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Pou6f1 POU domain, class 6, transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 19009, updated on 18-Apr-2024

Summary

Official Symbol
Pou6f1provided by MGI
Official Full Name
POU domain, class 6, transcription factor 1provided by MGI
Primary source
MGI:MGI:102935
See related
Ensembl:ENSMUSG00000009739 AllianceGenome:MGI:102935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emb; cns-1; 2310038G18Rik
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; nervous system; sensory organ; and skeletal musculature. Orthologous to human POU6F1 (POU class 6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 22.0), cortex adult (RPKM 16.2) and 23 other tissues See more
Orthologs
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Genomic context

Location:
15 F1; 15 56.35 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100473199..100497949, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100575318..100600061, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene STARR-seq mESC enhancer starr_39756 Neighboring gene transcription factor CP2 Neighboring gene STARR-positive B cell enhancer ABC_E7419 Neighboring gene STARR-seq mESC enhancer starr_39757 Neighboring gene STARR-positive B cell enhancer ABC_E4150 Neighboring gene RIKEN cDNA C330013E15 gene Neighboring gene STARR-positive B cell enhancer ABC_E610 Neighboring gene DAZ associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
POU domain, class 6, transcription factor 1
Names
octamer-binding transcription factor EMB
transcription regulatory protein MCP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304965.2NP_001291894.1  POU domain, class 6, transcription factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001291894.1

    Status: VALIDATED

    Source sequence(s)
    AC123724
    Consensus CDS
    CCDS79411.1
    UniProtKB/TrEMBL
    Q5U4D4, Q6X2S0
    Related
    ENSMUSP00000073504.7, ENSMUST00000073837.13
    Conserved Domains (2) summary
    pfam00046
    Location:512565
    Homeobox; Homeobox domain
    cl22952
    Location:414488
    Pou; Pou domain - N-terminal to homeobox domain
  2. NM_001404294.1NP_001391223.1  POU domain, class 6, transcription factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123724
  3. NM_001404295.1NP_001391224.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123724
    UniProtKB/Swiss-Prot
    Q07916, Q91XK3
  4. NM_001404296.1NP_001391225.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123724
    UniProtKB/Swiss-Prot
    Q07916, Q91XK3
  5. NM_001404297.1NP_001391226.1  POU domain, class 6, transcription factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123724
    UniProtKB/Swiss-Prot
    Q07916, Q91XK3
    Related
    ENSMUSP00000145707.2, ENSMUST00000176271.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100473199..100497949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248418.2XP_030104278.1  POU domain, class 6, transcription factor 1 isoform X5

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:98390
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:511565
    Homeobox; Homeobox domain
    cl22952
    Location:413487
    Pou; Pou domain - N-terminal to homeobox domain
  2. XM_006520614.5XP_006520677.1  POU domain, class 6, transcription factor 1 isoform X8

    Conserved Domains (3) summary
    PRK12323
    Location:46263
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam00046
    Location:337391
    Homeobox; Homeobox domain
    cl22952
    Location:287313
    Pou; Pou domain - N-terminal to homeobox domain
  3. XM_017316508.3XP_017171997.1  POU domain, class 6, transcription factor 1 isoform X6

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:58378
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:478532
    Homeobox; Homeobox domain
    cl22952
    Location:380454
    Pou; Pou domain - N-terminal to homeobox domain
  4. XM_017316509.2XP_017171998.1  POU domain, class 6, transcription factor 1 isoform X7

    Conserved Domains (1) summary
    PHA03247
    Location:48452
    PHA03247; large tegument protein UL36; Provisional
  5. XM_030248417.2XP_030104277.1  POU domain, class 6, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:31406
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:527581
    Homeobox; Homeobox domain
    cl22952
    Location:429503
    Pou; Pou domain - N-terminal to homeobox domain
  6. XM_006520609.4XP_006520672.1  POU domain, class 6, transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:50424
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:545599
    Homeobox; Homeobox domain
    cl22952
    Location:447521
    Pou; Pou domain - N-terminal to homeobox domain
  7. XM_030248416.1XP_030104276.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:48425
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:546600
    Homeobox; Homeobox domain
    cl22952
    Location:448522
    Pou; Pou domain - N-terminal to homeobox domain
  8. XM_006520608.4XP_006520671.1  POU domain, class 6, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    Q6X2S0
    Conserved Domains (3) summary
    PHA03247
    Location:48425
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:546600
    Homeobox; Homeobox domain
    cl22952
    Location:448522
    Pou; Pou domain - N-terminal to homeobox domain
  9. XM_030248419.1XP_030104279.1  POU domain, class 6, transcription factor 1 isoform X9

    Conserved Domains (3) summary
    PRK14951
    Location:41158
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    pfam00046
    Location:267321
    Homeobox; Homeobox domain
    cl22952
    Location:169243
    Pou; Pou domain - N-terminal to homeobox domain
  10. XM_036159263.1XP_036015156.1  POU domain, class 6, transcription factor 1 isoform X10

    Conserved Domains (2) summary
    PHA03247
    Location:58295
    PHA03247; large tegument protein UL36; Provisional
    PRK07994
    Location:170272
    PRK07994; DNA polymerase III subunits gamma and tau; Validated

RNA

  1. XR_004938810.1 RNA Sequence

    Related
    ENSMUST00000176140.8
  2. XR_004938809.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010127.3: Suppressed sequence

    Description
    NM_010127.3: This RefSeq was removed because currently there is insufficient support for the transcript and protein.