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Pou2f2 POU domain, class 2, transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 18987, updated on 6-Jun-2024

Summary

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Official Symbol
Pou2f2provided by MGI
Official Full Name
POU domain, class 2, transcription factor 2provided by MGI
Primary source
MGI:MGI:101897
See related
Ensembl:ENSMUSG00000008496 AllianceGenome:MGI:101897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Otf2; Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in cellular response to virus; positive regulation of interleukin-6 production; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within cell maturation; mature B cell differentiation; and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; nervous system; sensory organ; and thymus. Orthologous to human POU2F2 (POU class 2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 14.3), whole brain E14.5 (RPKM 4.2) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Pou2f2 in Genome Data Viewer
Location:
7 A3; 7 13.73 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24790111..24879292, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25087350..25180797, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ATPase, Na+/K+ transporting, alpha 3 polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25785259-25785485 Neighboring gene microRNA 7047 Neighboring gene glutamate receptor, ionotropic, kainate 5 (gamma 2) Neighboring gene STARR-seq mESC enhancer starr_18288 Neighboring gene zinc finger protein 574 Neighboring gene STARR-positive B cell enhancer ABC_E3704 Neighboring gene microRNA 6537 Neighboring gene STARR-seq mESC enhancer starr_18291 Neighboring gene STARR-positive B cell enhancer ABC_E2225 Neighboring gene STARR-positive B cell enhancer ABC_E6522 Neighboring gene STARR-positive B cell enhancer ABC_E3705 Neighboring gene RIKEN cDNA D930028M14 gene Neighboring gene STARR-seq mESC enhancer starr_18292 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25990365-25990647 Neighboring gene STARR-seq mESC enhancer starr_18294 Neighboring gene STARR-positive B cell enhancer ABC_E868 Neighboring gene STARR-positive B cell enhancer ABC_E1724 Neighboring gene RIKEN cDNA 9130221H12 gene Neighboring gene death effector domain-containing DNA binding protein 2 Neighboring gene microRNA 7048 Neighboring gene zinc finger protein 526 Neighboring gene glycogen synthase kinase 3 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of the Oct-2 transcription factor in mouse mammary gland and cloning and characterization of a novel Oct-2 isoform. Dong B, et al. Cell Tissue Res, 2007 Jun. PMID 17285328
  2. oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function. Humbert PO, et al. J Immunol, 1997 Dec 1. PMID 9548466
  3. Transcription factor Oct-2 is expressed in primary murine macrophages. Dunn TL, et al. Blood, 1996 Nov 15. PMID 8916976
  4. Nerve growth factor-regulated properties of sensory neurones in Oct-2 null mutant mice. Ninkina NN, et al. Brain Res Mol Brain Res, 1995 Nov. PMID 8750882
  5. Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation. Feldhaus AL, et al. EMBO J, 1993 Jul. PMID 8334992, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POU Domain Class 2 Transcription Factor 2 Inhibits Ferroptosis in Cerebral Ischemia Reperfusion Injury by Activating Sestrin2.
    Title: POU Domain Class 2 Transcription Factor 2 Inhibits Ferroptosis in Cerebral Ischemia Reperfusion Injury by Activating Sestrin2.
  2. The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus.
    Title: The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus.
  3. OBF1 and Oct factors control the germinal center transcriptional program.
    Title: OBF1 and Oct factors control the germinal center transcriptional program.
  4. Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
    Title: Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
  5. Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
    Title: Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
  6. findings, combined with the predominantly B-cell-restricted expression of OCT2 and the absence of a systemic phenotype in our knockout mice, suggest that an OCT2-targeted therapeutic strategy would be efficacious in both major subtypes of DLBCL while avoiding systemic toxicity
    Title: Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2.
  7. overexpression of DDX60 did not potentiate IFN induction
    Title: NF-κB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells.
  8. Oct2 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis.
    Title: Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.
  9. The circadian expression of OCT2 was closely related to the dose-time dependency of cisplatin incorporation into renal DNA.
    Title: Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice.
  10. These findings indicate that Oct-2 induction of MiR-210 provides a novel inhibitory mechanism for the control of B cells and autoantibody production.
    Title: MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC124154, MGC124155, MGC124156

