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ZNF853 zinc finger protein 853 [ Homo sapiens (human) ]

Gene ID: 54753, updated on 13-May-2022

Summary

Official Symbol
ZNF853provided by HGNC
Official Full Name
zinc finger protein 853provided by HGNC
Primary source
HGNC:HGNC:21767
See related
Ensembl:ENSG00000236609 AllianceGenome:HGNC:21767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 5.7), brain (RPKM 5.5) and 23 other tissues See more
Orthologs
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Genomic context

See ZNF853 in Genome Data Viewer
Location:
7p22.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6615610..6624290)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6734792..6743476)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6655241..6663921)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 4 Neighboring gene uncharacterized LOC124901582 Neighboring gene integrator complex subunit 15 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene Sharpr-MPRA regulatory region 15225 Neighboring gene zinc finger protein 316 Neighboring gene uncharacterized LOC124901583

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • DKFZp547K054, DKFZp434J1015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353546.2NP_001340475.1  zinc finger protein 853 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073343, BG056932
    Conserved Domains (2) summary
    COG5048
    Location:469600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_017560.3NP_060030.1  zinc finger protein 853 isoform 1

    See identical proteins and their annotated locations for NP_060030.1

    Status: VALIDATED

    Source sequence(s)
    AC073343, BG056932
    Consensus CDS
    CCDS59048.1
    UniProtKB/Swiss-Prot
    P0CG23
    Related
    ENSP00000455585.1, ENST00000457543.4
    Conserved Domains (3) summary
    COG5048
    Location:484615
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:515535
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:583608
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6615610..6624290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515439.4XP_011513741.1  zinc finger protein 853 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:522575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:526546
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:594619
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011515438.4XP_011513740.1  zinc finger protein 853 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:537590
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:541561
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:609634
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6734792..6743476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)