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CWC25 CWC25 spliceosome associated protein homolog [ Homo sapiens (human) ]

Gene ID: 54883, updated on 7-Jun-2020

Summary

Official Symbol
CWC25provided by HGNC
Official Full Name
CWC25 spliceosome associated protein homologprovided by HGNC
Primary source
HGNC:HGNC:25989
See related
Ensembl:ENSG00000273559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC49
Summary
This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 26.7), testis (RPKM 10.6) and 24 other tissues See more
Orthologs

Genomic context

See CWC25 in Genome Data Viewer
Location:
17q12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (38800434..38825350, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36956687..36981603, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 866, pseudogene Neighboring gene proteasome 20S subunit beta 3 Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 beta Neighboring gene microRNA 4727 Neighboring gene chromosome 17 open reading frame 98

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20291, DKFZp779M0968

Gene Ontology Provided by GOA

Process Evidence Code Pubs
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
U2-type catalytic step 1 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pre-mRNA-splicing factor CWC25 homolog
Names
coiled-coil domain-containing protein 49

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017748.5NP_060218.1  pre-mRNA-splicing factor CWC25 homolog

    See identical proteins and their annotated locations for NP_060218.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the supported protein.
    Source sequence(s)
    AC006449, AW612704, BC008833
    Consensus CDS
    CCDS45663.1
    UniProtKB/Swiss-Prot
    Q9NXE8
    Related
    ENSP00000478070.1, ENST00000614790.5
    Conserved Domains (2) summary
    pfam10197
    Location:1137
    Cir_N; N-terminal domain of CBF1 interacting co-repressor CIR
    pfam12542
    Location:67156
    CWC25; Pre-mRNA splicing factor

RNA

  1. NR_073428.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC006449, AK296115, AW612704, HY021361

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    38800434..38825350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001752548.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2835753..2860669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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