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Pou2f2 POU domain, class 2, transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 18987, updated on 21-Apr-2024

Summary

Official Symbol
Pou2f2provided by MGI
Official Full Name
POU domain, class 2, transcription factor 2provided by MGI
Primary source
MGI:MGI:101897
See related
Ensembl:ENSMUSG00000008496 AllianceGenome:MGI:101897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Otf2; Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in cellular response to virus; positive regulation of interleukin-6 production; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within cell maturation; mature B cell differentiation; and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; nervous system; sensory organ; and thymus. Orthologous to human POU2F2 (POU class 2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 14.3), whole brain E14.5 (RPKM 4.2) and 11 other tissues See more
Orthologs
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Genomic context

Location:
7 A3; 7 13.73 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24790111..24879292, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25087350..25180797, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ATPase, Na+/K+ transporting, alpha 3 polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25785259-25785485 Neighboring gene microRNA 7047 Neighboring gene glutamate receptor, ionotropic, kainate 5 (gamma 2) Neighboring gene STARR-seq mESC enhancer starr_18288 Neighboring gene zinc finger protein 574 Neighboring gene STARR-positive B cell enhancer ABC_E3704 Neighboring gene microRNA 6537 Neighboring gene STARR-seq mESC enhancer starr_18291 Neighboring gene STARR-positive B cell enhancer ABC_E2225 Neighboring gene STARR-positive B cell enhancer ABC_E6522 Neighboring gene STARR-positive B cell enhancer ABC_E3705 Neighboring gene RIKEN cDNA D930028M14 gene Neighboring gene STARR-seq mESC enhancer starr_18292 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25990365-25990647 Neighboring gene STARR-seq mESC enhancer starr_18294 Neighboring gene STARR-positive B cell enhancer ABC_E868 Neighboring gene STARR-positive B cell enhancer ABC_E1724 Neighboring gene RIKEN cDNA 9130221H12 gene Neighboring gene death effector domain-containing DNA binding protein 2 Neighboring gene microRNA 7048 Neighboring gene zinc finger protein 526 Neighboring gene glycogen synthase kinase 3 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Clone Names

  • MGC124154, MGC124155, MGC124156

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
POU domain, class 2, transcription factor 2
Names
lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
octamer-binding protein 2
octamer-binding transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163554.2NP_001157026.1  POU domain, class 2, transcription factor 2 isoform 4

    See identical proteins and their annotated locations for NP_001157026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an additional exon in the 3' coding region, as compared to variant 1. The resulting isoform (4) has a longer and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC120393
    Consensus CDS
    CCDS52144.1
    UniProtKB/Swiss-Prot
    Q00196
    Related
    ENSMUSP00000104056.4, ENSMUST00000108418.11
    Conserved Domains (2) summary
    smart00352
    Location:179253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284337
    Homeobox; Homeobox domain
  2. NM_001163555.2NP_001157027.1  POU domain, class 2, transcription factor 2 isoform 3

    See identical proteins and their annotated locations for NP_001157027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional segment in the coding region, as compared to variant 1. The resulting isoform (3) is longer and has the same N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AC120393
    Consensus CDS
    CCDS52145.1
    UniProtKB/TrEMBL
    H3BKB7
    Related
    ENSMUSP00000104055.3, ENSMUST00000108417.10
    Conserved Domains (2) summary
    smart00352
    Location:201275
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:306360
    Homeobox; Homeobox domain
  3. NM_001163556.2NP_001157028.1  POU domain, class 2, transcription factor 2 isoform 1

    See identical proteins and their annotated locations for NP_001157028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC120393
    Consensus CDS
    CCDS52143.1
    UniProtKB/Swiss-Prot
    Q00196, Q00197, Q00198, Q00199, Q00200, Q00201, Q05882, Q3KR47, Q3U127, Q5XML1, Q5XML2, Q61995, Q61996, Q64245
    UniProtKB/TrEMBL
    H3BKB7
    Related
    ENSMUSP00000135075.2, ENSMUST00000175774.9
    Conserved Domains (2) summary
    smart00352
    Location:179253
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:284338
    Homeobox; Homeobox domain
  4. NM_001417132.1NP_001404061.1  POU domain, class 2, transcription factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC120393
  5. NM_001417133.1NP_001404062.1  POU domain, class 2, transcription factor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC120393
  6. NM_001417134.1NP_001404063.1  POU domain, class 2, transcription factor 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC120393
  7. NM_001417135.1NP_001404064.1  POU domain, class 2, transcription factor 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC120393
  8. NM_001417136.1NP_001404065.1  POU domain, class 2, transcription factor 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC120393
  9. NM_001417137.1NP_001404066.1  POU domain, class 2, transcription factor 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC120393
  10. NM_001417138.1NP_001404067.1  POU domain, class 2, transcription factor 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC120393
  11. NM_001417139.1NP_001404068.1  POU domain, class 2, transcription factor 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC120393
  12. NM_001417140.1NP_001404069.1  POU domain, class 2, transcription factor 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC120393
    Related
    ENSMUSP00000104054.3, ENSMUST00000108416.10
  13. NM_001417141.1NP_001404070.1  POU domain, class 2, transcription factor 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC120393
  14. NM_011138.3NP_035268.2  POU domain, class 2, transcription factor 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the coding region, as compared to variant 1. The resulting isoform (2) is longer and has the same N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AC120393
    Consensus CDS
    CCDS39834.1
    UniProtKB/TrEMBL
    H3BKB7
    Related
    ENSMUSP00000104053.3, ENSMUST00000108415.10
    Conserved Domains (3) summary
    smart00352
    Location:195269
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:300354
    Homeobox; Homeobox domain
    pfam09770
    Location:116193
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24790111..24879292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)