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POU6F1 POU class 6 homeobox 1 [ Homo sapiens (human) ]

Gene ID: 5463, updated on 3-Dec-2024

Summary

Official Symbol
POU6F1provided by HGNC
Official Full Name
POU class 6 homeobox 1provided by HGNC
Primary source
HGNC:HGNC:9224
See related
Ensembl:ENSG00000184271 MIM:618043; AllianceGenome:HGNC:9224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRN5; MPOU; TCFB1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in actin cytoskeleton and nuclear body. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 4.7), ovary (RPKM 3.6) and 23 other tissues See more
Orthologs
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Genomic context

See POU6F1 in Genome Data Viewer
Location:
12q13.13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (51186936..51218062, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (51149818..51180972, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51580719..51611846, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transcription factor CP2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6370 Neighboring gene RNA, U6 small nuclear 199, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51566351-51567098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6371 Neighboring gene uncharacterized LOC124902933 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51593597-51594096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6373 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:51614127-51614306 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51631660-51632297 Neighboring gene Sharpr-MPRA regulatory region 9853 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51633573-51634209 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51641233-51641734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51641735-51642234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51642235-51642736 Neighboring gene DAZ associated protein 2 Neighboring gene small cell adhesion glycoprotein Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51663873-51664373 Neighboring gene bridging integrator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6376 Neighboring gene Sharpr-MPRA regulatory region 8177 Neighboring gene uncharacterized LOC105369767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4466

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of POU class 6 homeobox 1 (POU6F1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
POU domain, class 6, transcription factor 1
Names
brain-5
brain-specific homeobox/POU domain protein 5
mPOU homeobox protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330422.2NP_001317351.1  POU domain, class 6, transcription factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC139768
    Consensus CDS
    CCDS81691.1
    UniProtKB/TrEMBL
    A0A1C7CYV8, A0A1C7CYY7
    Related
    ENSP00000330190.11, ENST00000333640.12
  2. NM_001351088.2NP_001338017.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 12, encodes isoform 3.
    Source sequence(s)
    AC139768
  3. NM_001368008.1NP_001354937.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 4, encodes isoform 3.
    Source sequence(s)
    AC139768

RNA

  1. NR_026893.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139768
    Related
    ENST00000636728.1
  2. NR_147046.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  3. NR_147047.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  4. NR_147048.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  5. NR_147049.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  6. NR_147050.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  7. NR_147051.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  8. NR_147052.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  9. NR_160429.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768
  10. NR_160430.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139768

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    51186936..51218062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429037.1XP_047284993.1  POU domain, class 6, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A1C7CYY7
  2. XM_047429034.1XP_047284990.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYV8, A0A1C7CYY7
  3. XM_047429040.1XP_047284996.1  POU domain, class 6, transcription factor 1 isoform X6

  4. XM_047429041.1XP_047284997.1  POU domain, class 6, transcription factor 1 isoform X7

  5. XM_047429039.1XP_047284995.1  POU domain, class 6, transcription factor 1 isoform X5

  6. XM_047429038.1XP_047284994.1  POU domain, class 6, transcription factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A1C7CYY7
  7. XM_047429036.1XP_047284992.1  POU domain, class 6, transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A1C7CYY7
  8. XM_047429033.1XP_047284989.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYV8, A0A1C7CYY7
  9. XM_017019514.1XP_016875003.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYV8, A0A1C7CYY7
  10. XM_047429035.1XP_047284991.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYV8, A0A1C7CYY7
  11. XM_047429043.1XP_047284999.1  POU domain, class 6, transcription factor 1 isoform X9

    UniProtKB/Swiss-Prot
    Q14863, Q15944, Q6DK47, Q7Z7P6
    UniProtKB/TrEMBL
    B3KT91
  12. XM_047429042.1XP_047284998.1  POU domain, class 6, transcription factor 1 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    51149818..51180972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372356.1XP_054228331.1  POU domain, class 6, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A1C7CYY7
  2. XM_054372353.1XP_054228328.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYY7
  3. XM_054372360.1XP_054228335.1  POU domain, class 6, transcription factor 1 isoform X7

  4. XM_054372359.1XP_054228334.1  POU domain, class 6, transcription factor 1 isoform X6

  5. XM_054372358.1XP_054228333.1  POU domain, class 6, transcription factor 1 isoform X5

  6. XM_054372355.1XP_054228330.1  POU domain, class 6, transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A1C7CYY7
  7. XM_054372357.1XP_054228332.1  POU domain, class 6, transcription factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A1C7CYY7
  8. XM_054372352.1XP_054228327.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYY7
  9. XM_054372351.1XP_054228326.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYY7
  10. XM_054372354.1XP_054228329.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYY7
  11. XM_054372350.1XP_054228325.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYY7
  12. XM_054372362.1XP_054228337.1  POU domain, class 6, transcription factor 1 isoform X9

    UniProtKB/Swiss-Prot
    Q14863, Q15944, Q6DK47, Q7Z7P6
    UniProtKB/TrEMBL
    B3KT91
  13. XM_054372361.1XP_054228336.1  POU domain, class 6, transcription factor 1 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002702.3: Suppressed sequence

    Description
    NM_002702.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.