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PXK PX domain containing serine/threonine kinase like [ Homo sapiens (human) ]

Gene ID: 54899, updated on 13-Mar-2020

Summary

Official Symbol
PXKprovided by HGNC
Official Full Name
PX domain containing serine/threonine kinase likeprovided by HGNC
Primary source
HGNC:HGNC:23326
See related
Ensembl:ENSG00000168297 MIM:611450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLOB; MONAKA
Summary
This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Broad expression in thyroid (RPKM 17.1), brain (RPKM 11.4) and 24 other tissues See more
Orthologs

Genomic context

See PXK in Genome Data Viewer
Location:
3p14.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (58332890..58426127)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (58318617..58411815)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 6, acylglycerol lipase Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene uncharacterized LOC105377106 Neighboring gene pyruvate dehydrogenase E1 subunit beta Neighboring gene uncharacterized LOC107986092

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
NHGRI GWA Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
actin binding IEA
Inferred from Electronic Annotation
more info
 
NOT nucleotide binding NAS
Non-traceable Author Statement
more info
PubMed 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
NOT protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation of chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PX domain-containing protein kinase-like protein
Names
PX ser/thr kinase v2
PX serine/threonine kinase
modulator of Na,K-ATPase long form

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289095.1NP_001276024.1  PX domain-containing protein kinase-like protein isoform b

    See identical proteins and their annotated locations for NP_001276024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and contains an alternate exon in the 3' coding region, compared to variant 1. This results in a frameshift and an early stop codon, compared to variant 1. It encodes isoform b (also known as isoform 2), which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK131385, AL137938, AY437879, DA296189
    Consensus CDS
    CCDS74954.1
    UniProtKB/Swiss-Prot
    Q7Z7A4
    UniProtKB/TrEMBL
    A0A0C4DG95
    Related
    ENSP00000419049.1, ENST00000479241.5
    Conserved Domains (2) summary
    cd00180
    Location:181328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. NM_001289096.1NP_001276025.1  PX domain-containing protein kinase-like protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive, alternate, in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform c (also known as isoform 3), which is shorter than isoform a.
    Source sequence(s)
    AL137938, AY274811, AY437879, BG613223, DA296189
    UniProtKB/Swiss-Prot
    Q7Z7A4
    Conserved Domains (2) summary
    cd00180
    Location:165312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1399
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  3. NM_001289098.1NP_001276027.1  PX domain-containing protein kinase-like protein isoform d

    See identical proteins and their annotated locations for NP_001276027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' region, resulting in an early stop codon, compared to variant 1. It encodes isoform d (also known as isoform 4), which is shorter and has a distinct C-terminus, compared to isoform a. Variants 4 and 8 both encode the same isoform (d).
    Source sequence(s)
    AK131385, AK296034, AL137938, DQ124708, HY164612
    Consensus CDS
    CCDS74952.1
    UniProtKB/Swiss-Prot
    Q7Z7A4
    UniProtKB/TrEMBL
    B4DJD8
    Related
    ENSP00000373222.4, ENST00000383716.7
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  4. NM_001289099.1NP_001276028.1  PX domain-containing protein kinase-like protein isoform e

    See identical proteins and their annotated locations for NP_001276028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform e (also known as isoform 5), which has a shorter N-terminus, compared to isoform a. Variants 5 and 9 both encode the same isoform (e).
    Source sequence(s)
    AK131385, AL137938, AY847220, HY164612
    UniProtKB/Swiss-Prot
    Q7Z7A4
    Conserved Domains (3) summary
    COG0515
    Location:103409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  5. NM_001289100.1NP_001276029.1  PX domain-containing protein kinase-like protein isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two consecutive, alternate, in-frame exons in the 5' coding region and contains an alternate exon in the 3' region, resulting in an early stop codon, compared to variant 1. It encodes isoform f (also known as isoform 6), which is shorter and has a distinct C-terminus, compared to isoform a. Variants 6 and 10 both encode the same isoform (f).
    Source sequence(s)
    AK295542, AK296034, AL137938, AY274811, DA296189
    Consensus CDS
    CCDS74955.1
    UniProtKB/Swiss-Prot
    Q7Z7A4
    UniProtKB/TrEMBL
    B4DID9, B4DJD8, E9PD56
    Related
    ENSP00000417903.1, ENST00000463280.5
    Conserved Domains (3) summary
    COG0515
    Location:153459
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:165312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1399
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  6. NM_001289101.1NP_001276030.1  PX domain-containing protein kinase-like protein isoform g

