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POU6F1 POU class 6 homeobox 1 [ Homo sapiens (human) ]

Gene ID: 5463, updated on 4-Oct-2020

Summary

Official Symbol
POU6F1provided by HGNC
Official Full Name
POU class 6 homeobox 1provided by HGNC
Primary source
HGNC:HGNC:9224
See related
Ensembl:ENSG00000184271 MIM:618043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRN5; MPOU; TCFB1
Expression
Ubiquitous expression in brain (RPKM 4.7), ovary (RPKM 3.6) and 23 other tissues See more
Orthologs

Genomic context

See POU6F1 in Genome Data Viewer
Location:
12q13.13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (51186936..51219875, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51580719..51611477, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transcription factor CP2 Neighboring gene prohibitin pseudogene 19 Neighboring gene RNA, U6 small nuclear 199, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9853 Neighboring gene DAZ associated protein 2 Neighboring gene small cell adhesion glycoprotein Neighboring gene uncharacterized LOC102723983

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of POU class 6 homeobox 1 (POU6F1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
brain development TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heart development TAS
Traceable Author Statement
more info
PubMed 
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
POU domain, class 6, transcription factor 1
Names
brain-5
brain-specific homeobox/POU domain protein 5
mPOU homeobox protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330422.2NP_001317351.1  POU domain, class 6, transcription factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC139768
    Consensus CDS
    CCDS81691.1
    UniProtKB/Swiss-Prot
    Q14863
    UniProtKB/TrEMBL
    A0A1C7CYV8, B3KT91
    Related
    ENSP00000330190.11, ENST00000333640.11
  2. NM_001351088.2NP_001338017.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 12, encodes isoform 3.
    Source sequence(s)
    AC139768
  3. NM_001368008.1NP_001354937.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 4, encodes isoform 3.
    Source sequence(s)
    AC139768

RNA

  1. NR_026893.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139768
    Related
    ENST00000636728.1
  2. NR_147046.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  3. NR_147047.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  4. NR_147048.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  5. NR_147049.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  6. NR_147050.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  7. NR_147051.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  8. NR_147052.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  9. NR_160429.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  10. NR_160430.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    51186936..51219875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019510.2XP_016874999.1  POU domain, class 6, transcription factor 1 isoform X1

    Conserved Domains (3) summary
    smart00352
    Location:451525
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:549602
    Homeobox; Homeobox domain
    cl26464
    Location:41407
    Atrophin-1; Atrophin-1 family
  2. XM_024449026.1XP_024304794.1  POU domain, class 6, transcription factor 1 isoform X1

    Conserved Domains (3) summary
    smart00352
    Location:451525
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:549602
    Homeobox; Homeobox domain
    cl26464
    Location:41407
    Atrophin-1; Atrophin-1 family
  3. XM_017019529.1XP_016875018.1  POU domain, class 6, transcription factor 1 isoform X9

    UniProtKB/Swiss-Prot
    Q14863
    Conserved Domains (2) summary
    pfam00046
    Location:237290
    Homeobox; Homeobox domain
    cl22952
    Location:139213
    Pou; Pou domain - N-terminal to homeobox domain
  4. XM_017019508.1XP_016874997.1  POU domain, class 6, transcription factor 1 isoform X1

    Conserved Domains (3) summary
    smart00352
    Location:451525
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:549602
    Homeobox; Homeobox domain
    cl26464
    Location:41407
    Atrophin-1; Atrophin-1 family
  5. XM_017019516.1XP_016875005.1  POU domain, class 6, transcription factor 1 isoform X4

  6. XM_017019513.1XP_016875002.1  POU domain, class 6, transcription factor 1 isoform X2

  7. XM_024449027.1XP_024304795.1  POU domain, class 6, transcription factor 1 isoform X8

    Conserved Domains (1) summary
    cl26464
    Location:30366
    Atrophin-1; Atrophin-1 family
  8. XM_017019518.1XP_016875007.1  POU domain, class 6, transcription factor 1 isoform X6

  9. XM_017019517.1XP_016875006.1  POU domain, class 6, transcription factor 1 isoform X5

  10. XM_017019519.1XP_016875008.1  POU domain, class 6, transcription factor 1 isoform X7

  11. XM_017019514.1XP_016875003.1  POU domain, class 6, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A1C7CYV8
  12. XM_017019511.1XP_016875000.1  POU domain, class 6, transcription factor 1 isoform X1

    Conserved Domains (3) summary
    smart00352
    Location:451525
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:549602
    Homeobox; Homeobox domain
    cl26464
    Location:41407
    Atrophin-1; Atrophin-1 family
  13. XM_017019512.2XP_016875001.1  POU domain, class 6, transcription factor 1 isoform X1

    Conserved Domains (3) summary
    smart00352
    Location:451525
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:549602
    Homeobox; Homeobox domain
    cl26464
    Location:41407
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_001748774.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002702.3: Suppressed sequence

    Description
    NM_002702.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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