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SPDYA speedy/RINGO cell cycle regulator family member A [ Homo sapiens (human) ]

Gene ID: 245711, updated on 11-Sep-2019

Summary

Official Symbol
SPDYAprovided by HGNC
Official Full Name
speedy/RINGO cell cycle regulator family member Aprovided by HGNC
Primary source
HGNC:HGNC:30613
See related
Ensembl:ENSG00000163806 MIM:614029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPY1; SPDY1; RINGO3; RINGOA
Expression
Biased expression in testis (RPKM 22.5), duodenum (RPKM 1.7) and 10 other tissues See more
Orthologs

Genomic context

See SPDYA in Genome Data Viewer
Location:
2p23.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (28810834..28850610)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (29033462..29073476)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505774 Neighboring gene uncharacterized LOC112267877 Neighboring gene protein phosphatase 1 catalytic subunit beta Neighboring gene tRNA methyltransferase 61B Neighboring gene WD repeat domain 43 Neighboring gene small nucleolar RNA, C/D box 92 Neighboring gene small nucleolar RNA, C/D box 53

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PPP1CB

Homology

Clone Names

  • MGC57218, MGC110856

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
male meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
speedy protein A
Names
RINGO A
epididymis secretory sperm binding protein
hSpy/Ringo A
rapid inducer of G2/M progression in oocytes A
speedy homolog A
speedy-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008779.1NP_001008779.1  speedy protein A isoform 2

    See identical proteins and their annotated locations for NP_001008779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks some 5' UTR sequence and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AA625975, AY820303, BC047224
    UniProtKB/Swiss-Prot
    Q5MJ70
    Conserved Domains (1) summary
    pfam11357
    Location:69199
    Spy1; Cell cycle regulatory protein
  2. NM_001142634.2NP_001136106.1  speedy protein A isoform 1

    See identical proteins and their annotated locations for NP_001136106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 both encode the longer protein (isoform 1).
    Source sequence(s)
    AY820304, BC047224, BC093005
    Consensus CDS
    CCDS1767.2
    UniProtKB/Swiss-Prot
    Q5MJ70
    Related
    ENSP00000368898.4, ENST00000379579.8
    Conserved Domains (1) summary
    pfam11357
    Location:69199
    Spy1; Cell cycle regulatory protein
  3. NM_182756.4NP_877433.2  speedy protein A isoform 1

    See identical proteins and their annotated locations for NP_877433.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks a segment in the 5' UTR, compared to variant 3. Variants 1 and 3 both encode the longer protein (isoform 1).
    Source sequence(s)
    AY820304, BC047224, BC093005
    Consensus CDS
    CCDS1767.2
    UniProtKB/Swiss-Prot
    Q5MJ70
    Related
    ENSP00000335628.5, ENST00000334056.10
    Conserved Domains (1) summary
    pfam11357
    Location:69199
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    28810834..28850610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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