    See identical proteins and their annotated locations for NP_001276030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform g (also known as isoform 7), which is shorter at the N-terminus, compared to isoform a. Variants 7 and 11 both encode the same isoform (g).
    Source sequence(s)
    AK131385, AK296215, AL137938, AY274811, DA296189
    UniProtKB/Swiss-Prot
    Q7Z7A4
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (2) summary
    COG0515
    Location:49355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  7. NM_001349488.1NP_001336417.1  PX domain-containing protein kinase-like protein isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 4, encodes isoform d.
    Source sequence(s)
    AC098479, AC135507
    Consensus CDS
    CCDS74952.1
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  8. NM_001349489.1NP_001336418.1  PX domain-containing protein kinase-like protein isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 5, encodes isoform e.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:103409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  9. NM_001349490.1NP_001336419.1  PX domain-containing protein kinase-like protein isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 6, encodes isoform f.
    Source sequence(s)
    AC098479, AC135507
    Consensus CDS
    CCDS74955.1
    Conserved Domains (3) summary
    COG0515
    Location:153459
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:165312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1399
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  10. NM_001349491.1NP_001336420.1  PX domain-containing protein kinase-like protein isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 7, encodes isoform g.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    COG0515
    Location:49355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  11. NM_001349492.1NP_001336421.1  PX domain-containing protein kinase-like protein isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) encodes the longest isoform (h).
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  12. NM_001349493.1NP_001336422.1  PX domain-containing protein kinase-like protein isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) encodes isoform i.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  13. NM_001349494.1NP_001336423.1  PX domain-containing protein kinase-like protein isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) encodes isoform j.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:170476
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:182329
    PKc; Catalytic domain of Protein Kinases
  14. NM_001349495.1NP_001336424.1  PX domain-containing protein kinase-like protein isoform k

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) encodes isoform k.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd06871
    Location:13116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:182329
    PKc; Catalytic domain of Protein Kinases
  15. NM_001349496.1NP_001336425.1  PX domain-containing protein kinase-like protein isoform jj

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) encodes isoform jj.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:169475
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:181328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  16. NM_001349497.1NP_001336426.1  PX domain-containing protein kinase-like protein isoform l

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) encodes isoform l.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd00180
    Location:181328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  17. NM_001349498.1NP_001336427.1  PX domain-containing protein kinase-like protein isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) encodes isoform m.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:15112
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:166472
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:178325
    PKc; Catalytic domain of Protein Kinases
  18. NM_001349499.1NP_001336428.1  PX domain-containing protein kinase-like protein isoform n

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) encodes isoform n.
    Source sequence(s)
    AC098479, AC135507
    Consensus CDS
    CCDS87097.1
    Related
    ENSP00000305045.6, ENST00000302779.9
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186526
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  19. NM_001349500.1NP_001336429.1  PX domain-containing protein kinase-like protein isoform o

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) encodes isoform o.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd00180
    Location:165312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1399
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  20. NM_001349501.1NP_001336430.1  PX domain-containing protein kinase-like protein isoform p

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) encodes isoform p.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:170510
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:182329
    PKc; Catalytic domain of Protein Kinases
  21. NM_001349502.1NP_001336431.1  PX domain-containing protein kinase-like protein isoform q

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) encodes isoform q.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:169509
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:181328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  22. NM_001349503.1NP_001336432.1  PX domain-containing protein kinase-like protein isoform r

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variant 26, encodes isoform r.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  23. NM_001349504.1NP_001336433.1  PX domain-containing protein kinase-like protein isoform kk

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variant 25, encodes isoform kk.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  24. NM_001349506.1NP_001336435.1  PX domain-containing protein kinase-like protein isoform kk

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variant 24, encodes isoform kk.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  25. NM_001349507.1NP_001336436.1  PX domain-containing protein kinase-like protein isoform r

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26), as well as variant 23, encodes isoform r.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  26. NM_001349508.1NP_001336437.1  PX domain-containing protein kinase-like protein isoform s

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27), as well as variant 28, encodes isoform s.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  27. NM_001349509.1NP_001336438.1  PX domain-containing protein kinase-like protein isoform s

