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ZNF280D zinc finger protein 280D [ Homo sapiens (human) ]

Gene ID: 54816, updated on 2-Dec-2022

Summary

Official Symbol
ZNF280Dprovided by HGNC
Official Full Name
zinc finger protein 280Dprovided by HGNC
Primary source
HGNC:HGNC:25953
See related
Ensembl:ENSG00000137871 AllianceGenome:HGNC:25953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUHW4; ZNF634
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 5.7), endometrium (RPKM 5.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF280D in Genome Data Viewer
Location:
15q21.3
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (56630176..56733509, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (54433301..54536640, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (56922374..57025707, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene testis expressed 9 Neighboring gene uncharacterized LOC105370832 Neighboring gene Sharpr-MPRA regulatory region 15328 Neighboring gene meiosis specific nuclear structural 1 Neighboring gene acyl-CoA binding domain containing 7 pseudogene Neighboring gene long intergenic non-protein coding RNA 3065 Neighboring gene TCF12 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC21637, MGC61687

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 280D
Names
suppressor of hairy wing homolog 4
zinc finger protein 634

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002843.3NP_001002843.1  zinc finger protein 280D isoform 2

    See identical proteins and their annotated locations for NP_001002843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the first coding region used by variant 1 and is predicted to initiate translation from an in-frame downstream AUG, compared to variant 1. Variant 2 encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB046804, AC090517, AC090518, BC040532
    Consensus CDS
    CCDS42041.1
    UniProtKB/Swiss-Prot
    Q6N043
    Related
    ENSP00000454111.1, ENST00000559237.5
    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  2. NM_001002844.3NP_001002844.1  zinc finger protein 280D isoform 3

    See identical proteins and their annotated locations for NP_001002844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks multiple 3' exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AC090517, AC090518, BC064359
    Consensus CDS
    CCDS58364.1
    UniProtKB/Swiss-Prot
    Q6N043
    Related
    ENSP00000453706.1, ENST00000558320.5
    Conserved Domains (1) summary
    pfam13836
    Location:45127
    DUF4195; Domain of unknown function (DUF4195)
  3. NM_001288588.2NP_001275517.1  zinc finger protein 280D isoform 1

    See identical proteins and their annotated locations for NP_001275517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC090518, BC040532, BC136412
    Consensus CDS
    CCDS32245.1
    UniProtKB/Swiss-Prot
    Q6N043, Q9NXS0
    Conserved Domains (2) summary
    sd00017
    Location:360381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45229
    DUF4195; Domain of unknown function (DUF4195)
  4. NM_001288589.2NP_001275518.1  zinc finger protein 280D isoform 3

    See identical proteins and their annotated locations for NP_001275518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AC090517, AC090518, BC064359, CX788386
    Consensus CDS
    CCDS58364.1
    UniProtKB/Swiss-Prot
    Q6N043
    Conserved Domains (1) summary
    pfam13836
    Location:45127
    DUF4195; Domain of unknown function (DUF4195)
  5. NM_017661.4NP_060131.2  zinc finger protein 280D isoform 1

    See identical proteins and their annotated locations for NP_060131.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC090518, BC040532, BC130451
    Consensus CDS
    CCDS32245.1
    UniProtKB/Swiss-Prot
    Q6N043, Q9NXS0
    Related
    ENSP00000267807.7, ENST00000267807.12
    Conserved Domains (2) summary
    sd00017
    Location:360381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45229
    DUF4195; Domain of unknown function (DUF4195)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    56630176..56733509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432726.1XP_047288682.1  zinc finger protein 280D isoform X4

  2. XM_011521701.2XP_011520003.1  zinc finger protein 280D isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  3. XM_047432725.1XP_047288681.1  zinc finger protein 280D isoform X2

  4. XM_047432724.1XP_047288680.1  zinc finger protein 280D isoform X1

    UniProtKB/Swiss-Prot
    Q9NXS0
  5. XM_011521702.2XP_011520004.1  zinc finger protein 280D isoform X1

    See identical proteins and their annotated locations for XP_011520004.1

    UniProtKB/Swiss-Prot
    Q6N043, Q9NXS0
    Conserved Domains (2) summary
    sd00017
    Location:360381
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:45229
    DUF4195; Domain of unknown function (DUF4195)
  6. XM_047432727.1XP_047288683.1  zinc finger protein 280D isoform X6

  7. XM_047432728.1XP_047288684.1  zinc finger protein 280D isoform X1

    UniProtKB/Swiss-Prot
    Q9NXS0
  8. XM_047432732.1XP_047288688.1  zinc finger protein 280D isoform X14

  9. XM_011521707.3XP_011520009.1  zinc finger protein 280D isoform X9

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  10. XM_047432729.1XP_047288685.1  zinc finger protein 280D isoform X10

  11. XM_011521704.3XP_011520006.1  zinc finger protein 280D isoform X7

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  12. XM_047432730.1XP_047288686.1  zinc finger protein 280D isoform X11

  13. XM_005254483.4XP_005254540.2  zinc finger protein 280D isoform X8

    UniProtKB/TrEMBL
    H0YL38
    Related
    ENSP00000453045.1, ENST00000559000.6
    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  14. XM_005254481.4XP_005254538.2  zinc finger protein 280D isoform X5

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  15. XM_011521711.2XP_011520013.1  zinc finger protein 280D isoform X12

    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)
  16. XM_047432731.1XP_047288687.1  zinc finger protein 280D isoform X13

  17. XM_005254485.4XP_005254542.2  zinc finger protein 280D isoform X15

    Related
    ENSP00000453124.1, ENST00000558002.5
    Conserved Domains (2) summary
    sd00017
    Location:347368
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:32216
    DUF4195; Domain of unknown function (DUF4195)

RNA

  1. XR_007064462.1 RNA Sequence

  2. XR_007064461.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    54433301..54536640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)