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DHX29 DExH-box helicase 29 [ Homo sapiens (human) ]

Gene ID: 54505, updated on 5-Jul-2020

Summary

Official Symbol
DHX29provided by HGNC
Official Full Name
DExH-box helicase 29provided by HGNC
Primary source
HGNC:HGNC:15815
See related
Ensembl:ENSG00000067248 MIM:612720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX29
Summary
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in thyroid (RPKM 12.7), prostate (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See DHX29 in Genome Data Viewer
Location:
5q11.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (55256055..55307694, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54552073..54603521, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene cyclin O Neighboring gene uncharacterized LOC105378973 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene protein serine kinase H1 pseudogene Neighboring gene uncharacterized LOC107986415

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21492

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
nucleoside-triphosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal small subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
translation activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
formation of translation preinitiation complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
 
ribosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic 43S preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ATP-dependent RNA helicase DHX29
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
DEAH box protein 29
DEAH-box helicase 29
nucleic acid helicase DDXx
NP_001332893.1
NP_001332894.1
NP_061903.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051592.1 RefSeqGene

    Range
    5029..56668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001345964.2NP_001332893.1  ATP-dependent RNA helicase DHX29 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC020728, AC026704, AL834496
    UniProtKB/Swiss-Prot
    Q7Z478
  2. NM_001345965.2NP_001332894.1  ATP-dependent RNA helicase DHX29 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate translation start site compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL834496, BX649135
    UniProtKB/Swiss-Prot
    Q7Z478
    Related
    ENST00000504778.5
    Conserved Domains (1) summary
    COG1643
    Location:21681
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  3. NM_019030.4NP_061903.2  ATP-dependent RNA helicase DHX29 isoform 1

    See identical proteins and their annotated locations for NP_061903.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL834496, AY036974, BX649135, DB122058
    Consensus CDS
    CCDS34158.1
    UniProtKB/Swiss-Prot
    Q7Z478
    Related
    ENSP00000251636.5, ENST00000251636.10
    Conserved Domains (5) summary
    smart00487
    Location:578764
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:10561137
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:589736
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:847985
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:11791302
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RNA

  1. NR_144323.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, resulting in a longer transcript compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020728, AC026704, AL834496
  2. NR_144324.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, resulting in a longer transcript compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020728, AC026704, AL834496
  3. NR_144325.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two alternate splice sites in internal exons, resulting in a shorter transcript compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020728, AC026704, AL834496

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    55256055..55307694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001742128.2 RNA Sequence

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