
    UniProtKB/TrEMBL
    V9HW04
    Related
    ENSP00000378769.2, ENST00000395366.3
    Conserved Domains (1) summary
    cd07414
    Location:7297
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
  2. NM_206876.2NP_996759.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_996759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC097724, AF092905, BE047402, BI551898, BM835970, BQ933435, CB111140, CD656807, CD722576, X80910
    Consensus CDS
    CCDS33169.1
    UniProtKB/Swiss-Prot
    P62140
    UniProtKB/TrEMBL
    V9HW04
    Related
    ENSP00000351298.2, ENST00000358506.6
    Conserved Domains (1) summary
    cd07414
    Location:7297
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    28751604..28802940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206877.1: Suppressed sequence

    Description
    NM_206877.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center