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables spermidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immunoglobulin production involved in immunoglobulin-mediated immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mature B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
POU domain, class 2, transcription factor 2
Names
lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
octamer-binding protein 2
octamer-binding transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163554.2 → NP_001157026.1  POU domain, class 2, transcription factor 2 isoform 4

    See identical proteins and their annotated locations for NP_001157026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an additional exon in the 3' coding region, as compared to variant 1. The resulting isoform (4) has a longer and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC120393
    Consensus CDS
    CCDS52144.1
    UniProtKB/Swiss-Prot
    Q00196
    Related
    ENSMUSP00000104056.4, ENSMUST00000108418.11
    Conserved Domains (2) summary
    smart00352
    Location:179 → 253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284 → 337
    Homeobox; Homeobox domain

  2. NM_001163555.2 → NP_001157027.1  POU domain, class 2, transcription factor 2 isoform 3

    See identical proteins and their annotated locations for NP_001157027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional segment in the coding region, as compared to variant 1. The resulting isoform (3) is longer and has the same N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AC120393
    Consensus CDS
    CCDS52145.1
    UniProtKB/TrEMBL
    H3BKB7
    Related
    ENSMUSP00000104055.3, ENSMUST00000108417.10
    Conserved Domains (2) summary
    smart00352
    Location:201 → 275
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:306 → 360
    Homeobox; Homeobox domain

  3. NM_001163556.2 → NP_001157028.1  POU domain, class 2, transcription factor 2 isoform 1

    See identical proteins and their annotated locations for NP_001157028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC120393
    Consensus CDS
    CCDS52143.1
    UniProtKB/Swiss-Prot
    Q00196, Q00197, Q00198, Q00199, Q00200, Q00201, Q05882, Q3KR47, Q3U127, Q5XML1, Q5XML2, Q61995, Q61996, Q64245
    UniProtKB/TrEMBL
    H3BKB7
    Related
    ENSMUSP00000135075.2, ENSMUST00000175774.9
    Conserved Domains (2) summary
    smart00352
    Location:179 → 253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284 → 338
    Homeobox; Homeobox domain

  4. NM_001417132.1 → NP_001404061.1  POU domain, class 2, transcription factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC120393

  5. NM_001417133.1 → NP_001404062.1  POU domain, class 2, transcription factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC120393

  6. NM_001417134.1 → NP_001404063.1  POU domain, class 2, transcription factor 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC120393

  7. NM_001417135.1 → NP_001404064.1  POU domain, class 2, transcription factor 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC120393

  8. NM_001417136.1 → NP_001404065.1  POU domain, class 2, transcription factor 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC120393

  9. NM_001417137.1 → NP_001404066.1  POU domain, class 2, transcription factor 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC120393

  10. NM_001417138.1 → NP_001404067.1  POU domain, class 2, transcription factor 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC120393

  11. NM_001417139.1 → NP_001404068.1  POU domain, class 2, transcription factor 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC120393

  12. NM_001417140.1 → NP_001404069.1  POU domain, class 2, transcription factor 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC120393
    UniProtKB/TrEMBL
    H3BKB7
    Related
    ENSMUSP00000104054.3, ENSMUST00000108416.10

  13. NM_001417141.1 → NP_001404070.1  POU domain, class 2, transcription factor 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC120393

  14. NM_011138.3 → NP_035268.2  POU domain, class 2, transcription factor 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the coding region, as compared to variant 1. The resulting isoform (2) is longer and has the same N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AC120393
    Consensus CDS
    CCDS39834.1
    UniProtKB/TrEMBL
    H3BKB7
    Related
    ENSMUSP00000104053.3, ENSMUST00000108415.10
    Conserved Domains (3) summary
    smart00352
    Location:195 → 269
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:300 → 354
    Homeobox; Homeobox domain
    pfam09770
    Location:116 → 193
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24790111..24879292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00196.4 GenPept UniProtKB/Swiss-Prot:Q00196

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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