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28), as well as variant 27, encodes isoform s.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  28. NM_001349510.1NP_001336439.1  PX domain-containing protein kinase-like protein isoform t

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29) encodes isoform t.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:170476
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:182329
    PKc; Catalytic domain of Protein Kinases
  29. NM_001349511.1NP_001336440.1  PX domain-containing protein kinase-like protein isoform u

    Status: VALIDATED

    Description
    Transcript Variant: This variant (30) encodes isoform u.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd06871
    Location:13116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:182329
    PKc; Catalytic domain of Protein Kinases
  30. NM_001349512.1NP_001336441.1  PX domain-containing protein kinase-like protein isoform ll

    Status: VALIDATED

    Description
    Transcript Variant: This variant (31) encodes isoform ll.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:170476
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:182329
    PKc; Catalytic domain of Protein Kinases
  31. NM_001349513.1NP_001336442.1  PX domain-containing protein kinase-like protein isoform mm

    Status: VALIDATED

    Description
    Transcript Variant: This variant (32) encodes isoform mm.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:103409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  32. NM_001349514.1NP_001336443.1  PX domain-containing protein kinase-like protein isoform nn

    Status: VALIDATED

    Description
    Transcript Variant: This variant (33) encodes isoform nn.
    Source sequence(s)
    AC098479, AC135507
    Consensus CDS
    CCDS87098.1
    Related
    ENSP00000373221.4, ENST00000383715.8
    Conserved Domains (3) summary
    COG0515
    Location:169475
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:181328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  33. NM_001349515.1NP_001336444.1  PX domain-containing protein kinase-like protein isoform v

    Status: VALIDATED

    Description
    Transcript Variant: This variant (34) encodes isoform v.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd00180
    Location:181328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  34. NM_001349516.1NP_001336445.1  PX domain-containing protein kinase-like protein isoform oo

    Status: VALIDATED

    Description
    Transcript Variant: This variant (35) encodes isoform oo.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd06871
    Location:13116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:182329
    PKc; Catalytic domain of Protein Kinases
  35. NM_001349517.1NP_001336446.1  PX domain-containing protein kinase-like protein isoform pp

    Status: VALIDATED

    Description
    Transcript Variant: This variant (36) encodes isoform pp.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:169475
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:181328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  36. NM_001349518.1NP_001336447.1  PX domain-containing protein kinase-like protein isoform w

    Status: VALIDATED

    Description
    Transcript Variant: This variant (37) encodes isoform w.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd00180
    Location:181328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  37. NM_001349519.1NP_001336448.1  PX domain-containing protein kinase-like protein isoform x

    Status: VALIDATED

    Description
    Transcript Variant: This variant (38), as well as variant 39, encodes isoform x.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186493
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  38. NM_001349520.1NP_001336449.1  PX domain-containing protein kinase-like protein isoform x

    Status: VALIDATED

    Description
    Transcript Variant: This variant (39), as well as variant 38, encodes isoform x.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186493
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  39. NM_001349521.1NP_001336450.1  PX domain-containing protein kinase-like protein isoform qq

    Status: VALIDATED

    Description
    Transcript Variant: This variant (40) encodes isoform qq.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd00180
    Location:115262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  40. NM_001349522.1NP_001336451.1  PX domain-containing protein kinase-like protein isoform y

    Status: VALIDATED

    Description
    Transcript Variant: This variant (41) encodes isoform y.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:153459
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:165312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1399
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  41. NM_001349524.1NP_001336453.1  PX domain-containing protein kinase-like protein isoform z

    Status: VALIDATED

    Description
    Transcript Variant: This variant (42) encodes isoform z.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd00180
    Location:165312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1399
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  42. NM_001349525.1NP_001336454.1  PX domain-containing protein kinase-like protein isoform aa

    Status: VALIDATED

    Description
    Transcript Variant: This variant (43) encodes isoform aa.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    COG0515
    Location:49355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  43. NM_001349526.1NP_001336455.1  PX domain-containing protein kinase-like protein isoform bb

    Status: VALIDATED

    Description
    Transcript Variant: This variant (44) encodes isoform bb.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (1) summary
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  44. NM_001349527.1NP_001336456.1  PX domain-containing protein kinase-like protein isoform cc

    Status: VALIDATED

    Description
    Transcript Variant: This variant (45) encodes isoform cc.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  45. NM_001349528.1NP_001336457.1  PX domain-containing protein kinase-like protein isoform dd

