U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pxk PX domain containing serine/threonine kinase [ Mus musculus (house mouse) ]

Gene ID: 218699, updated on 5-Jan-2023

Summary

Official Symbol
Pxkprovided by MGI
Official Full Name
PX domain containing serine/threonine kinaseprovided by MGI
Primary source
MGI:MGI:1289230
See related
Ensembl:ENSMUSG00000033885 AllianceGenome:MGI:1289230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slob; Monaka; D14Ertd813e; C230080L11Rik
Summary
Enables protein C-terminus binding activity. Involved in negative regulation of ATPase activity and negative regulation of ion transport. Acts upstream of or within modulation of chemical synaptic transmission. Located in cytoplasm and plasma membrane. Part of protein-containing complex. Is expressed in brain and spinal cord. Orthologous to human PXK (PX domain containing serine/threonine kinase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 18.0), placenta adult (RPKM 17.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pxk in Genome Data Viewer
Location:
14 A1; 14 4.7 cM
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14304656..14371593, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (8098180..8165117)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53823 Neighboring gene pyruvate dehydrogenase (lipoamide) beta Neighboring gene ribosomal protein L13 pseudogene Neighboring gene ribonuclease P 14 subunit Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene abhydrolase domain containing 6 Neighboring gene predicted gene, 30244

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extrinsic component of endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PX domain-containing protein kinase-like protein
Names
modulator of Na,K-ATPase

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360313.1NP_001347242.1  PX domain-containing protein kinase-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK150660, AK153067, AW455875
    Consensus CDS
    CCDS88565.1
    UniProtKB/TrEMBL
    A0A2C9F2B5
    Related
    ENSMUSP00000035265.9, ENSMUST00000036682.9
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186482
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  2. NM_001360314.1NP_001347243.1  PX domain-containing protein kinase-like protein short isoform

    Status: VALIDATED

    Source sequence(s)
    AK150337, AK150660, AK153067, AW455875, CT573024
    Consensus CDS
    CCDS36799.1
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  3. NM_001360315.1NP_001347244.1  PX domain-containing protein kinase-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK150660, AK153067, AW455875, BM945330, CT573024
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186482
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  4. NM_001360316.1NP_001347245.1  PX domain-containing protein kinase-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK150337, AK150660, AK153067, AW455875, CT573024
  5. NM_145458.4NP_663433.2  PX domain-containing protein kinase-like protein long isoform

    See identical proteins and their annotated locations for NP_663433.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (L) encodes the longest isoform.
    Source sequence(s)
    AK150337, AK150660, AK153067, AW455875
    Consensus CDS
    CCDS26810.1
    UniProtKB/Swiss-Prot
    Q8BX57, Q91WB6
    Related
    ENSMUSP00000152987.2, ENSMUST00000225653.2
    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  6. NM_178279.3NP_840063.1  PX domain-containing protein kinase-like protein short isoform

    See identical proteins and their annotated locations for NP_840063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (S) uses an alternate splice site in the 3' coding region, compared to variant L. The resulting protein is shorter and has a distinct C-terminus, when compared to the longer isoform.
    Source sequence(s)
    AK150660, AK153067, AW455875, BM945330, CT573024
    Consensus CDS
    CCDS36799.1
    UniProtKB/Swiss-Prot
    Q8BX57
    Related
    ENSMUSP00000108309.3, ENSMUST00000112689.9
    Conserved Domains (3) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    14304656..14371593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517982.3XP_006518045.1  PX domain-containing protein kinase-like protein isoform X7

    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  2. XM_006517977.4XP_006518040.1  PX domain-containing protein kinase-like protein isoform X2

    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  3. XM_030247724.1XP_030103584.1  PX domain-containing protein kinase-like protein isoform X5

    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  4. XM_006517980.3XP_006518043.1  PX domain-containing protein kinase-like protein isoform X6

    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  5. XM_006517975.4XP_006518038.1  PX domain-containing protein kinase-like protein isoform X1

    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  6. XM_006517978.4XP_006518041.1  PX domain-containing protein kinase-like protein isoform X4

    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  7. XM_036158542.1XP_036014435.1  PX domain-containing protein kinase-like protein isoform X9

    Conserved Domains (3) summary
    cd22062
    Location:465495
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115262
    PKc_like; Protein Kinases, catalytic domain
  8. XM_036158540.1XP_036014433.1  PX domain-containing protein kinase-like protein isoform X8

    Conserved Domains (3) summary
    cd22062
    Location:466496
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115262
    PKc_like; Protein Kinases, catalytic domain
  9. XM_036158541.1XP_036014434.1  PX domain-containing protein kinase-like protein isoform X8

    Conserved Domains (3) summary
    cd22062
    Location:466496
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115262
    PKc_like; Protein Kinases, catalytic domain
  10. XM_030247727.1XP_030103587.1  PX domain-containing protein kinase-like protein isoform X9

    Conserved Domains (3) summary
    cd22062
    Location:465495
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115262
    PKc_like; Protein Kinases, catalytic domain
  11. XM_030247728.1XP_030103588.1  PX domain-containing protein kinase-like protein isoform X10

    Conserved Domains (2) summary
    cd00180
    Location:115262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  12. XM_006517984.2XP_006518047.1  PX domain-containing protein kinase-like protein isoform X8

    See identical proteins and their annotated locations for XP_006518047.1

    Conserved Domains (3) summary
    cd22062
    Location:466496
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115262
    PKc_like; Protein Kinases, catalytic domain
  13. XM_030247726.1XP_030103586.1  PX domain-containing protein kinase-like protein isoform X9

    Conserved Domains (3) summary
    cd22062
    Location:465495
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115262
    PKc_like; Protein Kinases, catalytic domain
  14. XM_006517985.2XP_006518048.1  PX domain-containing protein kinase-like protein isoform X8

    See identical proteins and their annotated locations for XP_006518048.1

    Conserved Domains (3) summary
    cd22062
    Location:466496
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:149
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115262
    PKc_like; Protein Kinases, catalytic domain
  15. XM_017315951.2XP_017171440.1  PX domain-containing protein kinase-like protein isoform X6

    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases
  16. XM_017315949.2XP_017171438.1  PX domain-containing protein kinase-like protein isoform X3

    Conserved Domains (2) summary
    cd06871
    Location:13132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198345
    PKc; Catalytic domain of Protein Kinases

RNA

  1. XR_874027.3 RNA Sequence

  2. XR_001781106.2 RNA Sequence

  3. XR_004938378.1 RNA Sequence