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TRIM44 tripartite motif containing 44 [ Homo sapiens (human) ]

Gene ID: 54765, updated on 5-Aug-2022

Summary

Official Symbol
TRIM44provided by HGNC
Official Full Name
tripartite motif containing 44provided by HGNC
Primary source
HGNC:HGNC:19016
See related
Ensembl:ENSG00000166326 MIM:612298; AllianceGenome:HGNC:19016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AN3; MC7; DIPB; HSA249128
Summary
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 26.6), thyroid (RPKM 23.0) and 25 other tissues See more
Orthologs
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Genomic context

See TRIM44 in Genome Data Viewer
Location:
11p13
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (35662775..35818007)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (35801539..35956748)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (35684323..35839557)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene four-jointed box kinase 1 Neighboring gene uncharacterized LOC124902661 Neighboring gene keratin 18 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Aniridia 3
MedGen: C4310695 OMIM: 617142 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genomewide association study of movement-related adverse antipsychotic effects.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 44 (TRIM44) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3490

General protein information

Preferred Names
tripartite motif-containing protein 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052784.1 RefSeqGene

    Range
    5061..153362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017583.6NP_060053.2  tripartite motif-containing protein 44

    See identical proteins and their annotated locations for NP_060053.2

    Status: REVIEWED

    Source sequence(s)
    AC090692, AK074242, BI222592, BI550863, BQ014398, CA445350, CX788887, CX871447, DA128342, DA131915, DA158251
    Consensus CDS
    CCDS31461.1
    UniProtKB/Swiss-Prot
    Q96DX7, Q9UGK0
    Related
    ENSP00000299413.5, ENST00000299413.7
    Conserved Domains (2) summary
    cd19784
    Location:177215
    Bbox2_TRIM44; B-box-type 2 zinc finger found in tripartite motif-containing protein 44 (TRIM44) and similar proteins
    cd19841
    Location:1560
    Bbox1_TRIM44; B-box-type 1 zinc finger found in tripartite motif-containing protein 44 (TRIM44) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    35662775..35818007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718254.2XP_006718317.1  tripartite motif-containing protein 44 isoform X1

    Conserved Domains (1) summary
    pfam00643
    Location:177215
    zf-B_box; B-box zinc finger

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    35801539..35956748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)