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ZNF280D zinc finger protein 280D [ Homo sapiens (human) ]

Gene ID: 54816, updated on 1-Jun-2020

Summary

Official Symbol
ZNF280Dprovided by HGNC
Official Full Name
zinc finger protein 280Dprovided by HGNC
Primary source
HGNC:HGNC:25953
See related
Ensembl:ENSG00000137871 Ensembl:ENSG00000285253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUHW4; ZNF634
Expression
Ubiquitous expression in ovary (RPKM 5.7), endometrium (RPKM 5.4) and 25 other tissues See more
Orthologs

Genomic context

See ZNF280D in Genome Data Viewer
Location:
15q21.3
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (56630176..56734086, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (56922374..57026279, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370831 Neighboring gene uncharacterized LOC105370832 Neighboring gene acyl-CoA binding domain containing 7 pseudogene Neighboring gene uncharacterized LOC105370833 Neighboring gene uncharacterized LOC145783

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC21637, MGC61687

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 280D
Names
suppressor of hairy wing homolog 4
zinc finger protein 634

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002843.2NP_001002843.1  zinc finger protein 280D isoform 2

    See identical proteins and their annotated locations for NP_001002843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the first coding region used by variant 1 and is predicted to initiate translation from an in-frame downstream AUG, compared to variant 1. Variant 2 encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB046804, AC090517, AC090518, BC040532
    Consensus CDS
    CCDS42041.1
    UniProtKB/Swiss-Prot
    Q6N043
    Related
    ENSP00000454111.1, ENST00000559237.5
    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  2. NM_001002844.2NP_001002844.1  zinc finger protein 280D isoform 3

    See identical proteins and their annotated locations for NP_001002844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks multiple 3' exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AC090517, AC090518, BC064359
    Consensus CDS
    CCDS58364.1
    UniProtKB/Swiss-Prot
    Q6N043
    Related
    ENSP00000453706.1, ENST00000558320.5
    Conserved Domains (1) summary
    pfam13836
    Location:45127
    DUF4195; Domain of unknown function (DUF4195)
  3. NM_001288588.1NP_001275517.1  zinc finger protein 280D isoform 1

    See identical proteins and their annotated locations for NP_001275517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC090517, AC090518, BC040532, BC136412
    Consensus CDS
    CCDS32245.1
    UniProtKB/Swiss-Prot
    Q6N043
    Conserved Domains (2) summary
    sd00017
    Location:360381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45229
    DUF4195; Domain of unknown function (DUF4195)
  4. NM_001288589.1NP_001275518.1  zinc finger protein 280D isoform 3

    See identical proteins and their annotated locations for NP_001275518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AC090517, AC090518, BC064359, CX788386
    Consensus CDS
    CCDS58364.1
    UniProtKB/Swiss-Prot
    Q6N043
    Conserved Domains (1) summary
    pfam13836
    Location:45127
    DUF4195; Domain of unknown function (DUF4195)
  5. NM_017661.3NP_060131.2  zinc finger protein 280D isoform 1

    See identical proteins and their annotated locations for NP_060131.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC090517, AC090518, BC040532, BC130451
    Consensus CDS
    CCDS32245.1
    UniProtKB/Swiss-Prot
    Q6N043
    Related
    ENSP00000267807.7, ENST00000267807.11
    Conserved Domains (2) summary
    sd00017
    Location:360381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45229
    DUF4195; Domain of unknown function (DUF4195)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    56630176..56734086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521701.1XP_011520003.1  zinc finger protein 280D isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  2. XM_011521702.1XP_011520004.1  zinc finger protein 280D isoform X3

    See identical proteins and their annotated locations for XP_011520004.1

    UniProtKB/Swiss-Prot
    Q6N043
    Conserved Domains (2) summary
    sd00017
    Location:360381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45229
    DUF4195; Domain of unknown function (DUF4195)
  3. XM_011521709.1XP_011520011.1  zinc finger protein 280D isoform X9

    See identical proteins and their annotated locations for XP_011520011.1

    Conserved Domains (2) summary
    sd00017
    Location:254275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:15123
    DUF4195; Domain of unknown function (DUF4195)
  4. XM_011521708.1XP_011520010.1  zinc finger protein 280D isoform X9

    See identical proteins and their annotated locations for XP_011520010.1

    Conserved Domains (2) summary
    sd00017
    Location:254275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:15123
    DUF4195; Domain of unknown function (DUF4195)
  5. XM_011521710.1XP_011520012.1  zinc finger protein 280D isoform X9

    See identical proteins and their annotated locations for XP_011520012.1

    Conserved Domains (2) summary
    sd00017
    Location:254275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:15123
    DUF4195; Domain of unknown function (DUF4195)
  6. XM_017022345.1XP_016877834.1  zinc finger protein 280D isoform X3

    UniProtKB/Swiss-Prot
    Q6N043
    Conserved Domains (2) summary
    sd00017
    Location:360381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45229
    DUF4195; Domain of unknown function (DUF4195)
  7. XM_017022344.1XP_016877833.1  zinc finger protein 280D isoform X3

    UniProtKB/Swiss-Prot
    Q6N043
    Conserved Domains (2) summary
    sd00017
    Location:360381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45229
    DUF4195; Domain of unknown function (DUF4195)
  8. XM_017022349.1XP_016877838.1  zinc finger protein 280D isoform X14

  9. XM_011521707.2XP_011520009.1  zinc finger protein 280D isoform X7

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  10. XM_011521704.2XP_011520006.1  zinc finger protein 280D isoform X4

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  11. XM_005254484.3XP_005254541.2  zinc finger protein 280D isoform X8

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  12. XM_017022346.1XP_016877835.1  zinc finger protein 280D isoform X5

  13. XM_005254481.3XP_005254538.2  zinc finger protein 280D isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  14. XM_017022347.2XP_016877836.1  zinc finger protein 280D isoform X11

  15. XM_005254483.3XP_005254540.2  zinc finger protein 280D isoform X6

    UniProtKB/TrEMBL
    H0YL38
    Related
    ENSP00000453045.1, ENST00000559000.6
    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  16. XM_017022348.1XP_016877837.1  zinc finger protein 280D isoform X12

  17. XM_011521711.1XP_011520013.1  zinc finger protein 280D isoform X10

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  18. XM_005254485.3XP_005254542.2  zinc finger protein 280D isoform X13

    Related
    ENSP00000453124.1, ENST00000558002.5
    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)

RNA

  1. XR_002957650.1 RNA Sequence

  2. XR_002957652.1 RNA Sequence

  3. XR_002957651.1 RNA Sequence

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