    Status: VALIDATED

    Description
    Transcript Variant: This variant (46), as well as variant 47, encodes isoform dd.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:103409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  46. NM_001349529.1NP_001336458.1  PX domain-containing protein kinase-like protein isoform dd

    Status: VALIDATED

    Description
    Transcript Variant: This variant (47), as well as variant 46, encodes isoform dd.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:103409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  47. NM_001349530.1NP_001336459.1  PX domain-containing protein kinase-like protein isoform ee

    Status: VALIDATED

    Description
    Transcript Variant: This variant (48) encodes isoform ee.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd00180
    Location:115262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  48. NM_001349531.1NP_001336460.1  PX domain-containing protein kinase-like protein isoform rr

    Status: VALIDATED

    Description
    Transcript Variant: This variant (49) encodes isoform rr.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:103409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  49. NM_001349532.1NP_001336461.1  PX domain-containing protein kinase-like protein isoform ff

    Status: VALIDATED

    Description
    Transcript Variant: This variant (50) encodes isoform ff.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    COG0515
    Location:49389
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  50. NM_001349533.1NP_001336462.1  PX domain-containing protein kinase-like protein isoform gg

    Status: VALIDATED

    Description
    Transcript Variant: This variant (51), as well as variant 52, encodes isoform gg.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    COG0515
    Location:49355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  51. NM_001349534.1NP_001336463.1  PX domain-containing protein kinase-like protein isoform gg

    Status: VALIDATED

    Description
    Transcript Variant: This variant (52), as well as variant 51, encodes isoform gg.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    COG0515
    Location:49355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  52. NM_001349535.1NP_001336464.1  PX domain-containing protein kinase-like protein isoform hh

    Status: VALIDATED

    Description
    Transcript Variant: This variant (53), as well as variant 54, encodes isoform hh.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    COG0515
    Location:49355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  53. NM_001349536.1NP_001336465.1  PX domain-containing protein kinase-like protein isoform hh

    Status: VALIDATED

    Description
    Transcript Variant: This variant (54), as well as variant 53, encodes isoform hh.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    COG0515
    Location:49355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  54. NM_001349537.1NP_001336466.1  PX domain-containing protein kinase-like protein isoform ss

    Status: VALIDATED

    Description
    Transcript Variant: This variant (55), as well as variant 56, encodes isoform ss.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (1) summary
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  55. NM_001349538.1NP_001336467.1  PX domain-containing protein kinase-like protein isoform ss

    Status: VALIDATED

    Description
    Transcript Variant: This variant (56), as well as variant 55, encodes isoform ss.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (1) summary
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  56. NM_001349539.1NP_001336468.1  PX domain-containing protein kinase-like protein isoform ii

    Status: VALIDATED

    Description
    Transcript Variant: This variant (57), as well as variant 58, encodes isoform ii.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (1) summary
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  57. NM_001349540.1NP_001336469.1  PX domain-containing protein kinase-like protein isoform ii

    Status: VALIDATED

    Description
    Transcript Variant: This variant (58), as well as variant 57, encodes isoform ii.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (1) summary
    cd00180
    Location:61208
    PKc; Catalytic domain of Protein Kinases
  58. NM_017771.5NP_060241.2  PX domain-containing protein kinase-like protein isoform a

    See identical proteins and their annotated locations for NP_060241.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a (also known as isoform 1).
    Source sequence(s)
    AK296034, AL137938, AY274811, DQ124707, DQ124708, HY164612
    Consensus CDS
    CCDS2889.1
    UniProtKB/Swiss-Prot
    Q7Z7A4
    UniProtKB/TrEMBL
    B4DJD8
    Related
    ENSP00000348472.2, ENST00000356151.7
    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases

RNA

  1. NR_146193.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098479, AC135507
  2. NR_146194.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098479, AC135507

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    58332890..58426127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265250.4XP_005265307.1  PX domain-containing protein kinase-like protein isoform X1

    See identical proteins and their annotated locations for XP_005265307.1

    UniProtKB/TrEMBL
    W5RX72
    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  2. XM_017006678.1XP_016862167.1  PX domain-containing protein kinase-like protein isoform X2

    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  3. XM_017006683.1XP_016862172.1  PX domain-containing protein kinase-like protein isoform X3

    Conserved Domains (2) summary
    cd00180
    Location:181328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
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