Format

Send to:

Choose Destination

POU2F2 POU class 2 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 5452, updated on 24-Nov-2020

Summary

Official Symbol
POU2F2provided by HGNC
Official Full Name
POU class 2 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:9213
See related
Ensembl:ENSG00000028277 MIM:164176
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCT2; OTF2; Oct-2
Summary
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Broad expression in lymph node (RPKM 11.8), spleen (RPKM 7.4) and 14 other tissues See more
Orthologs

Genomic context

See POU2F2 in Genome Data Viewer
Location:
19q13.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (42086113..42197931, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42590262..42636625, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor kainate type subunit 5 Neighboring gene Sharpr-MPRA regulatory regions 411/7488 and 4104 Neighboring gene zinc finger protein 574 Neighboring gene uncharacterized LOC100505622 Neighboring gene microRNA 4323 Neighboring gene death effector domain containing 2 Neighboring gene zinc finger protein 526

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol Transcription factors Oct-1, Oct-2, PU.1, Sp1, and Sp3 are recruited to the HS7 regulatory site in the pol coding region, suggesting that Oct-1, Oct-2, PU.1, Sp1, and Sp3 indirectly interact with HIV-1 Pol PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cellular response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
humoral immune response TAS
Traceable Author Statement
more info
PubMed 
immunoglobulin production involved in immunoglobulin-mediated immune response IEA
Inferred from Electronic Annotation
more info
 
mature B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin ISA
Inferred from Sequence Alignment
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
POU domain, class 2, transcription factor 2
Names
OTF-2
homeobox protein
lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
octamer-binding protein 2
octamer-binding transcription factor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030365.1 RefSeqGene

    Range
    5028..51351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207025.3NP_001193954.1  POU domain, class 2, transcription factor 2 isoform 1

    See identical proteins and their annotated locations for NP_001193954.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC022515, BF062323, M36653, M36718
    Consensus CDS
    CCDS56095.1
    UniProtKB/Swiss-Prot
    P09086
    Related
    ENSP00000431603.3, ENST00000526816.6
    Conserved Domains (2) summary
    smart00352
    Location:195269
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:300353
    Homeobox; Homeobox domain
  2. NM_001207026.2NP_001193955.1  POU domain, class 2, transcription factor 2 isoform 3

    See identical proteins and their annotated locations for NP_001193955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AC022515, M36653
    Consensus CDS
    CCDS56094.1
    UniProtKB/Swiss-Prot
    P09086
    Related
    ENSP00000436988.1, ENST00000529952.5
    Conserved Domains (2) summary
    smart00352
    Location:195269
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:300353
    Homeobox; Homeobox domain
  3. NM_001247994.2NP_001234923.1  POU domain, class 2, transcription factor 2 isoform 4

    See identical proteins and their annotated locations for NP_001234923.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses alternate splice junctions at the 5' ends of two exons compared to variant 1, the 5'-most being in-frame and the 3'-most causing a frameshift. The resulting isoform (4) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC022515, BC006101, BF062323
    Consensus CDS
    CCDS58665.1
    UniProtKB/Swiss-Prot
    P09086
    Related
    ENSP00000437224.1, ENST00000529067.5
    Conserved Domains (2) summary
    smart00352
    Location:179253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284337
    Homeobox; Homeobox domain
  4. NM_002698.5NP_002689.1  POU domain, class 2, transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_002689.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC022515, BC006101, BF062323, M36718
    Consensus CDS
    CCDS33035.1
    UniProtKB/Swiss-Prot
    P09086
    Related
    ENSP00000373992.3, ENST00000389341.9
    Conserved Domains (2) summary
    smart00352
    Location:179253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284337
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    42086113..42197931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026888.2XP_016882377.1  POU domain, class 2, transcription factor 2 isoform X3

  2. XM_017026886.2XP_016882375.1  POU domain, class 2, transcription factor 2 isoform X3

  3. XM_024451545.1XP_024307313.1  POU domain, class 2, transcription factor 2 isoform X6

    Conserved Domains (2) summary
    smart00352
    Location:288362
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:393446
    Homeobox; Homeobox domain
  4. XM_017026887.2XP_016882376.1  POU domain, class 2, transcription factor 2 isoform X3

  5. XM_024451546.1XP_024307314.1  POU domain, class 2, transcription factor 2 isoform X7

    Conserved Domains (3) summary
    smart00352
    Location:282356
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:387440
    Homeobox; Homeobox domain
    cl28087
    Location:175303
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  6. XM_024451547.1XP_024307315.1  POU domain, class 2, transcription factor 2 isoform X8

    Conserved Domains (2) summary
    smart00352
    Location:266340
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:371424
    Homeobox; Homeobox domain
  7. XM_017026892.2XP_016882381.1  POU domain, class 2, transcription factor 2 isoform X5

  8. XM_017026891.2XP_016882380.1  POU domain, class 2, transcription factor 2 isoform X4

  9. XM_017026896.2XP_016882385.1  POU domain, class 2, transcription factor 2 isoform X13

  10. XM_017026884.2XP_016882373.1  POU domain, class 2, transcription factor 2 isoform X1

  11. XM_005259010.4XP_005259067.1  POU domain, class 2, transcription factor 2 isoform X14

    See identical proteins and their annotated locations for XP_005259067.1

    UniProtKB/TrEMBL
    B5ME60
    Related
    ENSP00000339369.5, ENST00000342301.8
    Conserved Domains (2) summary
    smart00352
    Location:179253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284337
    Homeobox; Homeobox domain
  12. XM_017026894.2XP_016882383.1  POU domain, class 2, transcription factor 2 isoform X11

  13. XM_011527042.3XP_011525344.1  POU domain, class 2, transcription factor 2 isoform X17

    UniProtKB/TrEMBL
    H0YLL6
    Related
    ENSP00000453255.1, ENST00000560398.5
    Conserved Domains (2) summary
    smart00352
    Location:201275
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:306359
    Homeobox; Homeobox domain
  14. XM_017026893.2XP_016882382.1  POU domain, class 2, transcription factor 2 isoform X10

  15. XM_011527041.3XP_011525343.1  POU domain, class 2, transcription factor 2 isoform X16

    Conserved Domains (2) summary
    smart00352
    Location:217291
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:322375
    Homeobox; Homeobox domain
  16. XM_011527040.3XP_011525342.1  POU domain, class 2, transcription factor 2 isoform X9

    Conserved Domains (2) summary
    smart00352
    Location:217291
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:322375
    Homeobox; Homeobox domain
  17. XM_011527043.3XP_011525345.2  POU domain, class 2, transcription factor 2 isoform X15

  18. XM_017026890.2XP_016882379.1  POU domain, class 2, transcription factor 2 isoform X3

  19. XM_017026885.2XP_016882374.1  POU domain, class 2, transcription factor 2 isoform X2

  20. XM_017026895.2XP_016882384.1  POU domain, class 2, transcription factor 2 isoform X12

  21. XM_017026889.2XP_016882378.1  POU domain, class 2, transcription factor 2 isoform X3

RNA

  1. XR_001753710.2 RNA Sequence

  2. XR_001753709.2 RNA Sequence

Support Center