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Cwc25 CWC25 spliceosome-associated protein [ Mus musculus (house mouse) ]

Gene ID: 67480, updated on 26-Sep-2022


Official Symbol
Cwc25provided by MGI
Official Full Name
CWC25 spliceosome-associated proteinprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000018541 AllianceGenome:MGI:1914730
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc49; 1300013D05Rik
Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome. Is expressed in dermis and epidermis. Orthologous to human CWC25 (CWC25 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in CNS E11.5 (RPKM 7.3), limb E14.5 (RPKM 5.5) and 28 other tissues See more
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Genomic context

See Cwc25 in Genome Data Viewer
11; 11 D
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97636296..97657439, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97745470..97766613, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, beta Neighboring gene microRNA 8102 Neighboring gene ATP synthase, H+ transporting, mitochondrial FO complex, subunit G2, pseudogene Neighboring gene nuclear encoded tRNA cysteine 18 (anticodon GCA)

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC90568

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
part_of U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
located_in nucleus ISO
Inferred from Sequence Orthology
more info
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
pre-mRNA-splicing factor CWC25 homolog
CWC25 spliceosome-associated protein homolog
coiled-coil domain containing 49
coiled-coil domain-containing protein 49
spliceosome-associated protein homolog CWC25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026186.4NP_080462.2  pre-mRNA-splicing factor CWC25 homolog

    See identical proteins and their annotated locations for NP_080462.2

    Status: VALIDATED

    Source sequence(s)
    AK004983, BC053447, BY307671, BY488530
    Consensus CDS
    Q7TSF8, Q9DBF7
    ENSMUSP00000018685.3, ENSMUST00000018685.9
    Conserved Domains (2) summary
    Cir_N; N-terminal domain of CBF1 interacting co-repressor CIR
    CWC25; Pre-mRNA splicing factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000077.7 Reference GRCm39 C57BL/6J

    97636296..97657439 complement
    GenBank, FASTA, Sequence Viewer (Graphics)