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ZSCAN32 zinc finger and SCAN domain containing 32 [ Homo sapiens (human) ]

Gene ID: 54925, updated on 5-Jan-2022

Summary

Official Symbol
ZSCAN32provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 32provided by HGNC
Primary source
HGNC:HGNC:20812
See related
Ensembl:ENSG00000140987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCCS-5; ZNF434
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in testis (RPKM 4.7), lymph node (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZSCAN32 in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3382085..3402007, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3432085..3451004, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-RNR2 like 4 (pseudogene) Neighboring gene MT-ND1 pseudogene 8 Neighboring gene zinc finger protein 174 Neighboring gene zinc finger protein 597 Neighboring gene N-alpha-acetyltransferase 60, NatF catalytic subunit Neighboring gene microRNA 6126

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4179, FLJ20417, FLJ31901, FLJ56278

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 32
Names
human cervical cancer suppressor gene 5 protein
zinc finger protein 434

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284527.2NP_001271456.1  zinc finger and SCAN domain-containing protein 32 isoform a

    See identical proteins and their annotated locations for NP_001271456.1

    Status: VALIDATED

    Source sequence(s)
    AK291213, AY261676
    Consensus CDS
    CCDS66921.1
    UniProtKB/Swiss-Prot
    Q9NX65
    Related
    ENSP00000380061.4, ENST00000396852.9
    Conserved Domains (8) summary
    smart00431
    Location:33142
    SCAN; leucine rich region
    COG5048
    Location:455668
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:522543
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:33121
    SCAN; SCAN domain
    pfam13465
    Location:591616
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:253334
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:218250
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. NM_001284528.2NP_001271457.1  zinc finger and SCAN domain-containing protein 32 isoform c

    See identical proteins and their annotated locations for NP_001271457.1

    Status: VALIDATED

    Source sequence(s)
    AK056463, AK291213, AY261676
    Consensus CDS
    CCDS66920.1
    UniProtKB/Swiss-Prot
    Q9NX65
    Related
    ENSP00000483210.1, ENST00000618425.4
    Conserved Domains (5) summary
    COG5048
    Location:230379
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:233254
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:302327
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:145
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
  3. NM_001284529.2NP_001271458.1  zinc finger and SCAN domain-containing protein 32 isoform c

    See identical proteins and their annotated locations for NP_001271458.1

    Status: VALIDATED

    Source sequence(s)
    AC025283, AK301586, AY261676
    Consensus CDS
    CCDS66920.1
    UniProtKB/Swiss-Prot
    Q9NX65
    Related
    ENSP00000391787.2, ENST00000439568.2
    Conserved Domains (5) summary
    COG5048
    Location:230379
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:233254
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:302327
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:145
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
  4. NM_001324340.2NP_001311269.1  zinc finger and SCAN domain-containing protein 32 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC025283
    Consensus CDS
    CCDS10503.1
    UniProtKB/Swiss-Prot
    Q9NX65
    Conserved Domains (6) summary
    COG5048
    Location:307456
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:310331
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:379404
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:41122
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:638
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  5. NM_001324341.2NP_001311270.1  zinc finger and SCAN domain-containing protein 32 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC025283
    Consensus CDS
    CCDS10503.1
    UniProtKB/Swiss-Prot
    Q9NX65
    Conserved Domains (6) summary
    COG5048
    Location:307456
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:310331
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:379404
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:41122
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:638
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  6. NM_001324342.2NP_001311271.1  zinc finger and SCAN domain-containing protein 32 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC025283
    Consensus CDS
    CCDS10503.1
    UniProtKB/Swiss-Prot
    Q9NX65
    Conserved Domains (6) summary
    COG5048
    Location:307456
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:310331
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:379404
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:41122
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:638
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  7. NM_001324343.2NP_001311272.1  zinc finger and SCAN domain-containing protein 32 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC025283
  8. NM_001324344.2NP_001311273.1  zinc finger and SCAN domain-containing protein 32 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC025283
    Consensus CDS
    CCDS10503.1
    UniProtKB/Swiss-Prot
    Q9NX65
    Conserved Domains (6) summary
    COG5048
    Location:307456
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:310331
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:379404
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:41122
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:638
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  9. NM_001324345.2NP_001311274.1  zinc finger and SCAN domain-containing protein 32 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC025283
    Consensus CDS
    CCDS10503.1
    UniProtKB/Swiss-Prot
    Q9NX65
    Conserved Domains (6) summary
    COG5048
    Location:307456
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:310331
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:379404
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:41122
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:638
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  10. NM_001324346.2NP_001311275.1  zinc finger and SCAN domain-containing protein 32 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC025283
    Conserved Domains (7) summary
    smart00431
    Location:33142
    SCAN; leucine rich region
    COG5048
    Location:382595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450470
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:449470
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:33121
    SCAN; SCAN domain
    pfam13465
    Location:518543
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:180261
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
  11. NM_017810.4NP_060280.2  zinc finger and SCAN domain-containing protein 32 isoform b

    See identical proteins and their annotated locations for NP_060280.2

    Status: VALIDATED

    Source sequence(s)
    AY261676
    Consensus CDS
    CCDS10503.1
    UniProtKB/Swiss-Prot
    Q9NX65
    Related
    ENSP00000302502.3, ENST00000304926.7
    Conserved Domains (6) summary
    COG5048
    Location:307456
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:310331
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:379404
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:41122
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:638
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3382085..3402007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023373.2XP_016878862.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    Conserved Domains (8) summary
    smart00431
    Location:33139
    SCAN; leucine rich region
    COG5048
    Location:368581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:435456
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:33121
    SCAN; SCAN domain
    pfam13465
    Location:504529
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:166247
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:131163
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. XM_017023371.2XP_016878860.1  zinc finger and SCAN domain-containing protein 32 isoform X1

    UniProtKB/Swiss-Prot
    Q9NX65
    Conserved Domains (8) summary
    smart00431
    Location:33142
    SCAN; leucine rich region
    COG5048
    Location:455668
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:522543
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:33121
    SCAN; SCAN domain
    pfam13465
    Location:591616
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:253334
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:218250
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  3. XM_005255403.2XP_005255460.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    Conserved Domains (8) summary
    smart00431
    Location:33139
    SCAN; leucine rich region
    COG5048
    Location:368581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:435456
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:33121
    SCAN; SCAN domain
    pfam13465
    Location:504529
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:166247
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:131163
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  4. XM_017023372.1XP_016878861.1  zinc finger and SCAN domain-containing protein 32 isoform X2

    Conserved Domains (8) summary
    smart00431
    Location:33139
    SCAN; leucine rich region
    COG5048
    Location:368581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:435456
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:33121
    SCAN; SCAN domain
    pfam13465
    Location:504529
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:166247
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:131163
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  5. XM_011522555.2XP_011520857.1  zinc finger and SCAN domain-containing protein 32 isoform X1

    See identical proteins and their annotated locations for XP_011520857.1

    UniProtKB/Swiss-Prot
    Q9NX65
    Conserved Domains (8) summary
    smart00431
    Location:33142
    SCAN; leucine rich region
    COG5048
    Location:455668
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:522543
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:33121
    SCAN; SCAN domain
    pfam13465
    Location:591616
    zf-H2C2_2; Zinc-finger double domain
    pfam13837
    Location:253334
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
    cl02581
    Location:218250
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
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